Obesity and the levels of liver enzymes (ALT, AST &amp; GGT) in East Medinipur, India

Das, Ajay; Chandra, Prasanna; Gupta, Akash; Ahmad, Naved

doi:10.3126/ajms.v6i1.10147

Cited by 11 publications

(8 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, no effect was observed for decreased BMI on serum ALT and AST levels 54 . In another study, ALT, AST and GGT levels were found to be higher in obese individuals but these liver enzymes did not show any significant correlation with obesity 55 . These inconsistent findings may reflect the differences of population groups between the studies.…”

Section: Discussionmentioning

confidence: 85%

Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population

Ali

Sumon

Fariha

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Obesity is a global health concern because of its increasing trend both in developed and developing countries. A limited number of studies have evaluated the association of liver enzymes with both general and abdominal obesity in the general population; data for the Bangladeshi population are not available yet. This study aimed to assess the relationship of serum liver enzymes activity with both general and abdominal obesity in Bangladeshi adults. In total, 540 blood samples were obtained from the participants (388 males and 152 females) and analyzed for serum levels of ALT, AST, GGT, and ALP using standard methods. General obesity was defined as body mass index (BMI) ≥ 27.5 kg/m2 and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm in males and ≥ 80 cm in females. The relationship between liver enzymes and obesity was evaluated by multivariate logistic regression models. Overall, 58% of participants in the general obesity group and 55% of the participants in the abdominal obesity group had at least one or more elevated levels of liver enzymes. The prevalence of elevated liver enzymes was significantly higher in the obesity group compared to the normal BMI and WC groups (p < 0.05 for all cases). The mean level of serum ALT, AST and GGT were significantly higher in the obesity group than the normal BMI group (p < 0.05). In the WC groups, mean AST and GGT were significantly higher in the obesity group compared to the normal group (p < 0.05). In regression analysis, serum levels of ALT showed an independent and significant association with general obesity, whereas, serum GGT showed a significant association with both general and abdominal obesity. In conclusion, a high prevalence of elevated liver enzymes was observed among participants included in the present study. Of the four enzymes, serum GGT was independently associated with both general and abdominal obesity. Further studies are required to understand the complex relationship between liver enzymes and obesity in the general population.

show abstract

Section: Discussionmentioning

confidence: 85%

Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population

Ali

Sumon

Fariha

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Serum GGT showed a significant association with both general and abdominal obesity 34 . Das et al found that ALT, AST and GGT levels were higher in individuals with obesity, but no direct association was found between these liver enzymes with obesity 35 …”

Section: Discussionmentioning

confidence: 98%

The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

Jalili

Poorahmadi

Ardekanizadeh

et al. 2022

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

Background: Obesity-induced inflammation may independently disturb the function of critical organs such as liver. This study aimed to investigate the association of obesity with serum levels of biomarkers of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) in adult women. Methods:This cross-sectional study was carried out on 360 adult women in the summer of 2020 in Tehran, Iran. The participants were categorized into two groups based on their body mass index (BMI≤29.9 and BMI > 30). The serum levels of ALT, AST, ALP How to cite this article: Jalili V, Poorahmadi Z, Hasanpour Ardekanizadeh N, et al. The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma-glutamyl transferase in adult women.

show abstract

“…Free radicals will interfere with the integrity of the hepatocyte membrane, thus eliminating various enzymes from hepatocytes (Ryeo-Eun et al, 2016). Obesity can interfere with liver function due to NAFLD, which causes damage to liver cells, which then results in increased activity of the enzymes AST, ALT, and ALP (Das et al, 2015).…”

Section: Effect Of Scenedesmus Dimorphus On Liver Functionmentioning

confidence: 99%

The nutraceutical effect of Scenedesmus dimorphus for obesity and nonalcoholic fatty liver disease–linked metabolic syndrome

2020

J app pharm sci

View full text Add to dashboard Cite

Obesity is a major cause of nonalcoholic fatty liver disease (NAFLD), which is identified as a characteristic related to metabolic syndrome. This study focuses on the benefits of Scenadesmus dimorphus as a nutraceutical to overcome NAFLD-linked metabolic syndrome caused by obesity. The research used 30 mice (Mus musculus) divided into six groups: normal control, obesity control (OC), and drug control (Orlistat) and S. dimorphus administrated orally for 21 days in obese mice with NAFLD-linked metabolic syndrome with doses of 5 mg/20 g body weight (BW), 10 mg/20 g BW, and 15 mg/20 g BW. The administration of a high-fat diet can cause obese mice to suffer from NAFLD, resulting in an increase in liver enzymes and changes in lipid metabolism. Administration of S. dimorphus at 15 mg/20 g BW decreases the activity of liver enzymes and improves liver function. The statistics test showed significant differences (p < 0.05 analysis of variance) to decrease the liver enzyme activity of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase compared to OCs. Administration of S. dimorphus resulting in metabolism changes showed a significant (at p < 0.05) decrease in total cholesterol, triglycerides, and low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol. Microalgae S. dimorphus is beneficial as a nutraceutical to manage obesity and reverse NAFLD-linked metabolic syndrome in obese mice.

show abstract

Obesity and the levels of liver enzymes (ALT, AST & GGT) in East Medinipur, India

Cited by 11 publications

References 11 publications

Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population

Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population

The association between obesity with serum levels of liver enzymes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma‐glutamyl transferase in adult women

The nutraceutical effect of Scenedesmus dimorphus for obesity and nonalcoholic fatty liver disease–linked metabolic syndrome

Contact Info

Product

Resources

About