ObjectiveThe aim of this study was to explore the relationship between body frame size (BFS) and body image, self‐esteem, and health‐related quality of life (HRQL) in Mexican schoolchildren.MethodsThis cross‐sectional study included children aged 6 to 11 years. Body image, self‐esteem, and HRQL were evaluated through interviews. Two frame‐size measures, biacromial and bitrochanteric diameters, were collected and summed for categorizing BFS as small, medium, or large. Height and weight were also measured. Spearman's correlations were determined and adjusted by sex, age, and body mass index (BMI). Multiple logistic regression analyses were performed with the psychological measure as the binary dependent variable, the categories of BFS as the independent variable, and sex, age, and BMI as control variables.ResultsThe correlation between BFS and body image was 0.15 (P < .01) and after BMI adjustment was 0.07 (P > .05). BFS did not correlate with self‐esteem nor HRQL (P > .05). Of the children, 79% were dissatisfied with their body image, 20% had a low self‐esteem, and 31.8% had a poorly perceived HRQL; there were no differences by BFS. The multivariate analysis showed that a large BFS was not associated with body image dissatisfaction (OR 1.2, 95% CI 0.6‐2.3), low self‐esteem (OR 1.3, 95% CI 0.7‐2.6), or poor HRQL (OR 1.3, 95% CI 0.8‐2.2).ConclusionsBFS was not correlated with body image, self‐esteem, or HRQL. A high self‐esteem and a good level of HRQL prevailed, but a high proportion of children were dissatisfied with their body image. School interventions should promote an appropriate body image and a healthy lifestyle.