Obese patients with sleep apnea syndrome treated by progesterone.

Kimura, Hiroshi; Tatsumi, Kouichiro; Kunitomo, Fumio; Okita, Shinya; Tojima, Hirokazu; Kouchiyama, Shiro; Masuyama, Shigeru; Shinozaki, Toshihide; Mikami, Makoto; Watanabe, Shohei; Ishikawa, You; Honda, Yoshiyuki; Kuriyama, Takayuki

doi:10.1620/tjem.156.suppl_151

Cited by 17 publications

(7 citation statements)

References 17 publications

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“…A role for progesterone in pregnancy-associated respiratory stimulant activity has been reported (Slatkovska et al, 2006) and furthermore, progesterone is used as an effective respiratory stimulant in patients with breathing disorders (Dempsey & Skatrud, 1986; Kimura et al, 1988; Tatsumi, 1999). Studies have also shown a neuroprotective role for progesterone and estrogen in sleep-disordered breathing in post-menopausal women.…”

Section: Contribution Of Sex Steroids To Airway Structure and Funcmentioning

confidence: 99%

Sex steroid signaling: Implications for lung diseases

Sathish

Martin

Prakash

2015

Pharmacology & Therapeutics

144

134

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There is increasing recognition that the sex hormones (estrogen, progesterone, and testosterone) have biological and pathophysiological actions in peripheral, non-reproductive organs, including the lung. Clinically, sex differences in the incidence, morbidity and mortality of lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, lung cancer and pulmonary hypertension have been noted, although intrinsic sex differences vs. the roles of sex steroids are still not well-understood. Accordingly, it becomes important to ask the following questions: 1) Which sex steroids are involved? 2) How do they affect different components of the lung under normal circumstances? 3) How does sex steroid signaling change in or contribute to lung disease, and in this regard, are sex steroids detrimental or beneficial? As our understanding of sex steroid signaling in the lung improves, it is important to consider whether such information can be used to develop new therapeutic strategies to target lung diseases, perhaps in both sexes or in a sex-specific manner. In this review, we focus on the basics of sex steroid signaling, and the current state of knowledge regarding how they influence structure and function of specific lung components across the life span and in the context of some important lung diseases. We then summarize the potential for sex steroids as useful biomarkers and therapeutic targets in these lung diseases as a basis for future translational research in the area of gender and individualized medicine.

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Section: Contribution Of Sex Steroids To Airway Structure and Funcmentioning

confidence: 99%

Sex steroid signaling: Implications for lung diseases

Sathish

Martin

Prakash

2015

Pharmacology & Therapeutics

144

134

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“…However, there are few data on this approach. Reports of initial positive results with either progesterone (77), almitrine (78), or acetazolamide (28) have never resulted in ongoing randomized controlled trials. Furthermore, medroxyprogesterone can increase the risk of venous thromboembolism (79,80).…”

Section: Pharmacological Respiratory Stimulationmentioning

confidence: 99%

Assessment and Management of Patients with Obesity Hypoventilation Syndrome

Mokhlesi

Kryger²,

Grunstein³

2008

Proceedings of the American Thoracic Society

224

108

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Obesity hypoventilation syndrome (OHS) is characterized by obesity, daytime hypercapnia, and sleep-disordered breathing in the absence of significant lung or respiratory muscle disease. Compared with eucapnic morbidly obese patients and eucapnic patients with sleep-disordered breathing, patients with OHS have increased health care expenses and are at higher risk of developing serious cardiovascular disease leading to early mortality. Despite the significant morbidity and mortality associated with this syndrome, diagnosis and institution of effective treatment occur late in the course of the syndrome. Given that the prevalence of extreme obesity has increased considerably, it is likely that clinicians will encounter patients with OHS in their clinical practice. Therefore maintaining a high index of suspicion can lead to early recognition and treatment reducing the high burden of morbidity and mortality and related health care expenditure associated with undiagnosed and untreated OHS. In this review we define the clinical characteristics of the syndrome and review the pathophysiology, morbidity, and mortality associated with it. Last, we discuss currently available treatment modalities.

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“…It has been proposed that relative duration of the desaturation period in total sleep time is a relevant determinant. Such evaluation might have resolved, at least in part, the apparent discrepancies in previous studies [84]. In general, patients with obstructive sleep apnea are most effectively treated with the promising continuous positive airway pressure (CPAP) and/or surgery.…”

Section: C) Use Of Progesterone In the Treatment Of Sleepdisordered mentioning

confidence: 99%

“…Using chlormadinone acetate, a respiratory stimulant known to increase not only CO 2 and hypoxic chemosensitivity but also respiratory drive response for ventilatory loading, Kimura et al [84] tested its possible beneficial effect in nine sleep apneic patients. The data indicate that chlormadinone acetate was effective in patients suffering of sleep apnea syndrome (reduced apnea and hypoxic episodes) whose load response as well as respiratory control activity are augmented during wakefulness.…”

Section: C) Use Of Progesterone In the Treatment Of Sleepdisordered mentioning

confidence: 99%

Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

Andersen¹,

Bittencourt²,

Antunes

et al. 2006

CMC

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Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. The literature also contains a substantial amount of data on the effect of apnea in women with obesity-hypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.

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Obese patients with sleep apnea syndrome treated by progesterone.

Cited by 17 publications

References 17 publications

Sex steroid signaling: Implications for lung diseases

Sex steroid signaling: Implications for lung diseases

Assessment and Management of Patients with Obesity Hypoventilation Syndrome

Effects of Progesterone on Sleep: A Possible Pharmacological Treatment for Sleep-Breathing Disorders?

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