O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells

Snima, K. S.; Jayakumar, R.; Unnikrishnan, Ambika Gopalakrishnan; Nair, Shantikumar V.; Lakshmanan, Vinoth-Kumar

doi:10.1016/j.carbpol.2012.04.050

Cited by 106 publications

(42 citation statements)

References 10 publications

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“…Nanoparticles were taken up nonspecifically by normal and pancreatic cancer cells. Degree of hemolysis caused by drug loaded and blank nanoparticles was less than 5% (Snima et al, 2012). Snima et al (2014) also evaluated the O-carboxymethyl chitosan nanoparticles for pancreatic cancer therapy by means of in vitro (migration assay, clonogenic assay, cell cycle analysis and qRT-PCR analysis) and in vivo (biodistribution studies) studies.…”

Section: Metformin-loaded Microparticles and Nanoparticlesmentioning

confidence: 99%

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Çetin

Şahin

2015

Drug Delivery

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Context: Metformin hydrochloride is a biguanide derivative widely used for the treatment of type 2 diabetes, prescribed nearly to 120 million people worldwide. Metformin has a relatively low oral bioavailability (about 50-60%). Although the major effect of metformin is to decrease hepatic glucose output as an antihyperglycemic agent, its inhibitory effects on the proliferation of some cancer cells (e.g. prostate, breast, glioma cells) have been demonstrated in the cell culture studies. Development of novel formulation (e.g. microparticles, nanoparticles) strategies for metformin might be useful to improve its bioavailability, to reduce the dosing frequency, to decrease gastrointestinal side effects and toxicity and to be helpful for effective use of metformin in cancer treatment. Objective: The main aim of this review is to summarize metformin HCl-loaded micro-and nanoparticulate drug delivery systems. Method: The literature was rewieved with regard to the physicochemical, pharmacological properties of metformin, and also its mechanism of action in type 2 diabetes and cancer. In addition, micro-and nanoparticulate drug delivery systems developed for metformin were gathered from the literature and the results were discussed. Conclusion: Metformin is an oral antihyperglycemic agent and also has potential antitumorigenic effects. The repeated applications of high doses of metformin (as immediate release formulations) are needed for an effective treatment due to its low oral bioavailability and short biological half-life. Drug delivery systems are very useful systems to overcome the difficulties associated with conventional dosage forms of metformin and also for its effective use in cancer treatment.

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Section: Metformin-loaded Microparticles and Nanoparticlesmentioning

confidence: 99%

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Çetin

Şahin

2015

Drug Delivery

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“…To fulfill this purpose, carboxymethyl chitosan (CM-chitosan), water-soluble derivatives of chitosan with carboxymethyl group was selected due to its controllable self-aggregation and bioadhesive promoting property (Mourya, Inamdar, & Tiwari, 2010;Thanou, Verhoef, & Junginger, 2001). Several studies have utilized CMchitosan to produce nanoparticles through ionic gelation induced by calcium ions (Luo et al, 2013;Shi, Du, Yang, Zhang, & Sun, 2006;Snima, Jayakumar, Unnikrishnan, Nair, & Lakshmanan, 2012). Here it is noted that CM-chitosan with 87e90% DS (degree of substitution) has polyampholytic (zwitter ionic) character, which allows the formation of clear gels or solutions at neutral and alkaline pH values but aggregates under acidic conditions (Thanou et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Assembly of kafirin/carboxymethyl chitosan nanoparticles to enhance the cellular uptake of curcumin

2015

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“…Туморогенность -только РСК способны иницииро-вать малигнизацию, поэтому их называют «клетки-инициации опухолевого роста», с тем чтобы подчер-кнуть их онкогенный потенциал. Следует отметить еще одну важную черту -РСК яв-ляются гораздо более химио-и радиорезистентными, чем дифференцированные клетки, которые образуют опу-холевую массу, и, таким образом, они ответственны за ле-карственную устойчивость и рецидив опухоли [19,20].…”

Section: влияние на раковые стволовые клеткиunclassified

“…Так, авторы предлагают коинкапсулировать в липосомах метформин и эпирубицин [22]. В последние два года по-явилось множество публикаций, в которых обсуждаются способы доставки метформина [17,19].…”

Section: влияние на раковые стволовые клеткиunclassified

Metformin as target metabolic drug in oncology

Шатова¹,

Каплун²,

Зинкович³

2017

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O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells

Cited by 106 publications

References 10 publications

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

Assembly of kafirin/carboxymethyl chitosan nanoparticles to enhance the cellular uptake of curcumin

Metformin as target metabolic drug in oncology

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