Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up

Grotle, Margreth; Hagen, Kåre Birger; Natvig, Bent; Dahl, Fredrik A.; Kvien, Tore K

doi:10.1186/1471-2474-9-132

Cited by 525 publications

(382 citation statements)

References 24 publications

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“…In addition, their results differed from our with regard to the high prevalence of hip pain (54.5%) compared with that observed in our population (21.95%). This is in accordance with a study that did not find any association between BMI and the occurrence of hip osteoarthritis (20).…”

Section: Discussionsupporting

confidence: 81%

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Prevalence of musculoskeletal symptoms in obese patients candidates for bariatric surgery and its impact on health related quality of life

Calenzani

Santos

Wittmer

et al. 2017

Arch. Endocrinol. Metab.

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Objective: This study was designed to identify the major musculoskeletal symptoms of individuals with obesity, to assess their health-related quality of life, and to evaluate the correlation between the musculoskeletal symptoms and the individuals' health-related quality of life. Materials and methods: Cross-sectional study. Instruments used: "Nordic Musculoskeletal Questionnaire" and "The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36)" . Results: In total, 41 subjects were evaluated, of which 90.15% were female. The mean age of the subjects was 40.78 ± 9.85 years and their mean body-mass index was 46.87 ± 8.08. All subjects reported musculoskeletal pain in at least one anatomical region and 80.49% had pain in three or more regions. The activity limitations due to pain were reported by 75.61% of them. The most affected regions by pain were the ankles and/or feet, lower back, knees and wrists/hands/fingers. The most associated regions with activity limitations due to pain were the ankles and/or feet, knees and lower back. The presence of pain showed a negative correlation with the domains physical functioning (PF), role-physical (RP) and body pain (BP). The activity limitations showed a negative correlation with the domains PF, BP, social functioning (SF) and role-emotional (RE). Conclusion: Our data showed a high prevalence of musculoskeletal pain and limitation in activities due to pain in obese subjects. The musculoskeletal symptoms had negative correlations with physical and mental components of the health-related quality of life, highlighting the importance of ensuring that patients with obesity have access to interdisciplinary care, for the prevention and rehabilitation of musculoskeletal disorders. Arch Endocrinol Metab. 2017;61(3):319-25.

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Section: Discussionsupporting

confidence: 81%

“…It has been demonstrated that weight gain is associated with adverse effects on the knees, such as pain, stiffness and functional changes (22). Additionally, it has reported that BMI > 30 kg/m² is an important risk factor for the incidence of knee osteoarthritis (20).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of musculoskeletal symptoms in obese patients candidates for bariatric surgery and its impact on health related quality of life

Calenzani

Santos

Wittmer

et al. 2017

Arch. Endocrinol. Metab.

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“…Além disso, estudos mostram que a maior prevalência de sobrepeso e obesidade resultam em alta incidência da OA de joelho nessa população 12,13,17 . Justifica-se ainda a amostra feminina do presente estudo pelo fato de os sintomas da OA ocorrerem antecipadamente em mulheres 17 . Ismail et al 18 , examinando mais de 200 pacientes com OA de joelhos, encontraram que mais de 90% eram obesos ou com sobrepeso, sendo maior a prevalência no sexo feminino, em uma relação de 2,4:1 para o sexo masculino.…”

Section: Discussão E Conclusãounclassified

Avaliação antropométrica e do ângulo quadricipital na osteoartrite de joelho em mulheres obesas

Chacur

Silva²,

Luz³

et al. 2010

Fisioter. Pesqui.

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RESUMO: A osteoartrite (OA) é uma doença articular degenerativa, caracterizada por processo inflamatório, dor e deformidades; um de seus fatores preditivos é a obesidade. O objetivo deste estudo foi verificar possíveis correlações entre medidas antropométricas, o ângulo quadricipital (Q) e a osteoartrite de joelho. A amostra foi composta por 50 voluntárias obesas (30 com OA de joelho e 20 sem OA), com idade entre 40 e 60 anos. Foram mensurados, além do IMC (índice de massa corporal), circunferência abdominal (CA), perímetros de cintura e quadril para cálculo da relação cintura-quadril e o ângulo Q; a osteoartrite foi diagnosticada clinicamente e por meio de radiografia da articulação do joelho. Foram encontradas correlações positivas fracas entre IMC e ângulo Q e entre tempo de obesidade e grau de degeneração articular. A CA apresentou correlação positiva fraca com o grau de degeneração articular e o de gravidade da OA. O cálculo da razão de chance (OR) indica que as voluntárias com IMC>34 kg/m 2 e CA>110 cm tiveram 3,7 e 7 vezes, respectivamente, mais chance de apresentarem OA. A obesidade central, seu grau e duração possivelmente contribuem para a incidência da OA de joelhos em mulheres obesas. A circunferência abdominal foi a medida que melhor se correlacionou com a presença e grau de OA em obesas, o que aponta para a relevância de sua mensuração na avaliação clínica. DESCRITORES: Antropometria; Mulheres; Obesidade; Osteoartrite do joelho ABSTRACT: Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory process, pain, and deformity; one of its main predictive factors is obesity. The aim of this study was to search for possible correlations between anthropometric measures, the Q angle and knee osteoarthritis. A sample of 50 obese women (30 with knee osteoarthritis and 20 with no joint disease), aged between 40 to 60 years, were assessed as to BMI (body mass index), abdominal circumference (AC), waist and hip perimeters (so as to calculate waist-hip ratio), and the Q angle; osteoarthritis was diagnosed by clinical exam and knee joint radiography. Results showed a positive, poor correlation between BMI and Q angle, as well as between time of obesity onset and degree of joint degeneration. AC was found to positively, though weakly, correlate with the degree of joint degeneration and of OA severity. Adjusted odds ratio for OA showed that women with BMI>34 kg/m 2 and AC>110 cm were respectively 3.7 and 7 times more likely to develop OA. The degree and duration of central obesity possibly contribute to incidence of knee OA in obese women. Abdominal circumference was the measure that most correlated with the degree of joint degeneration and of OA severity, which suggests it should be used in clinical evaluation.

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“…This is further supported by studies that find increased plantar pressure in the foot as obesity increases (18) and a reduction of pain with weight loss (19). The association of obesity with painful, nonweightbearing joints, such as the hand (20), is not in keeping with the mechanical overload pathway and suggests that the metabolic effect of obesity may be an important consideration systemically. Despite investigations into the significance of adipokines in other regions of the body (21,22), their association with foot pain has not been formally investigated.…”

Section: Introductionmentioning

confidence: 87%

Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort

Walsh

Gill

Evans

et al. 2016

Arthritis Care & Research

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Objective. To determine, first, if fat mass index (FMI) or fat-free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin-6 (IL-6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain. Methods. A subset of participants ages ‡50 years (n 5 1,462) from the North West Adelaide Health Study were used for this study. Participants from this community cohort were asked in stage 2 (2004)(2005)(2006) and stage 3 (2008-2010) if they had foot pain, aching, or stiffness. In stage 2, serum adipokines and anthropometry were measured, while body composition was analyzed with dual x-ray absorptiometry. These variables, along with comorbidities and social history, were used in logistic regression analyses to determine if FMI, FFMI, and serum adipokines were associated with foot pain. Results. Prevalent foot pain was present in 20.2% of participants, and future foot pain in 36.4%. Following multivariate modeling, the odds of having pain at stage 2 increased by 8% for each FMI unit (odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.04-1.12), while the odds of having pain at stage 3 increased by 6% for each FMI unit at stage 2 (OR 1.06, 95% CI 1.02-1.11). TNF level, IL-6 level, and FFMI were not associated with pain. Conclusion. Increased FMI, but not body mass index, FFMI, or TNF or IL-6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation.

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Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up

Cited by 525 publications

References 24 publications

Prevalence of musculoskeletal symptoms in obese patients candidates for bariatric surgery and its impact on health related quality of life

Prevalence of musculoskeletal symptoms in obese patients candidates for bariatric surgery and its impact on health related quality of life

Avaliação antropométrica e do ângulo quadricipital na osteoartrite de joelho em mulheres obesas

Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort

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