Obesity contributes to mortality and displays alterations in calcium, urea and hemoglobin levels in SARS-CoV-2 infected individuals

Rodrigues, Giovanna Uliana; Canella, Paula Renata Bueno Campos; Santos, Raquel de Cássia dos; Razolli, Daniela S.

doi:10.1016/j.clnesp.2022.05.024

Cited by 1 publication

(1 citation statement)

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“…Additionally, in a case-control study assessing the impact of BMI on COVID-19 mortality with a large sample size, the pooled results showed that patients with a BMI of 30 kg/m 2 had a considerably greater risk of COVID-19 mortality, according to the random effects model ( p < 0.001) [ 32 ]. In addition, a similar retrospective observational study of 125 medical records from HUSF indicated that obesity participates in metabolic changes and increased mortality in SARS-CoV-2-infected patients [ 33 ]. A recent meta-analysis showed that there was a linear dose-response association between BMI and severity and mortality due to COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Clinical Outcomes in Adult COVID-19 Patients of Diverse Ethnicities

et al. 2022

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(1) Background: Body mass index (BMI) was observed to affect COVID-19 outcomes; however, the complete spectrum of clinical outcomes concerning BMI remains unexplored. The current study aimed to investigate the correlation between BMI and the severity and mortality of COVID-19, as well as ICU admission, radiological findings, clinical presentation, and time to viral clearance. (2) Methods: This retrospective study included 1796 multiethnic patients with COVID-19 treated at NMC Royal Hospital, Abu Dhabi, UAE. (3) Results: COVID-19’s adjusted odds of severity increased by 3.7- and 21.5-fold in classes I and III, respectively (p = 0.001). The odds of mortality were not significantly different after adjustment for age, sex, and race. The adjusted odds of ICU admission increased significantly by 3-fold and non-significantly by 4-fold in obesity classes I and II, respectively. Pneumonia was significantly higher in patients who were overweight and class I, II, and III obese. Furthermore, class III obese patients had a greater risk of presenting with combined respiratory and gastrointestinal manifestations (p < 0.001). The median time to viral clearance with a BMI > 40 kg/m2 was moderately higher than that with a BMI < 40 kg/m2. (4) Conclusions: High BMI was associated with pneumonia, ICU admission, severity, and mortality due to COVID-19.

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Section: Discussionmentioning

confidence: 99%