Obesity and the Use of Antibiotics and Probiotics in Rats

Fiol, Fernando de Sá Del; Ferreira, Alessandra Cristina Marciano Tardelli; Marciano, Jorge José; Marques, Maria Claudia; Santana, Luciane Lopes

doi:10.1159/000371737

Cited by 19 publications

(10 citation statements)

References 48 publications

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“…Similar to the previous study (de Sá Del Fiol et al, 2014), no difference in rodent weight gain nor the occurrence of adverse clinical signs in antibiotic-fed rats was observed in this work. In addition, our result was in accordance with the previous finding showing that the administration of an antibiotic cocktail (ampicillin, vancomycin, neomycin, metronidazol and amphotericin-B) to rats led to a minimum of 100-fold decrease in cultivable microbes (Reikvam et al, 2011).…”

Section: Probiotic Mixture Did Not Alter Rat Body Weightsupporting

confidence: 91%

Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model

Luang-In¹,

Katisart²,

Konsue³

et al. 2020

Food Sci Anim Resour

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This work aimed to investigate the psychobiotic effects of six bacterial strains on the mind and behavior of male Wistar rats. The probiotic (PRO) group (n = 7) were rats pre-treated with antibiotics for 7 days followed by 14-day probiotic administration, antibiotics (ANT) group (n = 7) were rats treated with antibiotics for 21 days without probiotics. The control (CON) group (n = 7) were rats that received sham treatment for 21 days. The six bacterial strains with probiotic properties were mostly isolated from Thai fermented foods; Pedicoccus pentosaceus WS11, Lactobacillus plantarum SK321, L. fermentum SK324, L. brevis TRBC 3003, Bifidobacterium adolescentis TBRC 7154 and Lactococcus lactis subsp. lactis TBRC 375. The probiotics were freeze-dried into powder (6×10 9 CFU/5 g) and administered to the PRO group via oral gavage. Behavioral tests were performed. The PRO group displayed significantly reduced anxiety level and increased locomotor function using a marble burying test and open field test, respectively and significantly improved short-term memory performance using a novel object recognition test. Antibiotics significantly reduced microbial counts in rat feces in the ANT group by 100 fold compared to the PRO group. Probiotics significantly enhanced antioxidant enzymatic and nonenzymatic defenses in rat brains as assessed using catalase activity and ferric reducing antioxidant power assay, respectively. Probiotics also showed neuroprotective effects with less pyknotic cells and lower frequency of vacuolization in cerebral cortex. This multi-strain probiotic formulation from Thai fermented foods may offer a potential to develop psychobiotic-rich functional foods to modulate human mind and behaviors.

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Section: Probiotic Mixture Did Not Alter Rat Body Weightsupporting

confidence: 91%

Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model

Luang-In¹,

Katisart²,

Konsue³

et al. 2020

Food Sci Anim Resour

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“…The antibiotic serves only to alter it (Backhed et al, 2004; Turnbaugh et al, 2006; Goodman et al, 2011; Kimura et al, 2013; Cox et al, 2014; Gerard, 2016). Studies carried out using regular animals (non-germ-free) that received antibiotics point to the same direction, increasing the weight of the animals due to changes in their gut microbiota (Cho et al, 2012; de Sa Del Fiol et al, 2014; Khan et al, 2016; Marciano et al, 2017).…”

Section: Antibiotics and Obesitymentioning

confidence: 98%

Obesity: A New Adverse Effect of Antibiotics?

et al. 2018

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Since the introduction of antibiotics, they have been used freely, with their prescription occurring almost always when they were not necessary. The other major form of contact between humans and antibiotics, now unintentionally, is with the large amount of these drugs in the environment and in our food. The relationship between antibiotic use and the development of obesity has become increasingly evident and apparent in humans, with some authors clearly establishing the relationship between the large-scale use of antibiotics in the past 70 years and the “epidemic” of obesity that has occurred in parallel, almost as an adverse epidemiological effect. In the research effort entertained herein, a correlation between the use and abuse of antibiotics and the onset of obesity was investigated.

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“…Research shows the involvement of gut bacteria, and possibly their metabolites, in energy homeostasis. For example, antibiotic treatment in rats promotes increase in body mass index [20]. Furthermore, several antibiotics have been used for decades to increase food intake and weight gain in poultry/broiler chicks [21].…”

Section: Introductionmentioning

confidence: 99%

Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats

et al. 2019

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Recent evidence suggests that tryptophan, an essential amino acid, may exert biological effects by means of tryptophan-derived gut bacteria products. We evaluated the potential contribution of tryptophan-derived bacterial metabolites to body weight gain. The study comprised three experimental series performed on separate groups of male, Sprague-Dawley rats: (i) rats on standard laboratory diet treated with water solution of neomycin, an antibiotic, or tap water (controls-1); (ii) rats on standard diet (controls-2) or tryptophan-high (TH) or tryptophan-free (TF) diet; and (iii) rats treated with indole-3-propionic acid (I3P), a bacterial metabolite of tryptophan, or a vehicle (controls-3). (i) Rats treated with neomycin showed a significantly higher weight gain but lower stool and blood concentration of I3P than controls-1. (ii) The TH group showed significantly smaller increases in body weight but higher stool and plasma concentration of I3P than controls-2. In contrast, the TF group showed a decrease in body weight, decreased total serum protein and a significant increase in urine output. (iii) Rats treated with I3P showed significantly smaller weight gain than controls-3. Our study suggests that I3P, a gut bacteria metabolite of tryptophan, contributes to changes in body weight gain produced by antibiotics and tryptophan-rich diet.

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Obesity and the Use of Antibiotics and Probiotics in Rats

Cited by 19 publications

References 48 publications

Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model

Psychobiotic Effects of Multi-Strain Probiotics Originated from Thai Fermented Foods in a Rat Model

Obesity: A New Adverse Effect of Antibiotics?

Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats

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