Obesity and diabetes: lipids, ‘nowhere to run to'

Abstract

Although specific pathogenic entities contributing to diabetic risk, such as central adiposity, ectopic fat accumulation, hyperlipidaemia and inflammation, are well-characterized, the response of cellular systems to such insults are less well understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors.

Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism

“…Type 2 diabetes, in particular, is a metabolic disorder characterized by high blood glucose levels that result from defects in insulin action (Hill et al, 2009). It is caused by the non-responsiveness of body cells to insulin rather than by defective insulin production (Fadini et al, 2005).…”

Orchestrated downregulation of genes involved in oxidative metabolic pathways in obese vs. lean high-fat young male consumers

“…Obesity is strongly associated with different illnesses such as type 2 diabetes and cardiovascular diseases (14,23). Increasing prevalence of obesity has been proposed to be a consequence of both increased energy availability and reduced energy expenditure superimposed on a genetic background evolved for survival in conditions of food deprivation (30).…”

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

“…[31]. It is now widely recognized that a high calorie western food diet contributes greatly to the development of metabolic syndrome [32,33]. Recent literature suggested that diets with high content of fat and simple carbohydrate, especially fructose, are strongly associated with insulin resistance [34][35][36].…”