Obesity and Dyslipidemia in Chinese Adults: A Cross-Sectional Study in Shanghai, China

Zhu, Junjie; Zhang, Yue; Wu, Yi‐Ling; Xiang, Yu; Tong, Xin; Yu, Yuting; Qiu, Yunping; Cui, Shuheng; Zhao, Qi; Wang, Na; Jiang, Yonggen

doi:10.3390/nu14112321

“…Another study of Chinese adults showed that obese males also had a higher risk of dyslipidemia than females [29] . This sex disparity may be due to differences in lifestyle between males and females, which are risk factors of dyslipidemia [30] .…”

Section: Discussionmentioning

confidence: 99%

Multi-trajectories of body mass index, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study

Zhang,

Guan,

Gou

et al. 2024

Preprint

0

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Background: Evidence is insufficient to establish a longitudinal association between combined trajectories of body mass index (BMI) and waist circumference (WC) and dyslipidemia. Our study aimed to explore the association between multi-trajectories of BMI and WC and incident dyslipidemia and identify microbiota and metabolite signatures of these trajectories. Methods: Stratified by sex, we used a group-based trajectory modeling approach to identify distinct multi-trajectories of BMI and WC among 10,678 participants from the China Health and Nutrition Survey over a 24-year period. For each sex, we examined the associations between these multi-trajectories (1991-2015) and the onset dyslipidemia (2018) using multivariable logistic regression adjusting for sociodemographic and lifestyles factors. We characterized the gut microbial composition and performed LASSO and logistic regression to identify gut microbial signatures associated with these multi-trajectories in males and females, respectively. Results: We identified four multi-trajectories of BMI and WC among both males and females: Normal (Group 1), BMI&WC normal increasing (Group 2), BMI&WC overweight increasing (Group 3), and BMI&WC obesity increasing (Group 4). Among males, Group 2 (OR: 2.10, 95% CI: 1.28–3.46), Group 3 (OR: 2.69, 95% CI: 1.56–4.63) and Group 4 (OR: 3.56, 95% CI: 1.85–6.83) had higher odds of developing dyslipidemia. However, among females, only those in Group 2 (OR: 1.54, 95% CI: 1.03–2.30) were more likely to develop dyslipidemia. In males, compared with Group 1, we observed lower alpha-diversity within Groups 2,3, and 4, and significant beta-diversity differences within Groups 3 and 4 (p ＝ 0.001). We also identified 3, 8, and 4 characteristic bacterial genera in male Groups 2, 3 and 4, and 2 genera in female Group 2. A total of 23, 25 and 10 differential metabolites were significantly associated with the above genera, except for Group 2 in males. Conclusions: The ascending combined trajectories of BMI and WC are associated with a higher risk of dyslipidemia, even with normal baseline levels, especially in males. Shared and unique gut microbial and metabolic signatures among these high-risk trajectories could enhance our understanding of the mechanisms connecting obesity to dyslipidemia.

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“…[ 3 , 53 ] Moderate or central obesity subjects have been found to have higher levels of TC, TG, LDL-C, and lower levels of HDL-C compared with nonobese individuals, which may be associated with excess visceral fat in the abdomen. [ 54 , 55 ] There is a strong correlation between overweight or obesity and cardiovascular events and dyslipidemia, and effective control of lipid levels is expected to reduce the incidence of metabolic morbidity and death. [ 56 , 57 ]…”

Section: Discussionmentioning

confidence: 99%

“…[3,53] Moderate or central obesity subjects have been found to have higher levels of TC, TG, LDL-C, and lower levels of HDL-C compared with nonobese individuals, which may be associated with excess visceral fat in the abdomen. [54,55] There is a strong correlation between overweight or obesity and cardiovascular events and dyslipidemia, and effective control of lipid levels is expected to reduce the incidence of metabolic morbidity and death. [56,57] Concerning the biochemical indicators outcomes, our meta-analysis showed large significant improvement in LDL, moderate significant improvement in TG, small significant improvement in TC and HDL of TCE intervention on the biochemical indicators outcomes.…”

Section: Effects Of Tce On Biochemical Indicators Outcomesmentioning

confidence: 99%

Efficacy of traditional Chinese exercises in improving anthropometric and biochemical indicators in overweight and obese subjects: A systematic review and meta-analysis

Wang

¹

,

Pan

²

,

Yang

³

2023

Medicine

1

0

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Background: The efficacy of traditional Chinese exercise (TCE)-based intervention in the improvement of anthropometric and biochemical indicators in overweight and obese patients is controversial. In this regard, the aim of this review was to summarize the evidence of TCE interventions to evaluate their effectiveness on the anthropometric and biochemical indicators of overweight and obese patients. Method: Five databases were systematically searched for relevant articles published from inception to October 2022. Randomized controlled trials examining TCE intervention in overweight and obese patients The treatment effects were estimated using a random-effect meta-analysis model with standardized mean differences (Hedges’ g ). The categorical and continuous variables were used to conduct moderator analyses. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) (identifier CRD42022377632). Result: Nine studies involving a total of 1297 participants were included in the final analysis. In the anthropometric indicators outcomes, the meta-analytic findings revealed large and significant improvements in body mass index ( g = 1.44, 95% confidence interval [CI] = 1.27–1.61, P = .000, I 2 = 99%), weight ( g = 1.47, 95% CI = 1.25–1.68, P = .000, I 2 = 95%), fat percentage ( g = 1.22, 95% CI = 0.52–1.93, P = .000, I 2 = 93%), and small and significant improvements in waist circumference ( g = 0.38, 95% CI = 0.21–0.54, P = .000, I 2 = 99%). In the biochemical indicators outcomes, the findings revealed large and significant improvements in low density lipoprotein ( g = 2.08, 95% CI = 1.80–2.37, P = .000, I 2 = 98%), moderate and significant improvements in triglyceride ( g = 0.69, 95% CI = 0.56–0.81, P = .000, I 2 = 96%), small and significant improvements in total cholesterol ( g = 0.37, 95% CI = 0.19–0.54, P = .000, I 2 = 77%), and high-density lipoprotein ( g = −0.71, 95% CI = −0.86 to 0.57, P = .000, I 2 = 99%). The moderator shows that the effects of TCE on anthropometric and biochemical indicators were moderated by frequency of exercise, exercise duration, and type of control group. Conclusion: TC...

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“…In 2016, the Joint Committee of Guidelines for the Prevention and Treatment of Dyslipidemia in Chinese Adults reported that the overall prevalence of dyslipidemia in Chinese adults was 40.4%. They projected that the prevalence of dyslipidemia and related disease burden among Chinese adults is expected to increase [11]. Moreover, dyslipidemia in Chinese adults and non-high-density lipoprotein (nonHDL-C) were predicted to be important risk factors of cardiovascular disease [11].…”

Section: Introductionmentioning

confidence: 99%

“…They projected that the prevalence of dyslipidemia and related disease burden among Chinese adults is expected to increase [11]. Moreover, dyslipidemia in Chinese adults and non-high-density lipoprotein (nonHDL-C) were predicted to be important risk factors of cardiovascular disease [11]. NonHDL-C and nonHDL-C / HDL-C (high-density lipoprotein) are now being studied in relation to the occurrence of dyslipidemia [12].…”

Section: Introductionmentioning

confidence: 99%

Association of dyslipidemia with lumbar disc herniation: A case-control study

Tan

¹

,

Xiang

²

,

Hu

³

et al. 2023

Preprint

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Purpose: The purpose of this study was to investigate the relationship between dyslipidemia and lumbar disc herniation (LDH). Methods: A total of 269 patients with LDH and 269 patients with lumbar vertebral fracture (LVF) were enrolled in this study. The total cholesterol level (TC), Low-density lipoprotein-cholesterol level (LDL-C), triglyceride level (TG), High-density lipoprotein-cholesterol level (HDL-C), nonHDL-C, ApoB level, ApoB A1 level and arteriosclerosis index (AI) were measured.The 269 patients with single-level LDH underwent surgery were enrolled as the disc herniation group and 269 patients who underwent surgical treatment for spine fracture(Pfirrmann Grading Systems of Grade I or II) during the same period were enrolled as the control group. The participants in the control group were selected randomly and matched for age (within 5 years) and sex. Results: In this analysis, we found that the level of TC, TG, LDL, nonHDL-C, APOB, and APOA1 in patients with LDH was significantly higher compared with that of the controls. The proportion of high TC, borderline high-total cholesterol, high LDL-C,high TG, borderline high LDL-C, high APO B, high AI and high ApoB/ApoA1 in the LDH group was significantly higher relative to that of the control group. The ratio of TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, nonHDL-C/HDL-C and ApoB/ApoA1 in the LDH group was significantly higher compared with that of the control group. Multivariate logistic regression analysis indicated that the levels of serum LDL-C, TC, TG, nonHDL-C, Apo B and AI were positively associated with the risk of LDH and were independent risk factors predicting LDH development. Conclusion: Overall, this study indicates that TC, TG, LDL-C, nonHDL-C, Apo B, and AI levels in may increase the risk of LDH.Dyslipidemia may be associated with cartilage endplate (CEP) degeneration and hence may be involved in the pathological process of intervertebral disc degeneration (IVDD). Moreover, dyslipidemia may be a useful predictor of IVDD.

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Obesity and Dyslipidemia in Chinese Adults: A Cross-Sectional Study in Shanghai, China

Cited by 29 publications

References 45 publications

Multi-trajectories of body mass index, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study

Multi-trajectories of body mass index, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study

Efficacy of traditional Chinese exercises in improving anthropometric and biochemical indicators in overweight and obese subjects: A systematic review and meta-analysis

Association of dyslipidemia with lumbar disc herniation: A case-control study

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