The aim of this study was to assess the significance of experiences and the knowledge involved in the process of professional development of Accounting Science professors in higher education courses in Brazil. The analyzed specific objectives, through significative experiences, were: (i) the career path of such professor, in and out of the academic environment; (ii) the main challenges, expectations and influences/motivation along the way and; (iii) the knowledge involved in their professional development process. For such, a theoretical discussion was performed based on the Integrated Model for Teachers Professional Development created by Clarke and Hollingsworth (2002), which proposes that professional development happens through mediating processes of "reflexion and application" within four analytical domains: (i) personal domain; (ii) teaching practice domain; (iii) consequence domain and, (iv) external domain, connected to the knowledge perspective of Tardif ( 2012), and the twenty-six subjects experiment on the building of that knowledge. The interviewed group presented diverse characteristics; were in different stages in their career path, had diverse academic background; and their practice ranged from public to private Higher Education Institutions. We have used the semi-structured interview with a qualitative and reflexive approach to establish the narratives based on a twenty-two-question guideline. We have carried out the analysis based on a template developed by King (2004). We have identified five categories, which guided all the analysis process: (1) experience prior to the teaching career; (2) entrance in university teaching: challenges, expectations and influences;(3) mobilization of experimental knowledge in the teaching practice; (4) external stimulation to the teaching practice; and (5) the results on their professional development in and out of the classroom. From the analysis results, we have concluded that the reference-professors in Accounting Sciences are the ones that improve their teaching practice through reflexion and action on their own practice, steming from positive relationship, partnership, support and orientation, agreed with students, by means of an exchange of experiences with their peers and the professional market, as well as, the search for the improvement of their daily teaching practice. They are professors with contemporary, plural and heterogenic knowledge, which are personalized and situated as stated by Tardif (2012). Besides the theoretical contributions, we understand the importance of some practical contributions that may be suggested: (1) Follow-up process in graduation mentoring with a view to the "first opportunity to get in touch with the teaching practice"; (2) the availability of interaction and socialization spaces among the teaching professionals, which is provided by the course coordinators as a means of motivation and improvement of the teaching practice and ; (3) the action of rethinking in higher education institutions about how initial and continuous te...