Obesity, Inflammation and Diet

Lee, Hansongyi; Lee, In Seok; Choue, Ryowon

doi:10.5223/pghn.2013.16.3.143

Cited by 238 publications

(209 citation statements)

References 74 publications

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“…Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related cardiovascular diseases (Hajer et al, 2008). Currently, obesity is regarded as a state in which chronic low-grade inflammation persists in adipose tissues (Lee et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Matsui

Tomaru

Miyoshi

et al. 2014

Experimental and Molecular Pathology

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Obesity is a state in which chronic low-grade inflammation persists in adipose tissues. Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related diseases. Since TNF-α converting enzyme (TACE) is the major factor that induces soluble TNF-α, TACE has been noted as a pivotal regulator in this field. To reveal the role of TACE in adipose tissue inflammation, TACE-transgenic (TACE-Tg) and wild type (WT) mice were fed with high fat diet (HFD) or control diet for 16 weeks. At 13 weeks after the beginning of the diet, serum TNF-α and macrophage-related cytokine/chemokine levels were elevated in TACE-Tg mice fed with HFD (Tg-HFD mice), and the number of so-called crown-like adipocyte was significantly increased in adipose tissues of Tg-HFD mice at the end of the experiment. Although macrophage infiltration was not detected in the adipose tissues at this time, fibrosis was observed around the crown-like adipocytes. These findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under HFD regimen. The collective evidence suggested that TACE could be a therapeutic target of HFD-induced obesity-related adipose tissue inflammation.

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Section: Introductionmentioning

confidence: 99%

Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Matsui

Tomaru

Miyoshi

et al. 2014

Experimental and Molecular Pathology

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“…Also, exogenous or endogen fatty acid as well as exogenous lipopolysaccharide are capable of inducing inflammation in adipose tissue through the activation of toll-like receptors present in both adipocytes and macrophages. However, the factors produced by the adipose tissue, both hormones and cytokines, have effect over other cell types including lymphocytes, dendritic cells, and neutrophils among others, affecting different mechanisms related with the production and release of multiple cytokines of the innate and adaptive response [16,17,33] (Figure 4). Now, the functionality of the adipose tissue under obesity condition have gained considerable interest mainly by its relationship with different diseases including diabetes, cardiovascular disease, metabolic syndrome, and its possible association with joint diseases [34,35].…”

Section: Relationship Among Adipokines and Immune Systemmentioning

confidence: 99%

“…Resistin is a hormone implicated in resistance of insulin, and visfatin is a hormone with implication in the utilization of glucose. However, these hormones also are implicated in inflammation process and they can interact with cells of the innate and adaptive immune system modulating the production of cytokines from adipocytes and the stromal-vascular fraction [16,17] (Figure 3). …”

Section: Hormonesmentioning

confidence: 99%

Adipose Tissue and Inflammation

Muñoz‐Carrillo¹,

Campo²,

Coronado³

et al. 2018

Adipose Tissue

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Adipose tissue is composed mainly by adipocytes and stromal-vascular fraction, which are composed by different cell types including macrophages. There are three types of adipose tissue: brown (BrAT), white (WAT), and beige (BeAT). BrAT is less abundant and is implicated in lipid oxidation and energy balance; BeAT has the pathway of adaptive thermogenesis, and WAT is endocrine in nature and lipid storage site and is implicated as an endocrine organ that secretes hormones and different molecules. These molecules are pro-inflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, leptin, adiponectin, and others, are involved with the development of adipose tissue inflammation and obesity. This pathological condition, together with other factors such as oxidative stress, may develop insulin resistance and the pathogenesis of type 2 diabetes mellitus (T2DM).

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“…The intake of polyunsaturated acids was inversely associated with biomarkers of inflammation (C-reactive protein [CRP], interleukin [IL]-6, and TNF-α), while intake of trans and saturated acids was positively associated with levels of CRP and IL-6. 53 Wei et al studied the relationship between food and psoriasis in 646 psoriasis subjects and 647 healthy controls. 54 Results showed that alcohol consumption, spicy foods, and fat-rich meat were risk factors for psoriasis (P,0.01), while protein-rich meat and vegetable oil were protective factors (P,0.01).…”

Section: Dietmentioning

confidence: 99%

Epidemiology and treatment of psoriasis: a Chinese perspective

Pan¹,

Zhang²

2014

PTT

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Background: Psoriasis is a chronic inflammatory skin disease that has a negative impact on quality of life. Prevalence and management of psoriasis varies among different ethnic groups. Objectives: To evaluate the epidemiology and treatment of psoriasis from a Chinese perspective. Methods: A systematic search was performed on PubMed and the China National Knowledge Infrastructure using the following MeSH terms: "psoriasis" and ("prevalence" or "epidemiology") and "risk factor" and ("management" or "treatment"). The search included all citations from 1975 to 2013. Data were sorted by prevalence, age of onset, sex distribution, type, severity, risk factors, and management and treatment. Severity of psoriasis was classified as mild, moderate, or severe. The studies cited in this review involved Chinese subjects. Results: The prevalence of psoriasis in the People's Republic of China ranged from 0.11% to 0.47%. Genetic and environmental factors played an important role in initiation and exacerbation of psoriasis. Results showed that psoriasis can occur at any age but is more common in young and middle-aged individuals and occurs more often in men and earlier in women. Psoriasis vulgaris accounted for 82.6%-97.1% of psoriasis patients. More than 90% of patients with psoriasis were classified as mild or moderately severe. Risk factors are numerous. Management and treatment was based on classification level. Conclusion:The prevalence of psoriasis in Chinese patients is lower than that in Caucasians. A cold and dry climate, bacterial infection, diet, and stress are important risk factors for developing psoriasis. There are a variety of management and treatment options available. As such, Chinese patients with psoriasis can receive effective, safe, and individualized treatment.

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Obesity, Inflammation and Diet

Cited by 238 publications

References 74 publications

Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

Adipose Tissue and Inflammation

Epidemiology and treatment of psoriasis: a Chinese perspective

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