Oat-Cell Carcinoma of the Larynx

Kyriakos, Michael; Berlin, Barry P.; DeSchryver-Kecskemeti, K

doi:10.1001/archotol.1978.00790030054014

Cited by 47 publications

(6 citation statements)

References 39 publications

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“…It is essential to be determined whether it is a primary or secondary tumor. Currently, only 5 cases of secondary small cell neuroendocrine carcinoma have been described, 3 of them pulmonary, 1 prostatic, and 1 tracheal 18–20. There is also reference by Kaira et al21 of 1 case of a second primary small cell neuroendocrine carcinoma in the larynx in 2006.…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

Angouridakis¹,

Goudakos²,

Karayannopoulou³

et al. 2012

Head & Neck

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Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

Angouridakis¹,

Goudakos²,

Karayannopoulou³

et al. 2012

Head & Neck

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“…33 There are also 5 cases of laryngeal metastases from pulmonary (3 cases), tracheal (1 case), and prostatic SCNC (Table 1). [34][35][36][37][38][39] The case of prostatic carcinoma metastasizing to the vocal cord was previously reported by Têtu et al 39 In 2006, Kaira et al 19 reported a second primary SCNC of the larynx in a long-term survivor of SCNC of the lung. There are no similar reports in the literature involving the larynx.…”

Section: Incidencementioning

confidence: 99%

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

Ferlito

Rinaldo

2008

Head & Neck

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Primary laryngeal small cell neuroendocrine carcinoma (SCNC) is an unusual malignancy accounting for <0.5% of laryngeal carcinomas. To date, approximately 200 cases of primary and 5 of secondary SCNC of the larynx have been reported. This tumor most often presents in the sixth and seventh decades in men who are heavy cigarette smokers. The lesion may be associated with different paraneoplastic syndromes (ectopic adrenocorticotropic hormone syndrome, Schwartz-Bartter syndrome or syndrome of inappropriate secretion of antidiuretic hormone, and Eaton-Lambert myasthenic syndrome) or with ectopic hormone production. The diagnosis is based essentially on the histologic appearance of the tumor, confirmed by immunocytochemical investigations. Concurrent chemoradiotherapy regimens offer potential for long-term survival. This tumor is biologically aggressive, and the extent of the disease is the most significant independent prognostic factor of survival. The survival rate is similar to that with pulmonary SCNC.

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“…As of now, there are no well or moderately differentiated small cell neuroendocrine carcinomas, so SCNC is an acceptable synonym for the longer term listed above. SCNC of the larynx are uncommon but wellrecognized neoplasms (32,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49). In a review by Gnepp (49), almost three fourths of patients died of widespread metastases.…”

Section: Poorly Differentiated Neuroendocrine Carcinoma Small Cell Typementioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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Tumors exhibiting neuroectodermal differentiation occur throughout the body, and the diverse tissues of the head and neck give rise to a wide assortment of these neoplasms. Neuroectodermal neoplasms may be divided into lesions showing primarily epithelial differentiation (Group I, neuroendocrine carcinomas) and a more diverse group (Group II) of nonepithelial neoplasms. This article reviews these neuroectodermal tumors of the head and neck with emphasis on the neuroendocrine carcinomas and their nomenclature. The author believes that with regard to Group I tumors, the older terminology of carcinoid, atypical carcinoid, and small cell carcinoma should be replaced by subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma. The latter category should be further subdivided into small cell and large cell variants. Neuroendocrine carcinomas, particularly the moderately differentiated subtype, are often underdiagnosed in the head and neck region. In the larynx, these tumors are the most common form of nonsquamous carcinoma. Poorly differentiated neuroendocrine carcinoma of small cell type is most common in the salivary glands but can occur elsewhere in the region. The large cell subtype of poorly differentiated neuroendocrine carcinoma has not been well documented in this region. However, the most likely candidate for this tumor category is the so-called sinonasal undifferentiated carcinoma. Group II tumors discussed include olfactory neuroblastoma, malignant melanoma, and Ewing's sarcoma. In addition, differential diagnostic problems related to Group I and II tumors are reviewed in detail. This article reviews and updates our understanding of neuroectodermal neoplasms arising in the head and neck. The focus is on tumors that exclusively involve this region or show a strong predilection to occur here.

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Oat-Cell Carcinoma of the Larynx

Cited by 47 publications

References 39 publications

Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

Primary and secondary small cell neuroendocrine carcinoma of the larynx: A review

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

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