Obesity as a significant risk factor for endometrial cancer

Suskic, Amer; Suskic, Sanela Halilovic; Oprić, Dejan; Maksimović, Siniša

doi:10.18203/2320-1770.ijrcog20162970

Cited by 4 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is due to the capability of the adipose tissue to collected hormones in a deposits, and also to interconvert and metabolize them vialocal enzymatic reactions that can significantly influence the practical conditions of the reproductive axis. This may explain the high concentrations of estrogen in obese women, compared to women with normal weight (Suskic et al, 2016). This may affect the Hypothalamic Pituitary Gonads axis (HPG) and the high estrogen creates a decrease in the secretion of GnRH hormone through negative response, causing menstrual disorder and an ovulation (Dag and Dilbaz, 2015).…”

Section: Resultsmentioning

confidence: 99%

The Impact of Obesity on Infertile Women with Polycystic Ovaries in Iraq

Daoud¹,

Khalil²,

Al-Taie³

et al. 2019

RJS

View full text Add to dashboard Cite

The study has focused on obesityin women with Polycystic Ovary Syndrome (PCOS), as a potential new indicator of infertility by evaluating twelve biochemical and hormonal variables such asprogesterone, estrogen, Follicle Stimulating Hormone (FSH), LH/FSH ratio, Luteinizing hormone (LH), Thyroid Stimulating Hormone (TSH), Prolactin, Cholesterol, Triglyceride (TG), Very Low Density Lipoprotein (VLDL). High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL). In all women, biochemical and hormonal tests have been examined. The effect of Waist to Hip ratio (WHR) and Body Mass Index (BMI) has been evaluated. The correlation between being afflicted with PCOS and WHR has been found to be positively correlated with LH, LH/FSH ratio, TSH, Cholesterol, TG, LDL and VLDL, whereas the negative correlation with estrogen, progesterone, FSH and HDL. Therefore, we conclude that WHR and BMI are new Indexes in obesity, indicating the increase of infertility with PCOS risk.

show abstract

Section: Resultsmentioning

confidence: 99%

The Impact of Obesity on Infertile Women with Polycystic Ovaries in Iraq

Daoud¹,

Khalil²,

Al-Taie³

et al. 2019

RJS

View full text Add to dashboard Cite

show abstract

“…the suppression of apoptosis, on the one hand, and increasing the proliferative potential, on the other hand. The main causes of hyperestrogenism include overweight, liver disease, adrenal glands, on the background of hypereinsulinemia and others [12]. According to the literature, in metabolic disorders, excess fat leads to higher estrogenic saturation of the body.…”

Section: Medicine and Dentistrymentioning

confidence: 99%

Comparative aspects of treatment of endometrial hyperplasia in women of reproductive age with overweight

Semeniuk

2021

Eureka: HS

View full text Add to dashboard Cite

The aim. Minimization of the frequency of recurrence of endometrial hyperplasia (EH) in women of reproductive age with overweight (OW) depending on the tactics of treatment. Materials and methods. 90 women of reproductive age with endometrial hyperplasia and OW were selected. They, in turn, were divided into three groups: group 1 – 30 women who took a gonadotropin-releasing hormone agonist (GnRH agonist), namely at a dose of 3.75 mg intramuscularly once every 28 days; group 2 – 30 women who used progestin (norethisterone) at a dose of 10 mg per day from day 16 to 25 of the cycle, group 3 – 30 women who took combined oral contraception (COC) (30 mcg ethinyl estradiol and 150 mcg desogestrel) in a cyclic mode 21/7. Evaluation of the effectiveness of therapy included a clinical picture of the disease 6 months after the start of treatment, assessment of the variability of the average values of endometrial thickness and uterine size on ultrasound (US) of the pelvis 6 months after treatment. Also analyzed the effectiveness of therapy based on the results of morphological examination of the endometrium in a biopsy of the uterine mucosa, performed 6 months after the start of treatment. In addition, a general analysis of the frequency of EH recurrence was performed 6–24 months after treatment. Results. The results showed that in the group in which women were prescribed GnRH agonist, there was a significantly higher effectiveness of treatment, in particular the absence of uterine bleeding and menstrual disorders (MD). At the same time, in the other norethisterone group, 53.3 % (16) of women had intermenstrual uterine bleeding. In patients in the group in which women received COC, uterine bleeding was observed in 30.0 % (i.e. 9) of patients (p <0.05). Immediately after treatment, the average values of endometrial thickness in patients of group 1, according to ultrasound, was 3.59±0.47 mm, which was significantly less than in women of groups 2 and 3 – 6.81±0.59 mm (p<0.001) and 7.58±0.69 mm (p<0.001). In addition, patients in group 1 at 3, 6, 12, 24 months after the end of hormone therapy were registered significantly lower average values of endometrial thickness, compared with patients receiving norethisterone and estrogen-progestogen drugs. Conclusions. In a comparative evaluation of the effectiveness of treatment of endometrial hyperplastic processes in overweight women, it was found that the recurrence rate after 6–24 months occurs in 6.7 % (i.e. 2) of patients after GnRH agonist therapy, in 33.3 % (i.e. in 10) patients receiving norethisterone (p<0.001), and in 50 % (i.e. 15) of women treated with COC (p<0.001).

show abstract

“…In the last few years, many studies have shown a relationship between obesity and cancers such as [1], [2], [5], [6], [7], [8]. Not only research in the medical field, but also the relationship between cancer and obesity also studied mathematically.…”

Section: Introductionmentioning

confidence: 99%

Stability of Cancerous Chemotherapy Model with Obesity Effect

Yanti

Habibah²

2019

CAUCHY

View full text Add to dashboard Cite

<p class="Body">In this paper we present stability of cancerous chemotherapy model with obesity effect. This is a four-population model that includes immune cells, cancer cells, normal cells, and fat cells. The analytical result shows that there are four equilibrium points in case the drugs given and fat cells were not equal to zero, i.e., dead equilibrium, total cancer invasion equilibrium, cancer-free equilibrium, and coexistence equilibrium. Some numerical simulation also presented to illustrate the results.</p>

show abstract

Obesity as a significant risk factor for endometrial cancer

Cited by 4 publications

References 6 publications

The Impact of Obesity on Infertile Women with Polycystic Ovaries in Iraq

The Impact of Obesity on Infertile Women with Polycystic Ovaries in Iraq

Comparative aspects of treatment of endometrial hyperplasia in women of reproductive age with overweight

Stability of Cancerous Chemotherapy Model with Obesity Effect

Contact Info

Product

Resources

About