O Zoledronato no tratamento da osteoporose umeral em ratas: estudo prospectivo e randomizado

Palácio, Evandro Pereira; Jacob, Eduardo Martinelli; Campi, Thiago Balthazar; Müller, Sérgio Swain

doi:10.1590/s1413-78522010000200006

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…The significantly increased maximum load in the ZA groups (OZA and SZA) can probably be explained by inhibition of osteoclast activity, which diminished the osteoporotic process even in the oophorectomized group (OZA). In similar biomechanical investigations [14, 15], compressive tests conducted on bone regions with lower concentrations of trabecular bone, such as the tibial diaphysis, produced nonsignificant results. The hormonal deficit caused by a bilateral oophorectomy results in a loss of bone mass and consequent decrease in the maximum load.…”

Section: Discussionmentioning

confidence: 95%

“…For determination of biomechanical properties, the assay machine applied to the femurs an axial load under the speed of 30 mm/min, considered by other authors [14–18] as the ideal average speed for viscoelastic materials (bone). It was also taken into consideration the capacity and type of the used assay machine, which does not allow high speed or impact testing.…”

Section: Discussionmentioning

confidence: 99%

“…It was also taken into consideration the capacity and type of the used assay machine, which does not allow high speed or impact testing. Since the scope of this study was to evaluate only fractures around the hip, the femurs were distally fixated in the acrylic resin in a proportion of 2 : 3; in others studies that considered fractures of the femurs at lower sites (diaphysis and lower diaphysis fractures), femurs were fixated in a proportion of 1 : 3 [14, 15]. …”

Section: Discussionmentioning

confidence: 99%

“…Once the test was initiated, the cleaver of the testing machine descended axially on the femoral head at a constant speed of 30 mm/min [14–18] (Figure 3). The M test program interrupted the test at the specimen's breaking point and automatically provided the results.…”

Section: Methodsmentioning

confidence: 99%

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Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Palácio

Müller

Sardenberg

et al. 2012

Journal of Osteoporosis

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Aim. To investigate the biomechanical effects of zoledronic acid (ZA) on femurs of female osteoporotic rats after follow-up periods of 9 and 12 months. Methods. Eighty female Wistar rats were prospectively assessed. At 60 days of age, the animals were randomly divided into two groups: bilateral oophorectomy (O) (n = 40) and sham surgery (S) (n = 40). At 90 days of age, groups O and S were randomly subdivided into four groups, according to whether 0.1 mg/kg of ZA or distilled water (DW) was intraperitoneally administered: OZA (n = 20), ODW (n = 20), SZA (n = 20), and SDW (n = 20). The animals were sacrificed at 9 and 12 months after the administration of the substances, and then their right femurs were removed and analyzed biomechanically. Axial compression tests that focused on determining the maximum load (N), yield point (N), and stiffness coefficient (N/mm) of the proximal femur were performed in the biomechanical study. Results. ZA significantly increased the maximum load and yield point, reducing the stiffness coefficient concerning the oophorectomy status and follow-up period. Conclusion. Zoledronic acid, at a dose of 0.1 mg/kg, significantly increased the maximum loads and yield points and reduced the stiffness coefficients in the femurs of female rats with osteoporosis caused by bilateral oophorectomy.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Palácio

Müller

Sardenberg

et al. 2012

Journal of Osteoporosis

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“…The maximum load (N) upon rupture and load-deformation curve were automatically provided by the program as previously described. 26 …”

Section: Biomechanical Testingmentioning

confidence: 99%

Treatment study of distal femur for parathyroid hormone (1–34) and β-tricalcium phosphate on bone formation in critical size defects in rats

Tao

Zhou

et al. 2015

J Biomater Appl

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The objective of this study was to evaluate local bone formation following systemic administration of parathyroid hormone (1-34), a surgically implanted synthetic β-tricalcium phosphate bone biomaterial serving as a matrix to support new bone formation. Twelve weeks after bilateral ovariectomy, all rats underwent bone defect in the distal femurs, and β-tricalcium phosphate was implanted into critical sized defects. After defect operation, all animals were randomly divided into four groups and received following subcutaneous injections until death at four and eight weeks: sham rats (group ST); sham rats + parathyroid hormone, 30 µg/kg, three times a week (group SPT); OVX rats (group OT); and OVX rats + parathyroid hormone (group OPT). The distal femurs of rats were harvested for evaluation. The treatment group demonstrating the highest levels of new bone formation was the defects treated with parathyroid hormone as assessed by micro-computed tomography, biomechanical strength, and histological analysis for sham rats. Furthermore, parathyroid hormone showed a stronger effect on accelerating the degradation of β-tricalcium phosphate. Osteoporosis can limit the function of parathyroid hormone and/or β-tricalcium phosphate. The results from our study demonstrate that combination of parathyroid hormone and β-tricalcium phosphate brings better effect to bone tissue repair in non-osteoporosis and/or osteoporosis status.

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Efeitos do etil‐2‐cianoacrilato e do butil‐2‐cianoacrilato no processo de consolidação óssea em ratos. Estudo experimental controlado

Palácio

Pereira

Silvares

et al. 2018

Revista Brasileira de Ortopedia

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O Zoledronato no tratamento da osteoporose umeral em ratas: estudo prospectivo e randomizado

Cited by 7 publications

References 11 publications

Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats

Treatment study of distal femur for parathyroid hormone (1–34) and β-tricalcium phosphate on bone formation in critical size defects in rats

Efeitos do etil‐2‐cianoacrilato e do butil‐2‐cianoacrilato no processo de consolidação óssea em ratos. Estudo experimental controlado

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