2023
DOI: 10.1016/j.isci.2023.106071
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Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment

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Cited by 5 publications
(7 citation statements)
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“…Unlike iNKT cells and adaptive lymphocytes, innate lymphoid cells lack expression of a TCR and mainly respond to cytokine cues in the milieu [122]. In particular, systemic SHIP1 pharmacological inhibition in mice increases type 2 innate lymphoid cell (ILC2) production of cytokines, suggesting a role of SHIP1 in restraining the function of these cells [123].…”
Section: Ship1–a Suppressor Of Innate Immunitymentioning
confidence: 99%
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“…Unlike iNKT cells and adaptive lymphocytes, innate lymphoid cells lack expression of a TCR and mainly respond to cytokine cues in the milieu [122]. In particular, systemic SHIP1 pharmacological inhibition in mice increases type 2 innate lymphoid cell (ILC2) production of cytokines, suggesting a role of SHIP1 in restraining the function of these cells [123].…”
Section: Ship1–a Suppressor Of Innate Immunitymentioning
confidence: 99%
“…SHIP1 was found to be upregulated in diet‐induced obese mice [206]. SHIP1 or pan‐SHIP1/2 inhibition in diet‐induced and age‐induced obese mice reverses both obesity and hyperglycemia via eosinophil‐dependent mechanisms [123, 207]. This likely occurs via a SHIP1 inhibition‐mediated increase in IL‐4 secretion by eosinophils, which drives the polarization of macrophages to an M2‐like phenotype [123].…”
Section: Therapeutic Avenuesmentioning
confidence: 99%
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