2021
DOI: 10.1152/ajpgi.00199.2021
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Obesity and its effects on the esophageal mucosal barrier

Abstract: Obesity is associated with gastroesophageal reflux disease (GERD) and its complications including reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Traditionally, these associations have been attributed to the mechanical effect of abdominal fat in increasing intra-abdominal pressure, thereby promoting gastroesophageal reflux and causing disruption of anti-reflux mechanisms at the esophagogastric junction. However, recent studies suggest that visceral adipose tissue (VAT) produces numerous… Show more

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Cited by 23 publications
(11 citation statements)
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“…In other cases, it presented as ultrasound findings ( n = 1), threatened abortion ( n = 1), and epigastric pain with irradiation to the right hypochondrium ( n = 1). Obesity and MC with a displacement of intra-abdominal structures can exacerbate GER and urinary incontinence due to increased intra-abdominal pressure [14] , [15] , as in the present case. Obesity was presented in 17 % of the cases of MC in pregnancy and puerperium.…”
Section: Discussionsupporting
confidence: 59%
“…In other cases, it presented as ultrasound findings ( n = 1), threatened abortion ( n = 1), and epigastric pain with irradiation to the right hypochondrium ( n = 1). Obesity and MC with a displacement of intra-abdominal structures can exacerbate GER and urinary incontinence due to increased intra-abdominal pressure [14] , [15] , as in the present case. Obesity was presented in 17 % of the cases of MC in pregnancy and puerperium.…”
Section: Discussionsupporting
confidence: 59%
“…Therefore, the observed causal effect of obesity on PUD is likely to be independent of anti-inflammatory drug use or Helicobacter Pylori infection. Recent studies have linked obesity to mucosal dysfunction [ 33 , 34 ], which is one of the potential mechanisms associated with PUD [ 35 ]. In our study, we performed multivariable MR analyses to explore potential mediators.…”
Section: Discussionmentioning
confidence: 99%
“…Regarding esophageal disorders, it is important to note that the esophago-gastric junction (GC) fat pad, which envelopes the distal esophagus and shares its vascularity, warrants specific attention in this context [ 65 ]. In obesity, the EGJ fat pad is the location of VAT accumulation and source of proinflammatory and pro-cancerous substances, as Paris and colleagues pointed out in a recent paper [ 66 ].…”
Section: Epidemiologymentioning
confidence: 99%
“…It should be noted that visceral obesity is known to increase the local visceral fat tissue, known as the esophagogastric junction fat pad, which may be a source of pro-inflammatory adipokines reaching the mucosa of the distal part of the esophagus at a higher concentration than other tissues [ 66 ].…”
Section: Molecular Alterations In Experimental and Clinical Be And Ea...mentioning
confidence: 99%