Obesity and metabolic syndrome in COPD: Is exercise the answer?

James, Ben; Jones, Amy; Trethewey, Ruth; Evans, Rachael A.

doi:10.1177/1479972317736294

Cited by 33 publications

(27 citation statements)

References 79 publications

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“…13 Therefore, it is believed that obesity in patients with COPD should be treated with weight loss through exercise, which is conducive to improved lung function and reduced complications. 14 However, there have been studies that suggested that "overweight" and obesity could prolong survival in patients with chronic heart or kidney diseases. 15,16 This phenomenon is referred to as the "obesity paradox".…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of Body Mass Index on Lung Function in Chinese Patients with Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study</p>

Zhu

Zhao

et al. 2020

COPD

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The aim of this study was to explain "obesity paradox" in chronic obstructive pulmonary disease (COPD) by evaluating the effect of body mass index (BMI) on lung function in Chinese patients with COPD. Methods: A total of 1644 patients diagnosed with COPD were recruited from four Chinese tertiary hospitals and were divided into four groups including underweight, normal weight, overweight and obese according to BMI classification standard. The medical data of these patients were collected and used for the multiple linear regression analyses. Results: After adjustment for age, sex, educational level, economic status, smoking status, alcohol consumption, duration of COPD history, events of acute exacerbation in previous year, hypertension, diabetes mellitus, cardiovascular disease, cerebrovascular disease and osteoporosis, BMI had a curvilinear correlation with the forced expiratory volume in the first second (FEV 1) in patients with Global Initiative for Obstructive Lung Disease (GOLD) 1-2 grade (first-order coefficient β, 0.09; 95% CI, 0.03-0.16; second-order coefficient β, −0.002; 95% CI, −0.003-0.001; P<0.01). However, BMI had a positive correlation with FEV 1 in patients with GOLD 3-4 grade (β, 0.01; 95% CI, 0.008-0.017; P<0.01) when BMI was used as a quantitative variable. When BMI was used as a qualitative variable, only FEV 1 in overweight group with GOLD 1-2 grade was significantly higher than that of normal weight group (P<0.01). Interestingly, both overweight and obese groups had higher FEV 1 in GOLD 3-4 grade compared with normal weight group (β, 0.06; 95% CI, 0.02-0.11; β, 0.11; 95% CI, 0.04-0.18; P<0.01). The effect of BMI on predicted percentage of FEV 1 (FEV 1 %) was similar to that of FEV 1 in different GOLD grades. Conclusion: Obesity only had a protective effect on lung function in COPD patients with GOLD 3-4 grade rather than GOLD 1-2 grade.

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Section: Introductionmentioning

confidence: 99%

<p>Effect of Body Mass Index on Lung Function in Chinese Patients with Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study</p>

Zhu

Zhao

et al. 2020

COPD

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“…Incidence of comorbidities in diabetes patients were common, at least half of these patients had three or more comorbid chronic diseases (James at al., 2018). Presence of comorbidities complicate the management of the disease and make the management of the disease costlier for the healthcare systems.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Inhaled Corticosteroids Used for the Treatment of Asthma on the Management of Diabetes Mellitus

2020

JHMN

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In this study, it is aimed to investigate the impact of inhaled corticosteroids on the management of diabetes in diabetic patients diagnosed with asthma. This is a retrospective case control study. 188 patients diagnosed with diabetes mellitus and 88 diabetes mellitus patients diagnosed with asthma -276 patients in total -were enrolled in the study. Patients using systemic steroids for any reason, patients diagnosed with diabetes, who do not take medication regularly, patients with diabetic ketoacidosis and patients, who had an asthma episode requiring the use of oral steroids in the past year were excluded from the study. A total of 276 patients; 88 (31.9%) male and 188 (68.1%) female were enrolled in the study with the average age being 58.9±9.4. 68.1% (188) of the patients enrolled in the study were diagnosed with diabetes mellitus and 31.9% (88) were diabetes mellitus patients diagnosed with asthma. The comparison between the group not diagnosed with asthma and the group diagnosed with asthma, blood glucose (p<0.007) levels and incidence of neuropathy (p<0.002) were significantly higher in patients diagnosed with asthma and incidence of nephropathy (p<0.024) was significantly higher in patients not diagnosed with asthma. In our study, no statistically significant differences were observed between the two groups with regard to age, haemoglobin levels and glycated haemoglobin levels. In conclusion, the use of low-medium dose inhaled corticosteroids in diabetes mellitus patients diagnosed with asthma does not have an impact on glycated haemoglobin levels but with regard to diabetes-related complications, it may cause an increase in blood glucose levels and neuropathy risk.

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“…Comorbid obesity or metabolic syndrome are common in COPD 66 . A link between metabolic syndrome and lung disease has been observed in several cross-sectional and longitudinal studies [67][68][69][70] .…”

Section: Copd As Comorbidity Of Other Frequent Chronic Diseasesmentioning

confidence: 99%