Obesity, Diabetes and the Risk of Colorectal Adenoma and Cancer

Abstract

Background: Colorectal cancer (CRC) is the fourth most commonly diagnosed gastrointestinal (GI) malignancy and the third leading cause of cancer-related death worldwide. In the current case-control study, an association between diagnosis of CRC, obesity and diabetes was investigated. Methods: Demographic characteristics, colonoscopy reports, history of drug, smoking, and medical history were collected from patients referred to a colonoscopy unit. The location, size and number of the polyps were recorded during the colonoscopy. Statistically, t -test was conducted for mean comparison for the groups. Pearson's chi-squared test (χ2) was applied to categorize variables. Five classification methods based on the important clinicopathological characteristics such as age, BMI, diabetes, family history of colon cancer was performed to predict the results of colonoscopy. Results: Overall, 693 patients participated in this study. In the present study, 115 and 515 patients were evaluated for adenoma/adenocarcinoma and normal colonoscopy, respectively. The mean age of patients positive for adenoma or adenocarcinoma were significantly higher than the negative groups (p value <0.001). Incidence of overweight and/or obesity (BMI> 25 kg/m2) were significantly higher in adenoma positive patients as compared to controls (49.9% and 0.9% respectively, p value= 0.04). The results also demonstrated a significant association between suffering from diabetes and having colon adenoma (OR=1.831, 95%CI=1.058–3.169, p value=0.023). The experimental results of 5 classification methods on higher risk factors between colon adenoma and normal colonoscopy data were more than 82% and less than 0.42 for the percentage of classification accuracy and root mean squared error, respectively. Conclusions: In the current study, the occurrence of obesity measured based on BMI and diabetes in the adenoma positive patient group was significantly higher than the control group although there was no notable association between obesity, diabetes and adenocarcinoma.

Integration analysis of long non-coding RNA (lncRNA) role in tumorigenesis of colon adenocarcinoma

“…Colon adenocarcinoma (COAD) is one of the most common gastrointestinal (GI) cancers and is the second leading cause of cancer-related death, globally [ 1 , 2 ]. It is demonstrated that COAD occurs in approximately 5% of overall population at any given time in the world [ 3 ]. Despite the current screenings and therapies such as endoscopic resection and radical surgery, nearly half of the patients are diagnosed as advanced cases of COAD, experiencing tumor recurrence and relapse.…”

Opportunistic use of radiological measures of visceral adiposity for assessment of risk of colorectal adenoma

“…Nevertheless, the adenoma detection rate (27%) is this study is similar to large population colonoscopy study (19.4%). 23 Given the retrospective nature, the other risk factors such as diabetes mellitus, 24 hyperlipidemia, 25 smoking, family history of colorectal cancers 26 and use of aspirin/non-steroidal antiinflammatory drugs 14 were not investigated. These factors have been well studied in the literature.…”

Application of Deep Learning for Early Screening of Colorectal Precancerous Lesions under White Light Endoscopy

“…Here is their definition: mean average precision (AP): AP: AP at IoU = 0:50 : 0:05 : 0:95 (primary challenge metric), AP 50 : AP at IoU = 0:50, AP 75 : AP at IoU = 0:75, AP S : AP for small objects: area < 32 2 , AP M : AP for medium objects: 32 2 < area < 96 2 , AP L : AP for large objects: area > 96 2 . Average recall (AR): AR: AR given 1 detection per image, AR 10 : AR given 10 detections per image, AR 100 : AR given 100 detections per image, AR S : AR for small objects: area < 32 2 , AR M : AR for medium objects: 32 2 < area < 96 2 , AR L : AR for large objects: area > 96 2 . The results are shown in Table 2.…”

“…With the improvement of Chinese people's living standards, the incidence of CRC increases year by year. The most common precancer disease of CRC is colorectal adenoma (CRA) [2]. At present, total colonoscopy is still the best screening method for colorectal polyps, CRA, and CRC [3].…”