Obesity and breast cancer risk for pre- and postmenopausal women among over 6 million Korean women

Park, Jae Won; Han, Kyungdo; Shin, Dong Wook; Yeo, Yohwan; Chang, Jiwon; Yoo, Jung Eun; Jeong, Su‐Min; Lee, Se-Kyung; Ryu, Jai Min; Park, Young Jun

doi:10.1007/s10549-020-05952-4

Cited by 45 publications

(30 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The findings from Park et al. are largely consistent with data from the literature in Asian and Western populations [2] , [3] , [4] and highlight the importance of considering ethnic variation with respect to associations of obesity with cancer risk [4] .…”

supporting

confidence: 79%

It's not just size that matters: Challenges in studying obesity and female-specific cancers

Clarke

2021

The Lancet Regional Health - Western Pacific

View full text Add to dashboard Cite

supporting

confidence: 79%

It's not just size that matters: Challenges in studying obesity and female-specific cancers

Clarke

2021

The Lancet Regional Health - Western Pacific

View full text Add to dashboard Cite

“…based on the medical expense that medical service providers charge for their medical expenditures), prescription information, and health examinations (results of cardiovascular and cancer screening) [20,21]. Many previous epidemiological studies have used this database and its details have been described elsewhere [22,23].…”

Section: Data Sourcementioning

confidence: 99%

“…This study compared 2009-2010 and 2011-2012 results of the national health screening program [22,23]. Using changes in MetS status during the continuous biennial checkup, participants were categorized into four groups: sustained non-MetS, transition to MetS, transition to non-MetS, and sustained MetS.…”

Section: Independent Variablesmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Metabolic Syndrome Status and Breast Cancer Risk: A Nationwide Cohort Study

Choi

Chun

Shin

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

Objective: To our knowledge, no studies have yet looked at how the risk of developing breast cancer (BC) varies with changes in metabolic syndrome (MetS) status. This study aimed to investigate the association between changes in MetS and subsequent BC occurrence. Research Design and Methods: We enrolled 930,055 postmenopausal women aged 40–74 years who participated in a biennial National Health Screening Program in 2009–2010 and 2011–2012. Participants were categorized into four groups according to change in MetS status during the two-year interval screening: sustained non-MetS, transition to MetS, transition to non-MetS, and sustained MetS. We calculated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for BC incidence using the Cox proportional hazards models. Results: At baseline, MetS was associated with a significantly increased risk of BC (aHR 1.11, 95% CI 1.06–1.17) and so were all of its components. The risk of BC increased as the number of the components increased (aHR 1.46, 95% CI 1.26–1.61 for women with all five components). Compared to the sustained non-MetS group, the aHR (95% CI) for BC was 1.11 (1.04–1.19) in the transition to MetS group, 1.05 (0.96–1.14) in the transition to non-MetS group, and 1.18 (1.12–1.25) in the sustained MetS group. Conclusion: Significantly increased BC risk was observed in the sustained MetS and transition to MetS groups. These findings are clinically meaningful in that efforts to recover from MetS may lead to reduced risk of BC.

show abstract

“…For breast cancer, several large studies have shown an increased risk of breast cancer with weight gain in post-menopausal women (7,8). In Korea, nationwide studies have confirmed that obesity increases the risk of breast cancer in post-menopausal women (9). Notably, the peak age for breast cancer is between 40 and 50 years in Asian countries, whereas in the western countries, itis between 50 and 70 years (10).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Susceptibility to Breast Cancer in Korean Women With Elevated Serum Gamma-Glutamyltransferase Levels: A Nationwide Population-Based Cohort Study

Seol

Wang²,

Han³

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

BackgroundThe incidence of breast cancer has been gradually increasing in Korea. Recently, the elevated level of serum gamma-glutamyltransferase (GGT) has emerged to be associated with the development and progression of some malignancies. This study aimed to determine the effect of serum GGT levels on the risk of developing breast cancer in Korean women.MethodsWe used National Health Insurance Service Health Checkup data to examine the association between serum GGT levels and breast cancer development in Korean women. Women aged 40 years or older who participated in the Korean National Health Screening Examination between January 2009 and December 2009 and who did not develop any cancer within 1-year post examination were included in this analysis (n = 3,109,506). Cox proportional hazard regression analysis was conducted to calculate hazard ratios (HRs) with 95% confidence intervals (CIs).ResultsOverall, an elevated serum GGT level was associated with the increased risk of developing breast cancer; compared to the Q1 group, the Q4 group showed a significantly increased breast cancer risk (HR: 1.120,95% CI: 1.08–1.162). Such a relationship was stronger in post-menopausal women than pre-menopausal women (HR: 1.173, 95% CI: 1.107–1.243; HR: 1.070, 95% CI:1.019–1.124). Women with a high GGT level (Q4) were also at an increased risk of developing carcinoma in situ (CIS) (HR: 1.114, 95% CI: 1.04–1.192). In post-menopausal women, the Q4 group also exhibited higher CIS risk (HR: 1.266, 95% CI: 1.132–1.416). However, no significant difference in the risk of developing CIS was observed between the Q1 and Q4 groups in pre-menopausal women. Further analysis revealed that obese, post-menopausal women with a high GGT level (Q4) were associated with an increased risk of developing breast cancer (HR: 1.214, 95% CI: 1.125–1.31) and CIS (HR: 1.348, 95% CI: 1.159–1.569).ConclusionsOur study results demonstrate that increased serum GGT level is a risk factor for developing breast cancer. The post-menopausal women group with obesity and elevated serum GGT level showed the highest incidence of breast cancer. Thus, serum GGT concentration could be a novel and potential risk factor for breast cancer. Further validation in different ethnic groups would be warranted.

show abstract

Obesity and breast cancer risk for pre- and postmenopausal women among over 6 million Korean women

Cited by 45 publications

References 60 publications

It's not just size that matters: Challenges in studying obesity and female-specific cancers

It's not just size that matters: Challenges in studying obesity and female-specific cancers

Changes in Metabolic Syndrome Status and Breast Cancer Risk: A Nationwide Cohort Study

Enhanced Susceptibility to Breast Cancer in Korean Women With Elevated Serum Gamma-Glutamyltransferase Levels: A Nationwide Population-Based Cohort Study

Contact Info

Product

Resources

About