O-071 Salt-sparing Diuretic Action Of A Urea Analogue Inhibitor Of Urea Transporters Ut-a And Ut-b In Rats

Abstract

Background and aims If infants fail to initiate spontaneous breathing after birth, international guidelines recommend positive pressure ventilation (PPV). However, mask PPV remains challenging with leakage occurring commonly. Despite a variety of available facemasks, none has been systemically studied in newborn infants. We aimed to determine if using a Fisher and Paykel (FP) round facemask would reduce mask leak compared to using a Laerdal round facemask during mask PPV in preterm infants.Methods From April to September 2013, at the Royal Alexandra Hospital, newborn infants. Results Fifty-eight preterm infants (n = 29 in each group) were enrolled; mean±SD gestation 28 ± 3 weeks; birth weight 1210 ± 448 g, 30(52%) male, 39(67%) born by caesarean section. Apgar scores at 1 and 5 min were 5 ± 3 and 7 ± 2, respectively. Infants randomised to the FP facemask and Laerdal facemask had similar mask leak (37 ± 17% vs. 33 ± 12%, respectively, p = 0.30) and tidal volume (7.3 ± 3.0 mL/kg vs. 6.9 ± 2.7 mL/ kg, p = 0.73) during PPV. There were no significant differences in ventilation rate, inflation time or airway pressures between groups. Conclusions The use of either facemask during PPV in the delivery room yields similar mask leak. Background and aims Endotracheal intubation is a mandatory skill for neonatal trainees. However, inexperienced trainees have success rates <50%. We compared intubations supervised by an instructor watching a videolaryngoscope screen with the traditional method where the instructor does not have this view. Methods RCT (ANZCTR# 12613000159752) at The Royal Women's Hospital, Melbourne. Eligible intubations were those performed orally, in infants without facial or airway anomalies, in the delivery room or in NICU, by trainees with <6 months experience. Intubations were randomised to videolaryngoscope screen visible to the instructor (intervention) or covered (control). Primary outcome was first attempt intubation success rate confirmed by colorimetric detection of expired CO 2 . A sample size of 206 provided 80% power to detect a 20% difference in success rates (50% vs. 70%). Background Continuous Renal Replacement Therapies (CRRT) are the treatment of choice for critically ill children with Acute Renal Injury. Hypotension after starting CRRT is frequent but there are no studies that have analysed their incidence and importance. Patients and methods A prospective, observational study was performed including critically ill children treated with CRRT between October 2009 and December 2013. Hemodynamic data and connection characteristics were collected before, during and 60 min after CRRT circuit connection. Hypotension with the connection was defined as a decrease in mean arterial pressure >20% from baseline and/or intravenous fluid expansion and/or if increase in vasopressors was required. Results 161 connections in 36 children (median age 18.8 months) were analysed. 28 patients (77.8%) were in the postoperative period of cardiac surgery, 94% on mechanical ventilation and 86.1% with vasopressors. T...

Expression and Transport Characteristics of Urea Channel Protein B in Rat Bladder Cance

“…The antiserum of UT-A3 was detected at the carboxyl end of UT-A3, and it was found that UT-A3 existed in the cell armament of IMCD. It can be used as a cell's UTS storage tank, and has the ability to enter the plasma membrane, leading to the rapid improvement of urinary system permeability [9].…”