Obesity in Adolescence is Associated with Left Ventricular Hypertrophy and Hypertension

Movahed, Mohammad Reza; Bates, Sharon; Strootman, Deborah; Sattur, Sudhakar

doi:10.1111/j.1540-8175.2010.01289.x

Cited by 34 publications

(25 citation statements)

References 26 publications

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“…Hypertension has become more prevalent in the young adult population[10], and has been shown to cause increased LVM and even heart failure if left untreated[32]. With proper antihypertensive therapy LVH can regress and left ventricular dysfunction can improve[33,34].…”

Section: Discussionmentioning

confidence: 99%

“…Left ventricular hypertrophy (LVH) has a significant prevalence in the general population with some estimates approaching 16%-20% in population based samples[5,6], and up to 50% in those with hypertension[7-9]. As a result of the obesity epidemic, even the adolescent population has had a higher incidence of hypertension and LVH[10], with some estimates showing LVH in nearly 30% of younger hypertensive[11]. Thus, with the high prevalence of LVH that extends even into the young population and the increased cardiovascular risk it confers, it is important to identify patients with increased LVM so that they may receive appropriate care.…”

Section: Introductionmentioning

confidence: 99%

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Validity of electrocardiographic criteria for increased left ventricular mass in young patients in the general population

Sklyar

Ginelli

Barton

et al. 2017

WJC

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AIMTo investigate validity of electrocardiographic (ECG) criteria for left ventricular hypertrophy (LVH) in young adults.METHODSRetrospectively, echocardiograms showing LVH and concomitant electrocardiograms were collected in patients 18 to 39 years old. A control group of patients without LVH was collected. Using echocardiogram as the gold standard, electrocardiograms were analyzed using common voltage criteria.RESULTSStudy included 100 subjects (52% male, mean age = 28 ± 6.8 years, 96% Hispanic or African-American) with 50% LVH prevalence. Sensitivity and specificity for Sokolow-Lyon criteria were 24% (95%CI: 13.5%-38.4%) and 88% (95%CI: 74.9%-95%). For Cornell criteria, sensitivity was 32% (95%CI: 19.9%-46.8%) and specificity 98% (95%CI: 87.9%-99.8%). For R in aVL criteria, sensitivity was 12% (95%CI: 4.9%-25%) and specificity 100% (95%CI: 91.1%-100%).CONCLUSIONIn young adults common ECG voltage criteria have low sensitivities and high specificities similar to other age groups. Low sensitivities preclude these ECG criteria from serving as effective screening tests.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validity of electrocardiographic criteria for increased left ventricular mass in young patients in the general population

Sklyar

Ginelli

Barton

et al. 2017

WJC

View full text Add to dashboard Cite

show abstract

“…A number of cross sectional studies have identified factors associated with variation in left atrial size, finding that older age, hypertension, LV dilation and measures of obesity associate with larger LA volume. 7, 10–12 .…”

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confidence: 99%

Factors Associated With Left Atrial Remodeling in the General Population

Oliver

Matthews

Ayers

et al. 2017

Circ: Cardiovascular Imaging

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Background While contributors to remodeling of the left ventricle (LV) have been well studied in general population cohorts, few data are available describing factors influencing changes in left atrial (LA) structure. Methods and Results Maximum LA volume was determined by cardiac magnetic resonance imaging (cMRI) among 748 participants in the Dallas Heart Study at two visits a mean of 8 years apart. Associations of changes in LA volume (Δ LAV) with traditional risk factors, biomarkers, LV geometry and remodeling by cMRI, and detailed measurements of global and regional adiposity (by MRI and Dual-energy x-ray absorptiometry [DEXA]) were assessed using multivariable linear regression. Greater Δ LAV was independently associated with Black and Hispanic Race/Ethnicity, Δ systolic blood pressure, LV mass and Δ LV mass, NT-proBNP and Δ NT-proBNP and BMI (p< 0.05 for each). In subanalyses, the associations of ΔLAV with LV mass parameters were driven by associations with baseline and Δ LV end diastolic volume (p<0.0001 for each) and not wall thickness (p=0.21). Associations of ΔLAV with BMI were explained exclusively by associations with visceral fat mass (p=0.002), with no association seen between ΔLAV and subcutaneous abdominal fat (p=0.47) or lower body fat (p=0.30). Conclusions Left atrial dilatation in the population is more common in Black and Hispanic than white individuals, and is associated with parallel changes in the left ventricle. LA dilatation may be mediated by blood pressure control and the development of visceral adiposity.

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“…In fact, LVH has been shown to be more than four times more likely in obese adolescents than non-obese adolescents (Odds ratio [OR] 4.51, 95%CI 2. 83-7.19) [24]. However, the welldemonstrated protective effect of overweight and class I-II obesity in the patient who has an existing diagnosis of HF, known as the Bobesity paradox,^should be remembered [22].…”

Section: Myocardial Remodelingmentioning

confidence: 96%

Bariatric and Metabolic Surgery in Adolescents: a Path to Decrease Adult Cardiovascular Mortality

Beamish

Olbers

2015

Curr Atheroscler Rep

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Obesity is a major health problem across all age groups and has escalated to pandemic proportions. The proportion of children with overweight or obesity has risen rapidly over recent decades, and it is recognized that most obese children become obese adults. Furthermore, BMI is the strongest CV risk factor to track from childhood into adulthood. As well as BMI, multiple CV risk factors begin in childhood and strong associations between these factors and BMI are evident. Clear evidence exists for the CV benefits of reversing obesity in adults, much of which examines the effects of bariatric surgery. The capacity of bariatric surgery to reliably achieve safe and lasting improvement in BMI is unparalleled, and the emerging evidence base in adolescent bariatric surgery has so far concurred. In the absence of effective alternatives, it appears that the increase in use of bariatric surgery in adolescents will continue.

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Obesity in Adolescence is Associated with Left Ventricular Hypertrophy and Hypertension

Abstract: Obese adolescents have a significantly higher prevalence of HTN and LVH. Our analysis suggests a direct negative effect of obesity on cardiovascular function starting early in teenage years. (Echocardiography 2011;28:150-153).

Cited by 34 publications

References 26 publications

Validity of electrocardiographic criteria for increased left ventricular mass in young patients in the general population

Validity of electrocardiographic criteria for increased left ventricular mass in young patients in the general population

Factors Associated With Left Atrial Remodeling in the General Population

Bariatric and Metabolic Surgery in Adolescents: a Path to Decrease Adult Cardiovascular Mortality

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