Obesity and load‐induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma

Luna, Marysol; Guss, Jason D; Vasquez-Bolanos, Laura S; Alepuz, Adrian J; Dornevil, Sophie D.; Strong, Jasmin; Alabi, Denise; Shi, Qiaojuan; Pannellini, Tania; Otero, Miguel; Brito, Ilana L.; Meulen, Marjolein C. H. van der; Goldring, Steven R.; Hernandez, Christopher J.

doi:10.1002/jor.24799

Cited by 10 publications

(11 citation statements)

References 48 publications

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“…46,48 Figure 2B). The finding has been confirmed in subsequent studies 51 and early evidence suggests that factors produced by gut microbes may directly regulate bone tissue quality. 52 We recently found that the effect of the gut microbiome on bone tissue material properties is not limited to growing mice; alterations to the gut microbiome in aged mice (modified from 1 to 2 years of age) also lead to similar reductions in bone tissue mechanical properties.…”

Section: Can the Microbiome Help Prevent Periprosthetic Joint Infecmentioning

confidence: 63%

“…Guss and colleagues found that changes in the constituents of the gut microbiome in growing mice lead to impaired bone tissue strength at skeletal maturity—in the absence of noticeable changes in bone quantity 50 (Figure 2B). The finding has been confirmed in subsequent studies 51 and early evidence suggests that factors produced by gut microbes may directly regulate bone tissue quality 52 . We recently found that the effect of the gut microbiome on bone tissue material properties is not limited to growing mice; alterations to the gut microbiome in aged mice (modified from 1 to 2 years of age) also lead to similar reductions in bone tissue mechanical properties 53 .…”

Section: What Causes Poor Bone Tissue Quality?mentioning

confidence: 72%

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Musculoskeletal microbiology: The utility of the microbiome in orthopedics

Hernandez

2020

Journal Orthopaedic Research

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The past 15 years have witnessed a renaissance in the study of the microbes that colonize the human body. The vast majority of the human microbiome resides within the gut. Alterations to the gut microbiome have been associated with the pathogenesis and progression of wide‐ranging diseases throughout the body—including atherosclerosis, depression, and obesity. Our understanding of the effects of the gut microbiome on the musculoskeletal system remains in its infancy, but preclinical work has demonstrated an effect of the gut microbiome on the success of orthopedic surgical procedures, osteoporosis, osteoarthritis, and muscle mass. In this perspective I review preclinical findings demonstrating that an impaired presurgical gut microbiome can increase the likelihood of developing periprosthetic joint infection and how alterations in the gut microbiome can reduce bone strength by impairing bone tissue material properties. In addition to discussing these examples, I review the hypothesis that many chronic non‐communicable diseases have become more prevalent in modern industrialized societies as a result of changes in the composition of the gut microbiome resulting from changes in environment/lifestyle (diet, sanitation, antibiotic use). The most burdensome musculoskeletal disorders are chronic and non‐communicable and may therefore be related to generational shifts in the composition of the gut microbiome, a possibility I illustrate by reviewing changes in the prevalence of osteoarthritis over the last century. Microbiome‐based therapeutics are potentially innocuous, inexpensive, and have the potential to be effective with only occasional use, making them attractive for addressing the needs of chronic and/or slowly progressing musculoskeletal disorders.

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Section: Can the Microbiome Help Prevent Periprosthetic Joint Infecmentioning

confidence: 63%

Section: What Causes Poor Bone Tissue Quality?mentioning

confidence: 72%

Musculoskeletal microbiology: The utility of the microbiome in orthopedics

Hernandez

2020

Journal Orthopaedic Research

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“…The basic characteristics of participants in human studies was shown in Supplementary Table 2 . The animal studies included three non-intervention experiments ( 37 , 55 , 56 ), seven experiments about disturbing GMB to exacerbate OA ( 21 , 38 , 40 , 41 , 46 , 48 , 49 ), and 11 experiments about regulating GMB dysbiosis to alleviate OA ( 39 , 42 – 44 ; 45 , 47 , 50 – 54 ). The risk of bias was evaluated for each study ( Figures 2 , 3 ; Supplementary Table 3 , 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…They found that the Osteoarthritis Research Society International (OARSI) score of female and male mice was significantly decreased after antibiotic treatment, as well as the serum levels of IL-6, TNF-a, calcium ion, and MMP-13. Luna et al (49) performed cyclic loading to induce OA in mice and investigated the effects of HFD-induced obesity on cartilage damage and GMB. The study did not find an effect of obesity on cartilage damage, only a significant change in GMB composition was observed.…”

Section: Animal Studies: Intervention Studies About Gmb Dysbiosis Exa...mentioning

confidence: 99%

“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Liu

et al. 2023

Front. Immunol.

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ObjectivesThe aim of this systematic review was to summarize the available literature on gut microbiome (GMB) and osteoarthritis (OA), analyze the correlation between GMB and OA, and explore potential underlying mechanisms.MethodsA systematic search of the PubMed, Embase, Cochrane, and Web of Science with the keywords “Gut Microbiome” and “Osteoarthritis” was conducted to identify the human and animal studies exploring the association between GMB and OA. The retrieval time range was from the database inception to July 31, 2022. Studies reported the other arthritic diseases without OA, reviews, and studies focused on the microbiome in other parts of the body with OA, such as oral or skin, were excluded. The included studies were mainly reviewed for GMB composition, OA severity, inflammatory factors, and intestinal permeability.ResultsThere were 31 studies published met the inclusion criteria and were analyzed, including 10 human studies and 21 animal studies. Human and animal studies have reached a consistent conclusion that GMB dysbiosis could aggravate OA. In addition, several studies have found that alterations of GMB composition can increase intestinal permeability and serum levels of inflammatory factors, while regulating GMB can alleviate the changes. Owing to the susceptibility of GMB to internal and external environments, genetics, and geography, the included studies were not consistent in GMB composition analysis.ConclusionThere is a lack of high-quality studies evaluating the effects of GMB on OA. Available evidence indicated that GMB dysbiosis aggravated OA through activating the immune response and subsequent induction of inflammation. Future studies should focus on more prospective, cohort studies combined with multi-omics to further clarify the correlation.

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“…Most notable was the lowest diversity of gut microbiome in the antibiotic‐treated TLR5KO group, which had the lowest cartilage damage among the four groups, suggesting the role of the microbiome in mediating the cartilage damage. In another study examining the effects of antibiotic treatment of TLR5KO mice, gut microbiome richness was found to be reduced 46 . Severely obese wild‐type mice fed with HFD, TLR5KO mice, and antibiotic‐treated TLR5KO mice had distinct gut microbiome diversity from one another, with notable differences at the class level (Verrucomicrobiae, Gammaproteobacteria, Erysipelotrichi, Mollicutes, Actinobacteria, and Coriobacteria).…”

Section: Animal Studiesmentioning

confidence: 99%

Microbiome and osteoarthritis: New insights from animal and human studies

et al. 2021

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Osteoarthritis (OA) is a common cause of disability, especially among the elderly. With an ageing and increasingly obese population, OA will become more prevalent. Obesity and metabolic syndrome are risk factors for OA and have been implicated in its pathogenesis. The gut microbiome may shed light on this possible common pathogenesis. Recent animal and human studies have gained important insights into the relationship between OA, obesity, and the gut microbiome. Animal studies have demonstrated links between obesity and increased severity of OA and altered gut microbial DNA profile. Use of prebiotics and probiotics in animal trials provides proof‐of‐concept that interventional options to the gut microbiome can modulate the progression of OA favorably. Current evidence in human studies is limited. Shifts in gut microbial profile and reduced gut microbial diversity have been associated with people with OA, as well as blood and synovial fluid lipopolysaccharide endotoxemia. Linkages between microbiome dysbiosis and host responses may help in the understanding of OA pathogenesis and the discovery of therapeutic targets. This narrative review provides a summary of up‐to‐date animal and human studies on the gut microbiome and its link with OA.

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Obesity and load‐induced posttraumatic osteoarthritis in the absence of fracture or surgical trauma

Cited by 10 publications

References 48 publications

Musculoskeletal microbiology: The utility of the microbiome in orthopedics

Musculoskeletal microbiology: The utility of the microbiome in orthopedics

“Cross-talk” between gut microbiome dysbiosis and osteoarthritis progression: a systematic review

Microbiome and osteoarthritis: New insights from animal and human studies

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