Obesity and Metabolic Abnormalities in Offspring of Subjects with Diabetes Mellitus

Praveen, Edavan Pulikkanath; Kulshreshtha, Bindu; Khurana, Madan Lal; Sahoo, Jaya Prakash; Gupta, Nidhi; Kumar, Guresh; Dwivedi, Sada Nand; Ammini, Ariachery C.

doi:10.1089/dia.2009.0163

Cited by 15 publications

(12 citation statements)

References 50 publications

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“…7,8 Studies carried out in different populations and ethnic groups reported high prevalence of obesity and metabolic abnormalities in offspring of diabetic parents, predisposing them at the risk of developing diabetes. 11,22,21 In our study 19% of the subjects (age 15 -25 years) with FHD are obese which is in consistent with the study reported recently from India but lower when compared with 26,27 studies from Eastern Europe and Middle East. When parental consanguinity was also considered along with FHD the prevalence of obesity increased to 24% which showed the effect of parental consanguinity on metabolic disturbances in the offspring.…”

Section: Discussionsupporting

confidence: 92%

“…7,8 Evidence is available suggesting disturbances of carbohydrate and lipid metabolism in individuals with a history of T2DM in first degree relatives. [9][10][11][12] Previous studies reported higher fasting plasma glucose (FPG) in non-diabetic males with a FHD as compared to those with no FHD. 13,14 A study reported that Asian Indian adolescents with both diabetic parents had high FPG was as compared to one diabetic parent.…”

Section: Original Articlementioning

confidence: 99%

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Family History of Diabetes and Parental Consanguinity: Important Risk for Impaired Fasting Glucose in South East Asians

Shahid¹,

Saeed²,

Rana³

et al. 2012

West Indian Med J

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Objective: Offspring of type 2 diabetics have increased risk of metabolic disturbances. The aim of the study was to access the potential effect of family history of type 2 diabetes (FHD) and parental consanguinity on fasting plasma glucose (FPG) levels. Design: Non diabetic offspring of one or both parents with type 2 diabetes and healthy controls of comparable age, without a FHD were the subjects of this study. FHD was defined by the presence of type 2 diabetes in one or both parents of the subject. Consanguinity was defined as history of marriage with first cousin. FPG levels were determined in cases and controls.

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Section: Discussionsupporting

confidence: 92%

Section: Original Articlementioning

confidence: 99%

Family History of Diabetes and Parental Consanguinity: Important Risk for Impaired Fasting Glucose in South East Asians

Shahid¹,

Saeed²,

Rana³

et al. 2012

West Indian Med J

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“…Our sampling frame was ‘Offspring of individuals with diabetes study’ database (Praveen et al ., ). There were 358 subjects who had family members (parent or grandparent) with type 2 diabetes mellitus (T2DM) and 287 subjects who did not have family history of T2DM, recruited for the study.…”

Section: Methodsmentioning

confidence: 97%

Plasma testosterone in adult normoglycaemic men: impact of hyperinsulinaemia

et al. 2012

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This study analysed the relationship of plasma testosterone with β-cell secretion, insulin sensitivity and other pituitary-target gland hormones in normoglycaemic adult men. The sample frame was the 'Offspring of individuals with diabetes study' database. A total of 358 offspring of individuals with type-2 diabetes (T2DM) and 287 individuals without known family history of T2DM were recruited for the study. Normoglycaemic men aged ≥18 years (maximum 55) were selected for this analysis. All participants underwent 75 g oral glucose tolerance test (OGTT); blood samples were collected at 0, 30, 60 and 120 min for plasma insulin and C-peptide. Total testosterone, cortisol, adrenocorticotropic hormone, thyroid stimulating hormone and thyroxine (T4) were measured in the fasting sample. A total of 164 men (age 28 ± 7.7 years) were included in analysis. Testosterone correlated negatively with BMI, waist to hip ratio (WHR), area under curve (AUC) of C-peptide and insulin (during OGTT) and was positively correlated with insulin sensitivity (r ~ 0.4). Cortisol and T4 positively correlated (weak) with testosterone (r ~ 0.2). In multivariate analysis, AUC C-peptide, BMI, WHR (negatively) and cortisol (positively) were related to testosterone. Concluding, testosterone correlated negatively with BMI and β-cell secretion. There was a positive association of testosterone with insulin sensitivity, cortisol and T4.

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“…Our sampling frame was the “Offspring of individuals with diabetes study” database 12. There were 358 offspring of individuals with type 2 diabetes mellitus (T2DM) and 287 controls (individuals who did not have a family history of T2DM) recruited for the study.…”

Section: Methodsmentioning

confidence: 99%

Morning cortisol is lower in obese individuals with normal glucose tolerance

Praveen¹,

Sahoo²,

Kulshreshtha³

et al. 2011

DMSO

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BackgroundThere is no consensus on the role of cortisol in the pathogenesis of obesity and metabolic syndrome (MS). This cross-sectional study aimed to analyze the relationship of morning plasma cortisol and adrenocorticotropic hormone (ACTH) levels with body mass index (BMI) and glucose tolerance.Subjects and methodsThe sample frame was the “Offspring of individuals with diabetes study” database. A total of 358 offspring of individuals with type 2 diabetes mellitus (T2DM) and 287 individuals without a known family history of T2DM were recruited for the study. Subjects who were ≥10 years of age were selected from the database for analysis. Subjects with T2DM were excluded. All participants underwent a 75 g oral glucose tolerance test (OGTT), and blood samples were collected at 0, 30, 60, and 120 minutes for glucose, insulin and C-peptide. Plasma cortisol, ACTH, and lipid profile were estimated from the fasting sample.ResultsFour hundred and ninety-five participants (305 males [62%] and 190 females [38%]) were included in the analysis. ACTH and cortisol levels were higher in normal-weight subjects than in overweight/obese subjects. Both ACTH and cortisol increased as fasting plasma glucose increased. Cortisol levels were significantly lower in offspring of T2DM subjects with MS than in offspring of T2DM subjects without MS. When adjusted for BMI, the significance was marginal. In males, cortisol levels were negatively correlated with early insulin secretion during OGTT (insulinogenic index [0–30]) and positively with waist circumference and serum high-density lipoprotein cholesterol. In females, fasting glucose and systolic blood pressure were significantly and positively correlated.ConclusionBody weight was correlated negatively with morning plasma cortisol and ACTH, whereas fasting glucose was correlated positively.

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Obesity and Metabolic Abnormalities in Offspring of Subjects with Diabetes Mellitus

Abstract: Children from families with type 2 diabetes are at increased risk for obesity. Risk increases by fivefold when both parents have diabetes.

Cited by 15 publications

References 50 publications

Family History of Diabetes and Parental Consanguinity: Important Risk for Impaired Fasting Glucose in South East Asians

Family History of Diabetes and Parental Consanguinity: Important Risk for Impaired Fasting Glucose in South East Asians

Plasma testosterone in adult normoglycaemic men: impact of hyperinsulinaemia

Morning cortisol is lower in obese individuals with normal glucose tolerance

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