Obesity and risk of incident psoriatic arthritis in US women

Abstract

Objectives Both overall and central obesity has been associated with risk of psoriasis from prospective study. Data on the association between obesity and psoriatic arthritis (PsA) have been very sparse and no evidence on obesity measures and risk of incident PsA is available now. We aimed to evaluate the association between obesity and risk of incident PsA in a large cohort of women. Methods A total of 89,049 participants were included from the Nurses Health Study II over a 14-year time period (1991–2005). Information on BMI, weight change, and measures of central obesity (waist circumference, hip circumference, and waist-hip ratio) was collected during the follow-up. Incidence of clinician-diagnosed PsA was ascertained and confirmed by supplementary questionnaires. Results We identified 146 incident PsA cases during 1,231,693 person-years’ follow-up. Among total participants, BMI was monotonically associated with an increased risk of incident PsA. Compared with BMI less than 25.0, the relative risk (RR) was 1.83 for BMI 25.0 through 29.9 (95% confidence interval (CI): 1.15–2.89), 3.12 for BMI 30.0 through 34.9 (95% CI: 1.90–5.11), and 6.46 for BMI > 35.0 (95% CI: 4.11–10.16). There was a graded positive association between weight change from age 18, measures of central obesity, and risk of PsA (P for trend <0.001). The analysis among participants developing psoriasis during follow-up revealed a similar association (P for trend <0.01), indicating an increased risk of PsA associated with obesity among psoriatics. Conclusion In this study we provide further evidence linking obesity with risk of incident PsA among U.S. women.

Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity

“…In other words, whether obesity directly increases the risk of developing of PsA among patients with psoriasis or whether arthritis leads to lower levels of physical activity causing weight gain. Recent results from a prospective cohort study among women support the paradigm that obesity is a risk factor for the development of PsA among patients with psoriasis 37. Additional prospective studies are needed to investigate this link.…”

Current Concepts in Psoriatic Arthritis: Pathogenesis and Management

“…Epidemiologic studies have shown a positive correlation between body mass index and the risk of incident PsA in psoriasis populations (15,16). In addition to being a risk factor for PsA, obesity may also adversely impact the efficacy of tumour necrosis factor (TNF) inhibitors in decreasing disease activity in PsA, although the evidence is inconclusive (17,18).…”

Psoriasin: A Novel Marker Linked Obesity with Psoriasis

“…Both overall and central obesity have been associated with the risk of psoriasis in a prospective study. The study provided evidence linking obesity with the risk of incident PsA among US women [8]. Patients with moderate-to-severe psoriasis have a significantly increased risk of cardiovascular disease and cardiovascular risk factors such as obesity, diabetes mellitus, the metabolic syndrome and smoking compared to the general population.…”