Obesity; Association of Serum Vitamin D Levels

Rani, Keenjhar; Memon, Ali Raza; Akram, Muhammad; Memon, Paras Javed

doi:10.17957/tpmj/16.3322

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…According to our results, obese women were relatively more vitamin D deficient as compared to normal women. This is in accordance to two small studies carried out in local obese women [ 19 , 20 ]. These studies have used 20 ng/ml as the cutoff limit to define vitamin D deficiency, but we have used the latest cutoff level (12 ng/ml) for this purpose [ 18 ].…”

Section: Discussionsupporting

confidence: 93%

“…These studies have used 20 ng/ml as the cutoff limit to define vitamin D deficiency, but we have used the latest cutoff level (12 ng/ml) for this purpose [ 18 ]. In spite of the relatively lower cutoff value, our percentage of vitamin D-deficient obese women (40.7%) was comparable to that of one of the above mentioned studies, i.e., 40% [ 19 ]. As a consequence of relatively more vitamin D deficiency in obese women, the mean PTH concentration was significantly higher than in nonobese women (20.8 ± 15.9 versus 17.1 ± 12.7, respectively, P = 0.0034), but the mean serum calcium level was comparable in both groups.…”

Section: Discussionsupporting

confidence: 77%

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Prevalence of Vitamin D Deficiency and Its Association with Insulin Resistance in Obese Women with Normal Fasting Glucose

Saleem

Rizvi

Elahi

2021

BioMed Research International

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Background and Objective. Association of vitamin D (25-hydroxyvitamin-D; 25(OH)D), with glucose metabolism is ethnic dependent. We study the relation of vitamin D and its metabolites with the glycemic profile of obese women. Patients and Methods. Informed consent and demographic information was collected from obese ( BMI ≥ 30 kg / m 2 ) and nonobese women. A blood sample in fasting was obtained and analyzed for fasting glucose, fasting insulin, serum 25(OH)D, serum parathyroid hormone (PTH), and calcium levels. Insulin resistance (IR), detected by Matthews’ method (1985), was considered in women with HOMA − IR ≥ 2.5 . Vitamin D concentrations < 12 ng / ml were considered vitamin D deficiency. Results. A total of 264 obese and 133 normal BMI women (controls) of age range 20-50 years were selected. Obese women had significantly lower vitamin D compared to control women ( P < 0.05 ). Among euglycemic ( fasting glucose < 100 mg / dl ) obese women ( n = 221 ), 90 (40.7%) were vitamin D deficient. Serum PTH and calcium levels were negatively correlated, though nonsignificantly with vitamin D ( r = − 0.172 , P = 0.090 , and r = − 0.051 , P = 0.557 , respectively). The mean age, BMI, waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), fasting glucose, fasting insulin, PTH, and calcium were not significantly different in vitamin D-deficient as compared to nondeficient obese women. IR was detected in 109 (49.3%) obese women. Mean HOMA-IR in vitamin D-deficient women was significantly higher than that in the nondeficient obese women ( 3.03 ± 1.64 vs. 2.40 ± 1.02 ; P = 0.041 ), but the percentage of women with IR was comparable in both groups (51.1% vs. 45.8%; P = 0.745 ). Univariate analysis revealed that HOMA-IR was negatively correlated with vitamin D and positively with BMI and PTH. A multivariate regression analysis, stepwise method revealed that BMI and PTH were independent determinants of HOMA-IR instead of vitamin D. Conclusion. More than 40% of obese women were vitamin D deficient. Among euglycemic obese women, 49% were insulin resistant. Prevalence of insulin resistance, though negatively correlated with vitamin D, could be better explained by BMI and PTH levels.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 77%

Prevalence of Vitamin D Deficiency and Its Association with Insulin Resistance in Obese Women with Normal Fasting Glucose

Saleem

Rizvi

Elahi

2021

BioMed Research International

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“…These results matched a study carried out in Karachi where they found that 40% of obese patients were having hypovitaminosis D, but differed from our study in that they did not take diabetes into account. 19 Similarly, prevalence of hypovitaminosis D was found to be about 81% in Spanish obese children. 20 In summary, our study provided enough evidence for a possible association of hypovitaminosis D with poor glycemic control and obesity in type II diabetic patients, but large interventional studies implying vitamin d supplementation are needed to confirm our results.…”

Section: Although Vitamin D Deficiency Has Been Linkedmentioning

confidence: 96%

Association of hypovitaminosis D with poor glycemic control and obesity in type II diabetes mellitus.

Khan

Arshad

Khan³

2020

TPMJ

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Objectives: To determine the association of low serum vitamin D levels with poor glycemic control and obesity in type 2 diabetic patients. Study Design: Descriptive Cross Sectional study. Setting: Sakina Institute of Diabetes and Endocrine Research Centre (SIDER), Shalamar Hospital Lahore. Period: 1st June to 31th august 2017. Material & Methods: After applying strict exclusion criteria, about 450 patients with known type II diabetes were enrolled in the present study and their HBA1C and fasting vitamin D levels were measured. Patients were divided into two groups, group 1 with poor glycemic control (HBA1C>8%) and group 2 with good glycemic control (HBA1C <8%). Results: After performing extensive matching in both groups, it was found that vitamin D levels in group 1 with poor glycemic control were significantly low as compared to group 2 with good glycemic control (p value <0.001). Furthermore, approximately 87% of patients with BMI >23 were having suboptimal Vitamin D levels (p value <0.005). Conclusions: Low serum vitamin D is associated with poor glycemic control in type 2 diabetics and vitamin d supplementation could possibly play a role in improving glycemic control in these patients. Furthermore, hypovitaminosis D is also associated with obesity.

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Obesity; Association of Serum Vitamin D Levels

Abstract: Article Citation: Rani K, Memon AR, Akram M, Memon PJ. Obesity; association of serum vitamin d levels. Professional Med J 2016;23(6):665-668.

Cited by 2 publications

References 9 publications

Prevalence of Vitamin D Deficiency and Its Association with Insulin Resistance in Obese Women with Normal Fasting Glucose

Prevalence of Vitamin D Deficiency and Its Association with Insulin Resistance in Obese Women with Normal Fasting Glucose

Association of hypovitaminosis D with poor glycemic control and obesity in type II diabetes mellitus.

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