O. K. or K. O?

Klein, Jan

doi:10.1007/bf01246681

Cited by 11 publications

(12 citation statements)

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“…[11][12][13][14][15][16][17][18] Such potentials have a number of simple properties. IPL potentials have, however, been considered unrealistic because their predicted equation of state is quite unrealistic and because they have no stable low-pressure liquid phase and no van der Waals loop, problems that derive from the fact that IPL potentials are purely repulsive.…”

Section: A Ipl Potentialsmentioning

confidence: 99%

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Pressure-energy correlations in liquids. III. Statistical mechanics and thermodynamics of liquids with hidden scale invariance

Schrøder

Bailey

Pedersen

et al. 2009

The Journal of Chemical Physics

131

150

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In this third paper of the series, which started with Bailey et al. ͓J. Chem. Phys. 129, 184507 ͑2008͒; ibid. 129, 184508 ͑2008͔͒, we continue the development of the theoretical understanding of strongly correlating liquids-those whose instantaneous potential energy and virial are more than 90% correlated in their thermal equilibrium fluctuations at constant volume. The existence of such liquids was detailed in previous work, which identified them, based on computer simulations, as a large class of liquids, including van der Waals liquids but not, e.g., hydrogen-bonded liquids. We here discuss the following: ͑1͒ the scaling properties of inverse power-law and extended inverse power-law potentials ͑the latter includes a linear term that "hides" the approximate scale invariance͒; ͑2͒ results from computer simulations of molecular models concerning out-of-equilibrium conditions; ͑3͒ ensemble dependence of the virial/potential-energy correlation coefficient; ͑4͒ connection to the Grüneisen parameter; and ͑5͒ interpretation of strong correlations in terms of the energy-bond formalism.

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Section: A Ipl Potentialsmentioning

confidence: 99%

“…11,12 It follows from Eq. ͑7͒ that the excess free energy of an IPL liquid is given as follows in terms of a function of density to the power n / 3 over temperature T , ͑ n/3 / T͒ ͑Klein's theorem 11,12 ͒:…”

Section: A Ipl Potentialsmentioning

confidence: 99%

Pressure-energy correlations in liquids. III. Statistical mechanics and thermodynamics of liquids with hidden scale invariance

Schrøder

Bailey

Pedersen

et al. 2009

The Journal of Chemical Physics

131

150

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“…The degradation of sphingolipids by lysosomal lipid hydrolases is facilitated by sphingolipid activator proteins, with the enzymatic deglycosylation of monohexosyl and small oligosaccharyl ceramides and the desulfation of sulfogalactosyl ceramide being dependent on activator proteins (for review, see [1]). In addition, the enzymatic hydrolysis of ceramide to sphingosine and fatty acid is also mediated by an activator protein [2,3].…”

Section: Introductionmentioning

confidence: 99%

Saposins (sap) A and C activate the degradation of galactosylsphingosine

2001

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As previously shown for [ 3 H-galactosyl]ceramide, the breakdown of [ 3 H-galactosyl]sphingosine was reduced in prosaposin-deficient skin fibroblast homogenates. Galactosylsphingosine hydrolysis was also deficient in cell homogenates from Krabbe's disease (L L-galactocerebrosidase-deficient) patients, but not acid L L-galactosidase-deficient patients. Moreover, hydrolysis of galactosylsphingosine in the prosaposin-deficient cell homogenates could be partially restored by adding pure saposin A or C, thereby identifying these saposins as essential facilitators of galactosylsphingosine hydrolysis. By contrast, saposins B and D had little effect on galactosylsphingosine hydrolysis in the prosaposin-deficient cells. The reduced galactosylsphingosine turnover in prosaposin-deficiency suggests that there could be a pathogenetic cerebral accumulation of galactosylsphingosine in this disorder. ß 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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“…Of the four saposins, the crucial role of sap B in the solubilization of some sphingolipid substrates (e.g. sulfatide and globotriaosylceramide [17]) has been clearly established (for review, see [18]), and recently the role of sap D in the activation of ceramide hydrolysis by acid ceramidase has been recognized [3,16,19].…”

Section: Introductionmentioning

confidence: 99%

Saposins (sap) A and C activate the degradation of galactosylceramide in living cells

et al. 1997

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In loading tests using galactosylceramide which had been labelled with tritium in the ceramide moiety, living skin fibroblast lines derived from the original prosaposin-deficient patients had a markedly reduced capacity to degrade galactosylceramide. The hydrolysis of galactosylceramide could be partially restored in these cells, up to about half the normal rate, by adding pure saposin A, pure saposin C, or a mixture of these saposins to the culture medium. By contrast, saposins B and D had little effect on galactosylceramide hydrolysis in the prosaposin-deficient cells. Cells from P-galactocerebrosidasedeficient (Krabbe) patients had a relatively high residual galactosylceramide degradation, which was similar to the rate observed for prosaposin-deficient cells in the presence of saposin A or C. An SV40-transformed fibroblast line from the original saposin C-deficient patient, where saposin A is not affected, showed normal degradation of galactosylceramide. The findings support the hypothesis, which was deduced originally from in vitro experiments, that saposins A and C are the in vivo activators of galactosylceramide degradation. Although the results with saposin C-deficient fibroblasts suggest that the presence of only saposin A allows galactosylceramide breakdown to proceed at a normal rate in fibroblasts, it remains to be determined whether saposins A and C can substitute for each other with respect to their effects on galactosylceramide metabolism in the whole organism. © 1997 Federation of European Biochemical Societies.

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O. K. or K. O?

Cited by 11 publications

References 0 publications

Pressure-energy correlations in liquids. III. Statistical mechanics and thermodynamics of liquids with hidden scale invariance

Pressure-energy correlations in liquids. III. Statistical mechanics and thermodynamics of liquids with hidden scale invariance

Saposins (sap) A and C activate the degradation of galactosylsphingosine

Saposins (sap) A and C activate the degradation of galactosylceramide in living cells

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