Obesity: Friend or foe for osteoporosis

Sharma, Sudhaa; Tandon, Vishal R; Mahajan, Sonia; Mahajan, Vivek; Mahajan, Annil

doi:10.4103/0976-7800.127782

Cited by 45 publications

(43 citation statements)

References 23 publications

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“…In turn, it has been suggested that the reduction in body weight brings about bone loss [2]. However, it should be stressed that body weight consists of two major components -fat mass (FM) and lean mass (LM) both contributing to mechanical stress, and many efforts have been made to establish their individual impact on bone health [3].…”

Section: Introductionmentioning

confidence: 99%

Relationships between bone mineral density and new indices of body composition in young, sedentary men and women

Kęska¹,

Lutosławska²,

Bertrandt

2018

Ann Agric Environ Med.

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Introduction. Data concerning the relationship between body fat and BMD are equivocal since both positive and negative effects have been noted. Recently, the index of fat mass (IFM) representing subjects with different body fat and similar lean mass and index of lean mass (ILM) representing subjects with different lean body mass and similar body fat, have been used to evaluate body composition effect on BMD in middle-aged women. This study aimed at determination of ILM and IFM association with BMD in young men and women. Materials and methods. A total of 212 university students of Public Health (125 women and 87 men) participated in the study. Body composition was determined by the bioelectrical impedance method (BIA) using BC 418 MA equipment (Tanita Co., Japan). Fat mass and fat free mass were used to calculate ILM and IFM. Bone mineral density was measured on the wrist of the non-dominant hand using the DEXA method and EXA 3000 equipment (HFS Ltd., Korea). BMD was evaluated using Z-score, with values lower than -2.0 indicating inadequate BMD for subject chronological age. Results. Exclusively in women, IFM was markedly and positively correlated with Z-score (r=0.366, P<0.001). In both genders, a significant relationship was found between ILM and Z-scores (r=0.420; p<0.001 and r=0.220; p<0.02 in men and women, respectively). Women with lower than median IFM but similar ILM, were characterized by significantly lower Z-scores vs. women with higher IFM (-1.016 vs. -0.512; p<0.001). Irrespective of gender, participants with higher ILM but similar IFM, were characterized by markedly higher Z-score vs. their counterparts with low ILM. Conclusions. The use of IFM and ILM in the present study, allowed the observation that in young adults lean body mass was associated with BMD, regardless of gender, while fat mass is significant for bone mineral density only in women.

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Section: Introductionmentioning

confidence: 99%

Relationships between bone mineral density and new indices of body composition in young, sedentary men and women

Kęska¹,

Lutosławska²,

Bertrandt

2018

Ann Agric Environ Med.

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“…There is further evidence that the relationship between weight and fracture risk is site-specific [6], [8], [10], [12]. The results of a meta-analysis of 60,000 men and women from 12 prospective, population based cohorts show that total fractures, osteoporotic fractures and hip fractures are all inversely correlated to the body mass index (BMI) in both men and women [6].…”

Section: Introductionmentioning

confidence: 99%

“…[12]. It has also been reported that age and female gender increase the risk of developing both obesity and osteoporosis [6].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the excessive secretion of leptin and/or decreased production of adiponectin by adipocytes in obesity may either directly affect bone formation or indirectly affect bone resorption through up-regulated pro-inflammatory cytokine production. Finally, the high fat intake may interfere with the intestinal calcium absorption and therefore decrease calcium availability for the bone formation [2]- [4], [7], [9], [12].…”

Section: Introductionmentioning

confidence: 99%

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Bone Mineral Density and Trabecular Bone Score in Ukrainian Women with Obesity

Povoroznyuk

Dzerovych

Martynyuk

et al. 2016

Journal of Clinical Densitometry

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Abstract-Obesity and osteoporosis are the two diseases whose increasing prevalence and high impact on the global morbidity and mortality, during the two recent decades, have gained a status of major health threats worldwide. Obesity purports to affect the bone metabolism through complex mechanisms. Debated data on the connection between the bone mineral density and fracture prevalence in the obese patients are widely presented in literature. There is evidence that the correlation of weight and fracture risk is sitespecific. This study is aimed at determining the connection between the bone mineral density (BMD) and trabecular bone score (TBS) parameters in Ukrainian women suffering from obesity. We examined 1025 40-89-year-old women, divided them into the groups according to their body mass index: Group A included 360 women with obesity whose BMI was ≥30 kg/m 2 , and Group B -665 women with no obesity and BMI of <30 kg/m 2 . The BMD of total body, lumbar spine at the site L1-L4, femur and forearm were measured by DXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L1-L4 was assessed by means of TBS iNsight® software installed on our DXA machine (product of Med-Imaps, Pessac, France). In general, obese women had a significantly higher BMD of lumbar spine, femoral neck, proximal femur, total body and ultradistal forearm (p<0.001) in comparison with women without obesity. The TBS of L1-L4 was significantly lower in obese women compared to nonobese women (p<0.001). The BMD of lumbar spine, femoral neck and total body differed to a significant extent in women of 40-49, 50-59, 60-69 and 70-79 years (p<0.05). At same time, in women aged 80-89 years the BMD of lumbar spine (p=0.09), femoral neck (p=0.22) and total body (p=0.06) barely differed. The BMD of ultradistal forearm was significantly higher in women of all age groups (p<0.05). The TBS of L1-L4 in all the age groups tended to reveal the lower parameters in obese women compared with the nonobese; however, those data were not statistically significant. By contrast, a significant positive correlation was observed between the fat mass and the BMD at different sites. The correlation between the fat mass and TBS of L1-L4 was also significant, although negative. Women with vertebral fractures had a significantly lower body weight, body mass index and total body fat mass in comparison with women without vertebral fractures in their anamnesis. In obese women the frequency of vertebral fractures was 27%, while in women without obesity -57%.

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“…Many women experience weight gain and fat accumulation in the waist region during their menopausal Biochemistry & Physiology: Open Access period [14]. It is already reported that postmenopausal women are more prone to develop adiposity/obesity and its associated pathological sequelae when compared to the men of peer age [15]. Adipose tissue is not only a lipid storage organ, it is also considered as one of the positive instigators in the expansion of components of metabolic syndrome [16,17].…”

Section: Postmenopausal Inflammationmentioning

confidence: 99%

Soy Isoflavones (from Glycine max) in Menopause Health and Diseases

Sankar¹,

Bobby²,

Mirza³

2017

Biochem Physiol

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As per the third consensus meeting of Indian Menopause Society reports, the number of postmenopausal women in India is approximately 43 million and it is projected to be 103 million by 2026. While the average age for menopause in India is 47.5 years, there is an alarming increase of premature menopause among the Indian women has been reported recently. It has been observed that, nearly four per cent women of age group of 29-34 years attain menopause and its incidence increases to eight per cent in women of age group between 35 and 39 years. The reason for this early menopause is still unclear, but it is a major public health problem because of its influence on the development of components of metabolic syndrome. Despite HRT improves postmenopausal complications, the prolonged use of HRT was not recommended now due to its influence on the development of certain types of cancers; endometrial cancer and breast cancer in addition to its negative impact on cardiovascular diseases. Hence, understanding the cellular and molecular mechanisms which amenable for the pathogenesis of postmenopausal complications may open new clinical therapeutic targets for the management of these complications. Soy isoflavones, a natural phytoestrogen, which shares the structural and functional homogeneity with estrogen. Several studies have reported that soy isoflavones have beneficial effects against ovariectomy (surgical menopause) as well as diet induced metabolic complications in animal models; however, its efficacy in terms of improving metabolic complications associated with postmenopausal state is largely unclear.

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Obesity: Friend or foe for osteoporosis

Cited by 45 publications

References 23 publications

Relationships between bone mineral density and new indices of body composition in young, sedentary men and women

Relationships between bone mineral density and new indices of body composition in young, sedentary men and women

Bone Mineral Density and Trabecular Bone Score in Ukrainian Women with Obesity

Soy Isoflavones (from Glycine max) in Menopause Health and Diseases

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