Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for Assisted Reproductive Technology registry

Provost, M.; Acharya, Kelly S.; Acharya, Chaitanya R.; Yeh, Jason S.; Steward, Ryan G.; Eaton, Jennifer L.; Goldfarb, J.; Muasher, Suheil J.

doi:10.1016/j.fertnstert.2015.11.008

Cited by 191 publications

(155 citation statements)

References 31 publications

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“…They also had significantly less oocytes retrieved, if compared with women with normal BMI, and correcting by age, although this is of little clinical significance. Cancellation rates were four-fold higher in obese patients than in women with a BMI < 30kg/m 2 ; however, this was much lower than cancellation rates reported by Provost et al (2016) . Pinborg et al (2011) also showed an increase in the likelihood of cycle cancellation, after adjusting for age.…”

Section: Discussionmentioning

confidence: 56%

“…Indeed, in the other large multicentric studies, undertaken in the USA, only 16.5% and 17.8% of patients undergoing ART were obese ( Luke et al. , 2011 ; Provost et al , 2016 ). This issue could be explained because of the rapid epidemiological changes in most developing countries over the last decades, with a nutritional transition, which impacts on the quality of food, resulting in a declining of malnutrition rates, but an increase in overweight and obesity ( Rivera et al.…”

Section: Discussionmentioning

confidence: 98%

“…Luke et al. (2011) reported that 23.4% of the women undergoing ART in the United States of America (USA) during 2007 were overweight and 16.5% were obese, and Provost et al. (2016) showed a similar prevalence of overweight (22.9%) and obesity (17.8%) within patients needing ART in USA from 2008 to 2010.…”

Section: Introductionmentioning

confidence: 99%

“…A recent report based on data from the Society for Assisted Reproductive Technology Registry (SART) showed that the prevalence of overweight and obesity was 22.9% and 17.8%, respectively, and pregnancy outcomes were more favorable in women with normal BMI, and it worsens as BMI increases ( Provost et al , 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Outcome of assisted reproductive technology in overweight and obese women

Mackenna¹,

Schwarze²,

Crosby³

et al. 2017

JBRA Assisted Reproduction

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ObjectiveThe main objective of this study was to assess the prevalence of overweight and obesity among patients undergoing assisted reproductive technology (ART) in Latin America and its consequences on treatment outcomes.MethodsWe used the Latin American Registry of ART to obtain women's age and body mass index (BMI), cancellation rate, number of oocytes retrieved and embryos transferred, clinical pregnancy, live birth and miscarriage rates from 107.313 patients undergoing autologous IVF and ICSI during four years; a multivariable analysis was performed to determine the effect of BMI on cancellation, oocytes retrieved, pregnancy, live birth and miscarriage, adjusting for age, number of embryos transferred and embryo developmental stage upon embryo transfer, when appropriate.ResultsThe prevalence of overweight and obesity was 16.1% and 42.4%, respectively; correcting for age of female partner, overweight and obesity were associated to an increase in the odds of cancellation and to a lower mean number of oocytes retrieved; after adjusting for age, number of embryos transferred and stage of embryo development at transfer, we found that the BMI category was not associated to a change in the likelihoods of pregnancy, live birth and miscarriage.ConclusionsThe prevalence of obesity among women seeking ART in Latin America is surprisingly high; however, BMI does not influence the outcome of ART performed in these women.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcome of assisted reproductive technology in overweight and obese women

Mackenna¹,

Schwarze²,

Crosby³

et al. 2017

JBRA Assisted Reproduction

View full text Add to dashboard Cite

show abstract

“…On the other hand, obese women under treatment for infertility may face additional problems, such as the need for higher doses of drugs to induce/stimulate ovulation, oocyte morphological changes, reduction in fertilization and implantation rates, and embryo quality (ASRM, 2015; Provost et al ., 2016). Compared to women of normal body weight, obese women submitted to IVF may present reduced rates of clinical pregnancy and live births, with an increased rate of abortion (Provost et al ., 2016). In addition, obese pregnant women have a higher incidence of maternal and fetal complications, such as gestational diabetes, hypertensive disorders of pregnancy and increased perinatal morbidity/mortality (Aune et al ., 2014).…”

mentioning

confidence: 99%

Obesity and Reproduction

Oliveira

2016

JBRA Assisted Reproduction

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AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5‐POLG Axis

Chen,

Ma,

Gai

et al. 2024

Advanced Science

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Due to the exclusive maternal transmission, oocyte mitochondrial dysfunction reduces fertility rates, affects embryonic development, and programs offspring to metabolic diseases. However, mitochondrial DNA (mtDNA) are vulnerable to mutations during oocyte maturation, leading to mitochondrial nucleotide variations (mtSNVs) within a single oocyte, referring to mtDNA heteroplasmy. Obesity (OB) accounts for more than 40% of women at the reproductive age in the USA, but little is known about impacts of OB on mtSNVs in mature oocytes. It is found that OB reduces mtDNA content and increases mtSNVs in mature oocytes, which impairs mitochondrial energetic functions and oocyte quality. In mature oocytes, OB suppresses AMPK activity, aligned with an increased binding affinity of the ATF5‐POLG protein complex to mutated mtDNA D‐loop and protein‐coding regions. Similarly, AMPK knockout increases the binding affinity of ATF5‐POLG proteins to mutated mtDNA, leading to the replication of heteroplasmic mtDNA and impairing oocyte quality. Consistently, AMPK activation blocks the detrimental impacts of OB by preventing ATF5‐POLG protein recruitment, improving oocyte maturation and mitochondrial energetics. Overall, the data uncover key features of AMPK activation in suppressing mtSNVs, and improving mitochondrial biogenesis and oocyte maturation in obese females.

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Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for Assisted Reproductive Technology registry

Cited by 191 publications

References 31 publications

Outcome of assisted reproductive technology in overweight and obese women

Outcome of assisted reproductive technology in overweight and obese women

Obesity and Reproduction

AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5‐POLG Axis

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