Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi

Modulation of Inflammatory and Hemostatic Markers in Obstructive Sleep Apnea Patients Treated with Mandibular Advancement Splints: A Parallel, Controlled Trial

“…Indeed, it has been suggested that elevated CRP in OSA may be related to obesity and not OSA itself. 7,8 In mild-to-moderate OSA subjects, we have demonstrated elevated IL-1β, a marker of systemic inflammation and activated innate immunity, 23 as well as elevated fibrinogen, which is in line with most published reports. 4 A marked drop in serum IL-1β might indirectly reflect an attenuated systemic inflammatory state during MAS therapy, which agrees with the study by Tomiyama et al, 10 who among other parameters measured IL-1β on CPAP treatment.…”

“…6 Data on alterations in plasma levels of C-reactive protein (CRP), [7][8][9] interleukin-6 (IL-6), 10 interleukin-1β (IL-1β), 11 and interleukin-10 (IL-10) 11 in OSA are inconsistent. The gold standard of treatment of severe OSA is the use of continuous positive airway pressure (CPAP).…”

Serum Inflammatory Markers in Obstructive Sleep Apnea: A Meta-Analysis

“…They have concluded that obesity and not OSA was associated with elevated serum levels of high sensitivity CRP (hs-CRP), and there was no independent Figure 8-ICAM standardized mean difference, OSA versus controls correlation found between severity of OSA and hs-CRP. 73 This meta-regression analysis showed modest but significant effect of BMI on inflammatory markers. In contrast, Guilleminault et al 49 found that mean serum level of CRP was normal in obstructive sleep apnea syndrome (OSAS), upper airway resistance syndrome (UARS), and normal controls.…”

“…In a cross-sectional study by Sharma et al 73 to determine whether obesity or OSA is responsible for increased serum levels of CRP in patients with sleep disordered breathing, they found that CRP levels were higher in obese non apneic patients when compared to apneic patients. They have concluded that obesity and not OSA was associated with elevated serum levels of high sensitivity CRP (hs-CRP), and there was no independent Figure 8-ICAM standardized mean difference, OSA versus controls correlation found between severity of OSA and hs-CRP.…”

Obstructive sleep apnea syndrome and cardiovascular disease: The influence of C-reactive protein

“…One should keep in mind that obesity is prevalent in patients with OSAS, and it has been shown that elevated CRP levels are significantly and independently correlated to high BMI [45] . Similarly, other investigators found that CRP levels in OSAS strongly correlate to obesity and not to OSAS severity [42,46,47] . Therefore, based on these studies as nonobese OSAS patients don't demonstrate statistically increased levels of CRP, any CRP elevation noted in obese OSAS patients may reflect chronic inflammation attributable to obesity and not to chronic hypoxia due to OSAS.…”