Obesity and iron metabolism

Żekanowska, Ewa; Boińska, Joanna; Giemza-Kucharska, Paulina; Kwapisz, Justyna

doi:10.5114/bta.2011.46528

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…Although obesity and iron deficiency usually represent opposite ends of the spectrum of malnutrition, some studies have shown a link between these two conditions. [10][11][12] Very few studies have reported on the relationship between transferrin saturation, MCV, MCH and anthropometric variables, with most referring only to haemoglobin. Some studies have reported a significant positive association between haemoglobin and overweight and obesity, central obesity 18 and body fat percentage 19 as well as serum ferritin concentrations and obesity.…”

Section: Discussionmentioning

confidence: 99%

“…9 Associations between obesity and iron deficiency have been described in the literature. [10][11][12] No studies have, however, investigated this relationship in women, particularly women of childbearing age, in South Africa. This study thus aimed to determine the prevalence of anaemia, iron deficiency and inflammation as well as body composition and associations between these variables as well as contraceptive use in women aged 25-49 years in three rural towns in the southern Free State.…”

Section: Introductionmentioning

confidence: 99%

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Obesity is associated with anaemia and iron deficiency indicators among women in the rural Free State, South Africa

Jordaan

Berg

Rooyen

et al. 2018

South African Journal of Clinical Nutrition

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Obesity and anaemia remain global public health problems, holding major consequences for human health. The objective was to determine body composition, prevalence of anaemia and iron deficiency, contraception use and associations between variables in rural women in the Free State, South Africa. Design: A cross-sectional study design was applied. Setting: The study was undertaken in rural Trompsburg, Philippolis and Springfontein. Subjects: A total of 134 HIV-uninfected non-pregnant females, aged between 25 and 49 years participated. Exposure and outcome measures: Data were collected on anthropometry, contraception use and biochemical markers of anaemia, iron deficiency and inflammation. Results: Median body mass index (BMI) (28.7 [24.2, 34.7] kg/m 2), waist circumference (90.8 [80.9, 103.0] cm) and body fat percentage (38.8 [34.3, 42.1] %) were classified as unhealthy. Only 2/134 had iron deficiency and 1/134 iron deficiency anaemia. Overall, 3.8% had low red cell folate levels. Almost half (45.0%) had elevated C-reactive protein (CRP) levels. More than half (54.1%) reported that they regularly menstruate and 71.6% currently or had previously used injectable contraceptives. Mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and transferrin saturation were significantly associated with BMI, waist circumference and body fat percentage. Conclusion: A predominant pattern of malnutrition, characterised by overweight and obesity, was prevalent. Risk for iron deficiency was associated with obesity. Prevalence of iron deficiency could be underestimated due to the large percentage with elevated CRP levels. Interventions should aim to improve the nutritional status of these women in order to reduce their risk for both chronic diseases and anaemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obesity is associated with anaemia and iron deficiency indicators among women in the rural Free State, South Africa

Jordaan

Berg

Rooyen

et al. 2018

South African Journal of Clinical Nutrition

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“…Theoretically, such an effect can be the consequence of iron sequestration in adipose-tissue macrophages induced by obesity (Yanoff et al , 2007; Zekanowska et al , 2011). …”

Section: Discussionmentioning

confidence: 99%

Influence of iron and copper consumption on weight gain and oxidative stress in adipose tissue of Wistar rats

Tinkov¹,

Ajsuvakova²,

Shehtman³

et al. 2012

Interdisciplinary Toxicology

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The aim of the present study was to assess the effect of iron and copper consumption on weight gain and development of oxidative stress in adipose tissue of rats. Control rats obtained pure drinking water. Iron-treated groups of animals obtained FeSO4•12H2O with drinking water in concentrations of 3 and 6 mg/l, while copper-treated rats obtained CuSO4 in concentrations of 4.88 and 9.76 mg/l. The animals of the 6th group received a mixture of FeSO4•12H2O and CuSO4 in the respective concentrations of 3 and 4.88 mg/l in drinking water. All animals received a standard chow. The final weight of rats from all the experimental groups, especially in those obtaining the combination of iron and cooper, exceeded the control values. Maximal weight of fat pads was observed in animals receiving drinking water with 3 mg/l FeSO4•12H2O, 4.88 and 9.76 mg/l CuSO4, and the mixture of FeSO4•12H2O and CuSO4. The maximal intensity of free radical processes, as estimated by the concentration of fluorescent modified amino acids and the intensity of chemiluminescence in adipose tissue homogenates, was observed in rats obtaining iron in the concentration of 3 mg/l in the drinking water.

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“…The interest in this association is still evident, as several studies were undertaken in developed countries between the years 2000 and 2011, which show that obesity is associated with iron deficiency [3][4][5][6]. Furthermore, there are a number of recent review publications on this subject [7][8][9].…”

Section: Introductionmentioning

confidence: 94%