Obesity, Inflammation, and Advanced Prostate Cancer

Olivas, Armando; Price, Ramona Salcedo

doi:10.1080/01635581.2020.1856889

Cited by 20 publications

(10 citation statements)

References 135 publications

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“…This absence of differences may be related to low activity exerted by TNF-α in a long-term response to perinatal BPA or E2. TNF-α has an active role in inflammation-associated cancers (Olivas & Price, 2020); here, however, despite the presence of proliferative lesions, there was no impact on TNF-α expression in either organ. In general, this factor may be directly involved in the initial development of malignancy, by contributing with an appropriate environment in the stroma (Balkwill, 2006).…”

Section: Discussioncontrasting

confidence: 57%

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Leonel

Ruiz

Bedolo

et al. 2021

Cell Biology International

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The mammary gland (MG) and female prostate are plastic reproductive organs which are highly responsive to hormones. Thus, endocrine disruptors, such as bisphenol A (BPA) and exogenous estrogens, negatively affect glandular homeostasis. In addition to previously described alterations, changes in inflammatory markers expression also trigger the development of a microenvironment that contributes to tumor progression. The current work aimed to evaluate the inflammatory responses of the MG and prostate gland to BPA (50 µg/kg) and 17‐β estradiol (35 µg/kg) exposure during the perinatal window of susceptibility. The results showed that at 6 months of age there was an increase in the number of phospho‐STAT3 (P‐STAT3) positive cells in the female prostate from animals perinatally exposed to 50 µg/kg BPA daily. In addition, the number of macrophages increased in these animals in comparison with nonexposed animals, as shown by the F4/80 marker. Despite an increase in the incidence of lobuloalveolar and intraductal hyperplasia, the MG did not show any difference in the expression of the four inflammatory markers evaluated: tumor necrosis factor‐α, COX‐2, P‐STAT3, and F4/80. Analysis of both glands from the same animal led to the conclusion that exposure to endocrine disruptors during the perinatal window of susceptibility leads to different inflammatory responses in different reproductive organs. As the prostate is more susceptible to these inflammatory mechanisms, it is reasonable to affirm that possible neoplastic alterations in this organ are related to changes in the inflammatory pattern of the stroma, a characteristic that is not evident in the MG.

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Section: Discussioncontrasting

confidence: 57%

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Leonel

Ruiz

Bedolo

et al. 2021

Cell Biology International

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“…Among modifiable factors, the dysregulation of hormonal pathways, due to several environmental factors, such as metabolic syndrome, obesity, hypercholesterolemia and processed foods intake, leads to increased serum insulin levels, inflammatory cytokines and estradiol, which predisposes to an increased high-grade PCa risk [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Liquid Biopsy in Prostate Cancer Management—Current Challenges and Future Perspectives

Crocetto

Russo

Zazzo

et al. 2022

Cancers

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Although appreciable attempts in screening and diagnostic approaches have been achieved, prostate cancer (PCa) remains a widespread malignancy, representing the second leading cause of cancer-related death in men. Drugs currently used in PCa therapy initially show a potent anti-tumor effect, but frequently induce resistance and PCa progresses toward metastatic castration-resistant forms (mCRPC), virtually incurable. Liquid biopsy has emerged as an attractive and promising strategy complementary to invasive tissue biopsy to guide PCa diagnosis and treatment. Liquid biopsy shows the ability to represent the tumor microenvironment, allow comprehensive information and follow-up the progression of the tumor, enabling the development of different treatment strategies as well as permitting the monitoring of therapy response. Liquid biopsy, indeed, is endowed with a significant potential to modify PCa management. Several blood biomarkers could be analyzed for diagnostic, prognostic and predictive purposes, including circulating tumor cells (CTCs), extracellular vesicles (EVs), circulating tumor DNA (ctDNA) and RNA (ctRNA). In addition, several other body fluids may be adopted (i.e., urine, sperm, etc.) beyond blood. This review dissects recent advancements and future perspectives of liquid biopsies, highlighting their strength and weaknesses in PCa management.

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“…Inflammation is an important protective response against tissue damage or pathogens; however, uncontrolled chronic inflammatory reactions can cause various chronic diseases, including kidney disease, diabetes mellitus, and malignancies [19][20][21]. In addition, inflammation is associated with many diseases such as microbial and viral infections, exposure to allergens, radiation and toxic chemicals, autoimmune diseases, obesity, alcohol consumption, and tobacco use [22].…”

Section: A Brief Overview Of Inflammation and Oxidative Stress In Bph 21 Pathological Roles Of Inflammation And Oxidative Stressmentioning

confidence: 99%

“…Several investigators have suggested that inflammation plays important roles in the pathogenesis of prostate diseases, including BPH and prostate cancer [21,32]. Inflammation affects the balance between prostate cell proliferation and apoptosis by increasing factors such as cytokines, COX-2, and oxidative stress around the prostate [32].…”

Section: Benign Prostate Hyperplasia and Inflammationmentioning

confidence: 99%

Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia

et al. 2021

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Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action.

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Obesity, Inflammation, and Advanced Prostate Cancer

Cited by 20 publications

References 135 publications

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17‐β estradiol

Liquid Biopsy in Prostate Cancer Management—Current Challenges and Future Perspectives

Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia

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