O-benzyl-N-(2-indolyl) urethans

Design, synthesis and cytotoxic activity of novel 1-aroyl-4-(2-chloroethyl)semicarbazides

“…The key hydrazide intermediates 1 -7 were prepared by addition of the corresponding p-substituted ethyl benzoate ester to excess hydrazine hydrate in ethanol, followed by refluxing the reaction mixture for 2 h [15]. The acid hydrazides were then reacted with 2-chloroethylisocyanate in ethanol for 12 h at room temperature in order to obtain the target compounds 8 -14.…”

“…The hydrazide intermediates (15 -19) were prepared as described in [15]. These hydrazides were stirred with 2-chloroethylisocyanate in dioxane at room temperature for 12 h to afford the target compounds (20 -24).…”

“…Starting materials were purchased from Lancaster Synthesis Corporation (United Kingdom). Hydrazide intermediates (1 -7, 15 -19) were synthesized using a method described in [15].…”