Obese Individuals with Asthma Preferentially Have a High IL-5/IL-17A/IL-25 Sputum Inflammatory Pattern

Marijsse, Gudrun; Seys, Sven; Schelpe, An‐Sofie; Dilissen, Ellen; Goeminne, Pieter; Dupont, Lieven; Ceuppens, Jan L.; Bullens, Dominique

doi:10.1164/rccm.201311-2011le

Cited by 70 publications

(64 citation statements)

References 6 publications

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“…Consistent with a recently published correspondence by Gudrun S. Marijsse [35], both sputum and plasma IL-17 concentrations, accompanied by airway neutrophilia, increased with increasing BMI among subjects with chronic asthma. By using Spearman rank test and multiple regression analysis, our research showed sputum, but not plasma, IL-17 was closely related to sputum neutrophil percentages, even after adjusting for multiple confounding factors, including BMI.…”

Section: Discussionsupporting

confidence: 89%

IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity

Chen

Qin

Shi

et al. 2016

Respiratory Medicine

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Section: Discussionsupporting

confidence: 89%

IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity

Chen

Qin

Shi

et al. 2016

Respiratory Medicine

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“…Sputum neutrophils but not eosinophils were higher in obese asthma than non-obese, though the relationship was only significant in the female patients. Similarly, Marijsse et al (49) also reported greater sputum neutrophils but not eosinophils in obese versus lean subjects with poorly controlled asthma. These authors and others (50) also reported greater sputum IL-17A, a cytokine important for neutrophil recruitment, in the obese than the lean patients suggesting that this cytokine may be contributing the neutrophil recruitment in these patients.…”

Section: Obesity Increases the Severity Of Asthmamentioning

confidence: 86%

“…IL-5, an eosinophil survival factor, is also elevated in sputum of obese versus lean severe asthmatics (49, 54). Thus, it is unlikely that eosinophils fail to survive within the airway lumens of obese asthmatics.…”

Section: Obesity Increases the Severity Of Asthmamentioning

confidence: 99%

Obesity and severe asthma

Tashiro

Shore

2019

Allergology International

106

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Obesity is an important global health issue for both children and adults. Obesity increases the prevalence and incidence of asthma and also increases the risk for severe asthma. Here we describe the features of severe asthma phenotypes for which obesity is a defining characteristic, including steroid resistance, airway inflammation, and co-morbidities. We also review current concepts regarding the mechanistic basis for the impact of obesity in severe asthma, including possible roles for vitamin D deficiency, systemic inflammation, and the microbiome. Finally, we describe data indicating a role for diet, weight loss, and exercise in the treatment of severe asthma with obesity. Better understanding of the mechanistic basis for the role of obesity in severe asthma could lead to new therapeutic options for this population.

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“…On the other hand, airway wall eosinophilia may be increased in obese patients with asthma and dissociated from sputum eosinophilia (38,39). Of note, IL-25, a cytokine produced by airway epithelium that is involved in the activation of type 2 innate lymphoid cells that can produce IL-5 and IL-13, is increased in the sputum of obese patients with asthma (40). These data in humans might be explained by altered trafficking of eosinophils in obesity and the participation of innate, rather than adaptive, immune responses in the development of airway eosinophilia in obese patients with asthma.…”

Section: Pre-existing Asthma Complicated By Obesitymentioning

confidence: 99%

Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

Dixon

Poynter

2016

Am J Respir Cell Mol Biol

129

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The majority of patients with severe or difficult-to-control asthma in the United States are obese. Epidemiological studies have clearly established that obese patients tend to have worse asthma control and increased hospitalizations and do not respond to standard controller therapy as well as lean patients with asthma. Less clear are the mechanistic underpinnings for the striking clinical differences between lean and obese patients with asthma. Because obesity is principally a disorder of metabolism and energy regulation, processes fundamental to the function of every cell and system within the body, it is not surprising that it affects the respiratory system; it is perhaps surprising that it has taken so long to appreciate how dysfunctional metabolism and energy regulation lead to severe airway disease. Although early investigations focused on identifying a common factor in obesity that could promote airway disease, an appreciation has emerged that the asthma of obesity is a manifestation of multiple anomalies related to obesity affecting all the different pathways that cause asthma, and likely also to de novo airway dysfunction. Consequently, all the phenotypes of asthma currently recognized in lean patients (which are profoundly modified by obesity), as well as those unique to one's obesity endotype, likely contribute to obese asthma in a particular individual. This perspective reviews what we have learned from clinical studies and animal models about the phenotypes of asthma in obesity, which show how specific aspects of obesity and altered metabolism might lead to de novo airway disease and profoundly modify existing airway disease.

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Obese Individuals with Asthma Preferentially Have a High IL-5/IL-17A/IL-25 Sputum Inflammatory Pattern

Cited by 70 publications

References 6 publications

IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity

IL-17 protein levels in both induced sputum and plasma are increased in stable but not acute asthma individuals with obesity

Obesity and severe asthma

Mechanisms of Asthma in Obesity. Pleiotropic Aspects of Obesity Produce Distinct Asthma Phenotypes

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