Obesity has a greater impact on IVF success rates in patients with PCOS

Gorelick, A.N.; Karvir, H.; Elashoff, Michael; Parfitt, D.-E.; Copperman, A.B.; Beim, P. Yurttas

doi:10.1016/j.fertnstert.2014.07.315

Cited by 3 publications

(3 citation statements)

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“…This study analyzed the data of 45,000 embryo transfers and concluded that higher obesity levels (i.e., BMI values) resulted in a considerable increase in the inability to achieve clinical pregnancy via the use of autologous oocytes but resulted in no differences in the use of donor oocytes. Besides, it reported that the adverse effects of obesity were more evident in the group aged under 35 years (31). The present study observed the negative effects of obesity more specifically in the group aged above 35 years.…”

Section: Discussionsupporting

confidence: 67%

“…A retrospective study by Gorelick et al (31), which investigated 5208 IVF cycles with different diagnoses, included 439 cycles in PCOS patients and demonstrated that obesity did not have any effect on IVF outcomes in other groups, whereas among PCOS patients, obesity led to a twofold increase in the risk of failure in IVF treatment. In women with PCOS, various negative effects were identified, not only in the implantation rate but also in pregnancy and live birth outcomes (30).…”

Section: Discussionmentioning

confidence: 99%

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Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Kalem

Sarı

et al. 2016

J Turkish German Gynecol Assoc

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Results:Variations in cycle variables with BMI and age showed that IVF cycles were negatively affected by increases in obesity and age. Clinical pregnancy rates were found to be lower in the obese group than in the other groups, particularly in the age group above 35 years; however, this difference could not be proven statistically. Conclusion:The present study evaluated obesity and clinical pregnancy rates in IVF cycles in PCOS patients according to age groups, and particularly in the obese group, the clinical pregnancy rates were observed to be lower in the age group ≥35 years than in the other BMI groups; however, this difference was found to be statistically insignificant. (J Turk Ger Gynecol Assoc 2016; 17: 83-90) Keywords: PCOS, body mass index, age, IVF outcome Received: 31 December, 2015 Accepted: 8 March, 2016 Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome Bailey et al. (12) investigated the effect of BMI on the characteristics and outcomes of IVF cycles in PCOS and found lower clinical pregnancy rates in an obese PCOS group than in a lean group and a lower rate of ovarian hyperstimulation syndrome (OHSS) in the obese group. A woman's age is also an important factor in IVF success (13,14). The IVF success rate reduces with increasing age in PCOS, as in all infertile patient groups (15, 16). The literature contains a very limited number of studies that investigate age and BMI together. Heijnen et al. (17) reported that although BMI has a significant and negative effect on female fertility, this effect gradually decreases as women approach their mid-thirties and also in younger women receiving IVF. Above the age of 36 years, on the other hand, the effect of BMI on fertility becomes minimal. PCOS patients were not included in this study. The study by Metwally et al. (8) that investigated 426 IVF/ICSI cycles did not exclude PCOS patients and reported that although obesity does not affect oocyte quality, there is a reduction in embryo quality in patients under the age of 35 years. The hypothesis of the present study assumed that the effect of BMI on the IVF cycles of PCOS patients may vary with age. The present study aimed to investigate age-related variations in the effect of BMI on IVF outcomes. Material and MethodsThis was a cohort study conducted by retrospectively investigating the IVF cycles of 653 PCOS patients under the age of 40 years, who were diagnosed based on the Rotterdam criteria in Gürgan IVF clinic between 2005 and 2015. The study protocol was approved by the local ethics committee, and all patients included in the study provided informed consent. The patients were diagnosed with PCOS in accordance with the diagnostic criteria of the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam Consensus Meeting 2003 (18). Based on this set of criteria, two of the following three criteria are necessary for confirming a diagnosis: -Anovulation or Oligoovulation -Biochemical or Clinical Hyperandr...

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Kalem

Sarı

et al. 2016

J Turkish German Gynecol Assoc

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“…When looking at patients with purely male-factor infertility, similar results were obtained. These results suggest that it is BMI itself rather than underlying pathologies that contribute to the worsening outcomes with increasing BMI, conflicting with the hypothesis that PCOS is the underlying pathology affecting IVF success rates in obese patients (19) and confirming the findings of other studies with smaller datasets (14)(15)(16)(17)(18)(19)(20)(21)(22). The mechanism of the negative effect of BMI on IVF outcome is unclear.…”

Section: Discussioncontrasting

confidence: 48%

Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for Assisted Reproductive Technology registry

Provost

Acharya

et al. 2016

Fertility and Sterility

192

134

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Success rates in fresh autologous cycles, including those done for specifically PCOS or male-factor infertility, are highest in those with low and normal BMIs. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMIs. More research is needed to determine the causes and extent of the influence of BMI on IVF success rates in other patient populations.

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Obesity in Relation to Ovarian Response in IVF Treatment

Hashim¹,

Gehad²,

Khalid³

et al. 2018

ARSci

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Introduction: The effect of Body Mass Index (BMI), which reflects the woman's obesity, in IVF treatment cycle, remains unclear. In 1997, the World Health Organization (WHO) provided authoritative refinements to the overweight terminology and BMI cutoffs [1]. Objective: To verify the relationship between BMI and ovarian response in IVF treatment cycle. Design: Retrospective study. Materials & Methods: The study includes 2625 IVF treatment cycles performed in our IVF center in the period of 4 years. Patients were divided into five groups using the WHO criteria according to their BMI [2]. Cancellation rate, mean last E2 before hCG administration, mean endometrial thickness, mean duration of stimulation, number of eggs retrieved, fertilization rate, pregnancy and abortion rates were analyzed. The unpaired t-test was used in statistical analysis. Results: There was statistically significant less mean oestradiol level prior to hCG, less endometrial thickness and less number of simulation days as BMI gets higher. In contrast, there was a positive relationship between cancellation rate and higher BMI except with BMI >39 which was not, possibly due to lower number of patients available. But if we look at the cause of cancellation, it was 100% due to insufficient number of follicles obtained for this group (BMI >39). Also, days of stimulation are significantly lower for the same group of patients in comparison with the other groups. Retrieval, fertilization and pregnancy rates were not significant between all groups. Abortion rate gets significantly higher as BMI increased. Conclusion: Overweight affects ovulation, if we consider the cause of cancellation being insufficient number of follicles reflects the poor response. The fertilization and pregnancy rate were not affected once oocytes retrieved. The reduction of weight is an important How to cite this paper: Hashim, H., Gehad, M51Advances in Reproductive Sciences part of infertility treatment in obese women with regards to the ovarian response and abortion rate in IVF cycle.

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Obesity has a greater impact on IVF success rates in patients with PCOS

Cited by 3 publications

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Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Effect of body mass index and age on in vitro fertilization in polycystic ovary syndrome

Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for Assisted Reproductive Technology registry

Obesity in Relation to Ovarian Response in IVF Treatment

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