O4‐05‐01: Apolipoprotein Ε4 Allele Effects on Longitudinal Cognitive Trajectories Are Sex‐ and Age‐dependent

Williams, Owen A.; An, Yang; Armstrong, Nicole; Shafer, Andrea T.; Helphrey, Jessica H; Kitner‐Triolo, Melissa; Resnick, Susan M.

doi:10.1016/j.jalz.2019.06.4764

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Aging and Apoe1

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2022

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“…A pattern of more cognitive decline, mimicking the process of AD, has been found in clinically normal APOE ε4 carriers [ 70 ]. This cognitive decline was later reported to be strengthened by aging [ 71 ]. Second, APOE ε4 is associated with accelerated augmentation of AD incidence with age.…”

Section: Aging and Apoementioning

confidence: 99%

Factors Influencing Alzheimer’s Disease Risk: Whether and How They are Related to the APOE Genotype

Zhang

et al. 2022

Neurosci. Bull.

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Alzheimer's disease (AD) is the most prevalent neurodegenerative disease featuring progressive cognitive impairment. Although the etiology of late-onset AD remains unclear, the close association of AD with apolipoprotein E (APOE), a gene that mainly regulates lipid metabolism, has been firmly established and may shed light on the exploration of AD pathogenesis and therapy. However, various confounding factors interfere with the APOE-related AD risk, raising questions about our comprehension of the clinical findings concerning APOE. In this review, we summarize the most debated factors interacting with the APOE genotype and AD pathogenesis, depict the extent to which these factors relate to APOE-dependent AD risk, and discuss the possible underlying mechanisms.

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Section: Aging and Apoementioning

confidence: 99%