Obesity and Diabetes as Risk Factors for Severe Plasmodium falciparum Malaria: Results From a Swedish Nationwide Study

Wyss, Katja; Wångdahl, Andreas; Vesterlund, Maria; Hammar, Ulf; Dashti, Saduddin; Nauclér, Pontus; Färnert, Anna

doi:10.1093/cid/cix437

Cited by 61 publications

(53 citation statements)

References 34 publications

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“…Monte et al [10] research findings however elucidated otherwise, it was observed in the study that high BMI, obesity and diabetes acts as protective factor against malaria. Katja et al [11] proved a total contrast to our finding, the study showed that BMI, obesity and diabetes are factors that increased malaria parasitemia. All of the forgoing studies are linked to physiological sociodemographic indices.…”

Section: Discussioncontrasting

confidence: 94%

“…IL-10 modulates this pro-inflammatory response [18]. TFN-α have been shown to correlate with malaria severity in several studies [16,20,11], low levels of TNF-α levels were observed in our study. This could be explained by the negative action of IL-10 on pro-inflammatory responses.…”

Section: Discussionsupporting

confidence: 63%

“…Furthermore, the relative levels of pro-and antiinflammatory cytokines are essential mediators of malaria anemia production and outcomes [26,4]. Early production of pro-inflammatory T-helper 1 (Th1) cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-12 and interferon (IFN)-gamma may limit progression to severe complications from uncomplicated malaria [10,11]. They actually limit the growth of parasites and stimulate monocyte phagocytosis to improve clearance of parasitized erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

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Pro- and anti-inflammatory immune response profiling prevents severe malaria among Nigerians infected with Plasmodium falciparum: the future for malaria vaccines and therapeutics.

Okpokor¹,

Peter²,

Ajibaye³

et al. 2020

Preprint

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Background Available evidence indicates that the various stages of the malaria parasite life cycle have specific immune responses. The pro-inflammatory cytokines tend to play an important role in preventing malaria and killing the parasites. Furthermore, the relative levels of pro-and anti-inflammatory cytokines are essential mediators of malaria anemia production and outcomes. Natural human immune responses to malaria recognize extracellular sporozoites and merozoites, both of which have surface-exposed antigens, and which are currently being developed for various vaccines. Methods A total of four hundred sixty- two (462) participants were tested for Plasmodium falciparum. The procedure employed were parasite staining using World Health Organization parasitology laboratory protocol [Microscopy] of Giemsa staining and Enzyme linked immunosorbent assay [ELISA]. Results The subjects in this study showed high levels of INF-γ and TNF-α which decreases with increased malaria severity and high parasite density. These results suggest that INF-γ cytokine and TNF-α may contribute to protection against severe malaria anaemia and parasite clearance. Conversely, infected participants showed higher levels of IL-10, which decreases with severe malaria parasite, furthermore IL-10 levels correlated with parasite density. These findings suggest that higher levels of anti-inflammatory cytokines, especially IL-10 levels may contribute to pathogenesis of complicated malaria by inhibiting the INF-γ and TNF-α production. Conclusion Molecular biological and other serological analysis are needed to elucidate the implication of these cytokines and other pro-inflammatory cytokines as IL-17, IL-21 and IL-22 in the responses to malaria and consequently their involvement in malaria vaccine construct/development as well as other therapeutics for the treatment and elimination of the malaria parasite in our environment.

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Section: Discussioncontrasting

confidence: 94%

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

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Pro- and anti-inflammatory immune response profiling prevents severe malaria among Nigerians infected with Plasmodium falciparum: the future for malaria vaccines and therapeutics.

Okpokor¹,

Peter²,

Ajibaye³

et al. 2020

Preprint

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“…La escasa información y este hallazgo invitan a estudiar más la diabetes y otras enfermedades no transmisibles en la región de la Amazonía. Si bien esta región se ha caracterizado principalmente por enfermedades infectocontagiosas, estas también pueden coexistir o aumentar el riesgo de patologías crónicas no transmisibles (28)(29)(30)(31)(32)(33) .…”

Section: Perudiab (2010-12) (23)unclassified

“…La interacción de la diabetes mellitus tipo 2 con otras enfermedades de causa infecciosa o transmitida por vectores parece relevante en el contexto peruano, en el cual la diversidad de climas, regiones y factores sociodemográficos todavía hacen de las enfermedades infectocontagiosas un problema de salud pública. Se ha estudiado bastante sobre la interacción entre diabetes y tuberculosis (42) ; por otra parte, recientemente se ha propuesto que la diabetes puede aumentar el riesgo o severidad de la malaria (28)(29)(30)(31)(32)(33) . Para el primer ejemplo (diabetes y tuberculosis) parece que el contexto es adecuado para nuevos estudios de intervención o implementación.…”

Section: Investigación En Diabetes: Siguientes Pasosunclassified

Diabetes mellitus tipo 2 en Perú: una revisión sistemática sobre la prevalencia e incidencia en población general

Carrillo‐Larco

Bernabé‐Ortiz

2019

Rev Peru Med Exp Salud Publica

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Objetivos. Identificar estudios de prevalencia e incidencia de diabetes mellitus tipo 2 en población general adulta de Perú. Materiales y métodos. Se evaluaron estudios observacionales que incluyeron individuos de población general seleccionados aleatoriamente. La definición de diabetes debió incluir al menos un parámetro de laboratorio (p. ej. glucosa basal). Se revisó LILACS, SciELO, Scopus, Medline, Embase y Global Health, sin restricciones. El riesgo de sesgo se evaluó con la escala Newcastle-Ottawa. Resultados. La búsqueda identificó 909 resultados, adicionalmente se agregó un artículo de otra fuente. Luego de evaluar los resultados, se seleccionaron 20 artículos que representaron nueve estudios (n=16 585). Uno de los estudios fue de alcance nacional y otro seminacional (ENINBSC, 2004-05 y PERUDIAB, 2010-12); el primero reportó una prevalencia de 5,1% en sujetos ≥35 años, mientras que el segundo reportó 7,0% en sujetos ≥25 años. Otros estudios se enfocaron en poblaciones de una o varias ciudades del país, o en grupos poblacionales selectos, como el estudio PERU MIGRANT (2007-08) que reportó la prevalencia de diabetes en sujetos de zonas rurales (0,8%), en migrantes de zonas rurales a urbanas (2,8%), y en zonas urbanas (6,3%). Tres estudios realizaron seguimiento prospectivo, siendo uno de ellos el PERUDIAB: incidencia acumulada de 19,5 nuevos casos por 1000 personas al año. El riesgo de sesgo fue bajo en todos los estudios. Conclusiones. Estudios poblacionales señalan que la prevalencia de diabetes ha aumentado y se registran aproximadamente dos casos nuevos por cada cien personas al año. La evidencia aún es escasa en la selva y en poblaciones rurales.

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Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology

Anstey

Grigg

Rajahram

et al. 2021

Advances in Parasitology

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Obesity and Diabetes as Risk Factors for Severe Plasmodium falciparum Malaria: Results From a Swedish Nationwide Study

Cited by 61 publications

References 34 publications

Pro- and anti-inflammatory immune response profiling prevents severe malaria among Nigerians infected with Plasmodium falciparum: the future for malaria vaccines and therapeutics.

Pro- and anti-inflammatory immune response profiling prevents severe malaria among Nigerians infected with Plasmodium falciparum: the future for malaria vaccines and therapeutics.

Diabetes mellitus tipo 2 en Perú: una revisión sistemática sobre la prevalencia e incidencia en población general

Knowlesi malaria: Human risk factors, clinical spectrum, and pathophysiology

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