Obesity and Disease: Hormones and Obesity

Pinkney, Jonathan

doi:10.1002/9780470987087.ch14

Cited by 2 publications

(3 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, both total and free testosterone concentrations are low, although gonadotrophins are usually normal, indicating that obesity-related biochemical hypogonadism is most probably clinically insignificant. 97 Of course, caution needs to be exercised in interpreting such data in the presence of hypothalamic or pituitary pathology.…”

Section: Management Of Obesitymentioning

confidence: 99%

Overview of human obesity and central mechanisms regulating energy homeostasis

Crowley

2008

Ann Clin Biochem

View full text Add to dashboard Cite

Obesity is now regarded as a global epidemic affecting both adults and children, and is associated with significant morbidity and mortality. Thus the effective management of obesity has become an important clinical focus. Therefore, an understanding of the pathways controlling appetite, satiety and food intake is critical for gaining an insight into the pathogenesis of obesity and also for the development of diagnostic tests and therapeutic agents for use in the clinical management of this condition. Over the last decade or more research using both mouse and human genetic models has elucidated the critical role of the leptin-melanocortin pathway in the hypothalamus, in regulating mammalian energy balance. In tandem with this, a clearer understanding of the regulation of gut-derived hormones and their interaction with the central nervous system has further illuminated the complex interplay between central and peripheral aspects of energy regulation. The obesity epidemic and the expanded knowledge base relating to its aetiopathogenesis have specific implications for clinical biochemistry. In particular, an increase in workload may be expected due to biochemical investigation of obesity and its co-morbidities. Moreover, advice on the in-depth investigation of complex cases of obesity may be sought, including information on newer diagnostic tests, such as serum leptin or molecular genetic analysis. There may also be a substantive role for chemical pathologists in establishing and running clinical obesity services. Finally, clinical biochemistry has a role in research pertaining to obesity and cardiometabolic risk.

show abstract

Section: Management Of Obesitymentioning

confidence: 99%

Overview of human obesity and central mechanisms regulating energy homeostasis

Crowley

2008

Ann Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Von diesen Abnormalitäten ist die defiziente Wachstumshormon-Sekretion für die weitere Gewichtszunahme relevant (Pinkney 2005). Schilddrüsenhormone regulieren den Energiestoffwechsel.…”

Section: Adipositas Wachstumshormon Und Schilddrüsenhormoneunclassified

“…Als Folge der verringerten SHBG-Produktion kommt es einer Erhöhung der freien Geschlechtshormone und deren verstärktem Abbau. Bei Männern mit Adipositas führt das hauptsächlich zu erniedrigten Testosteronspiegeln, die über eine Verringerung der lipolytischen Aktivität im Fettgewebe zur weiteren Fettakkumulation beitragen können (Pinkney 2005).…”

Section: Adipositas Und Geschlechtshormoneunclassified

Adipositas und Endokrinium

Blüher¹

2012

Adipositas-Management in Anästhesie, Chirurgie, Intensivmedizin Und Notfallmedizin

View full text Add to dashboard Cite

Obesity and Disease: Hormones and Obesity

Cited by 2 publications

References 102 publications

Overview of human obesity and central mechanisms regulating energy homeostasis

Overview of human obesity and central mechanisms regulating energy homeostasis

Adipositas und Endokrinium

Contact Info

Product

Resources

About