Obesity and Diabetic Complications: A Study from the Nationwide Diabetes Report of the National Program for Prevention and Control of Diabetes (NPPCD-2021) Implications for Action on Multiple Scales

Moosaie, Fatemeh; Ghaemi, Fatemeh; Mechanick, Jeffrey; Shadnoush, Mahdi; Firouzabadi, Fatemeh Dehghani; Kermanchi, Jamshid; Poopak, Amirhossein; Esteghamati, Sadaf; Forouzanfar, Reza; Abhari, Seyede Marzieh Fatemi; Mansournia, Mohammad Alì; Khosravi, Ahmad; Gholami, Emad; Nakhjavani, Manouchehr; Esteghamati, Alireza

doi:10.1016/j.pcd.2022.03.009

Cited by 19 publications

(9 citation statements)

References 53 publications

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“…This contrasts with our findings, where participants with T2DM who were overweight had a more threatening view of the illness compared to those of normal weight [27]. Obesity has a significant impact on the development of macrovascular and microvascular complications in T2DM [28], which in turn affects patients' quality of life and perception of the disease [29]. Sayón-Orea et al (2018) corroborate our findings, as in their study, participants with normal weight and chronic illness were less likely to report poor health than those with overweight or obesity and chronic disease, particularly if they had been diagnosed with hypertension and T2DM [30].…”

Section: Discussioncontrasting

confidence: 99%

Cognitive and Emotional Perceptions of Illness in Patients Diagnosed with Type 2 Diabetes Mellitus

Gosak,

Stiglic

2024

Healthcare

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Type 2 diabetes mellitus (T2DM) affects a patient’s physical, social, and mental well-being. Perceptions of the illness are linked to quality of life. The aim of this study was to assess illness perception in patients diagnosed with T2DM and to validate the Brief Illness Perception Questionnaire in the Slovenian language. A cross-sectional study involved 141 patients diagnosed with T2DM. We performed a content analysis of the questionnaire and estimated the S-CVI, I-CVI, kappa coefficient. We also used Cronbach’s alpha to assess the reliability. Participants did not have a very threatening perception of T2DM, but being overweight and having cardiovascular disease were significant contributors to a more threatening perception. The most frequently indicated factors influencing the onset and development of T2DM were heredity and genetics, stress and other psychological distress, and poor and inadequate nutrition. I-CVI ranged from 0.833 to 1.00, while the kappa is greater than 0.74, confirming the excellent validity of the questions. The content validity assessment of the questionnaire further confirms that the questionnaire is suitable for use with the target population in Slovenia. The questionnaire proved to be a valid and reliable tool that can be used to assess the relationship between illness perception and self-management of T2DM.

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Section: Discussioncontrasting

confidence: 99%

Cognitive and Emotional Perceptions of Illness in Patients Diagnosed with Type 2 Diabetes Mellitus

Gosak,

Stiglic

2024

Healthcare

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“…A study from the Nationwide Diabetes Report of the National Program for Prevention and Control of Diabetes, including > 100,000 patients with T2DM, reported that obesity was independently associated with microvascular complications [ 67 ]. The European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study suggested a positive linear association between pre-diagnosis BMI and risk of microvascular complications [ 68 ].…”

Section: Effect Of Obesity Treatment In Micro- and Macrovascular Comp...mentioning

confidence: 99%

Treat Obesity to Treat Type 2 Diabetes Mellitus

Sulu,

Yumuk

2024

Diabetes Ther

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Obesity, a multifactorial, relapsing chronic disease, serves as a gateway to a spectrum of metabolic, cardiovascular, mechanical and mental health problems. Over the last few decades, the global prevalence of obesity has surged nearly threefold, mirroring the escalating rates of type 2 diabetes mellitus (T2DM). This parallel trajectory strongly suggests a cause-and-effect relationship between obesity and T2DM. Extensive research indicates that even modest weight gain elevates the risk of T2DM, favoring the notion of obesity being a root cause. This perspective finds robust support in numerous studies demonstrating the preventive effects of obesity management on the onset of T2DM. Beyond prevention, obesity management has been shown to enhance remission in individuals with T2DM and to decrease microvascular complications, cardiovascular risk factors, renal failure and heart failure. This evidence underpins the urgent need for global initiatives aimed at addressing obesity management as a key strategy in the prevention and management of T2DM and its complications.

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“…Diabetes mellitus (DM) is a chronic, metabolic disease characterized by elevated levels of blood glucose, which leads over time to serious damage to the heart, blood vessels, eyes, kidneys and nerves. Concern regarding this chronic disease is the complications which can affect multiple vital organ systems, thereby leading to more severe and irreversible pathological conditions such as nephropathy, retinopathy, vasculopathy, neuropathy and cardiovascular diseases, as well as hepatopathy [1][2][3] . Research indicates that DM is associated with a number of liver abnormalities, such as abnormal glycogen deposition, non-alcoholic fatty liver disease (NAFLD), fibrosis, cirrhosis, hepatocellular carcinomas (HCCs), abnormal elevated hepatic enzymes, acute liver disease and viral hepatitis [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Comparative study of aqueous, methanol and petroleum ether extracts of unripe Carica papaya seed on liver and kidney function in streptozotocin-induced diabetic rats

Nnaemeka¹,

Ukamaka²,

God’swealth³

et al. 2023

GSC Biol. Pharm. Sci.

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Background: Diabetes as chronic disease has serious complications which can affect multiple vital organ systems, thereby leading to more severe and irreversible pathological conditions. This study investigated the hepatoprotective and nephroprotective potentials of unripe Carica papaya (UCP) seed extract in diabetic rats using three different solvents. Methods: Thirty adult male Wistar rats were used. Twenty-five out of thirty were induced with diabetes following an overnight fast, by a single intravenous injection of 60 mg/kg STZ. The rats were grouped into six groups (n=5):NC: normal control, DC: diabetic control, DSTD: diabetic and treated with glibenclaimide, aqueous (DAUCP), methanol (DMUCP) and petroleum ether (DPEUCP) rats were induced but treated with 200 mg of aqueous, methanol and petroleum ether extract of UCP seed extract respectively. The extracts were administered to the animals orally for 21 days. Results: The animals administered with different extracts showed significant decrease (P<0.05) in blood sugar level, ALT, AST, ALP, γ-GT, urea, creatinine, BUN, total and direct bilirubin and an increase level in total protein, albumin, globulin and sodium, potassium, bicarbonate and chloride when compared to the diabetic control group. Conclusion: It can be inferred from that data that the extracts have hepatoprotective and nephroprotective potentials on the liver and kidney. This implies that unripe C. papaya seed can be effectively used in the management of diabetes.

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Obesity and Diabetic Complications: A Study from the Nationwide Diabetes Report of the National Program for Prevention and Control of Diabetes (NPPCD-2021) Implications for Action on Multiple Scales

Cited by 19 publications

References 53 publications

Cognitive and Emotional Perceptions of Illness in Patients Diagnosed with Type 2 Diabetes Mellitus

Cognitive and Emotional Perceptions of Illness in Patients Diagnosed with Type 2 Diabetes Mellitus

Treat Obesity to Treat Type 2 Diabetes Mellitus

Comparative study of aqueous, methanol and petroleum ether extracts of unripe Carica papaya seed on liver and kidney function in streptozotocin-induced diabetic rats

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