2013
DOI: 10.1016/j.bcmd.2013.01.010
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Obesity is associated with higher overall survival in patients undergoing an outpatient reduced-intensity conditioning hematopoietic stem cell transplant

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Cited by 26 publications
(18 citation statements)
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“…Given the hypermetabolic state patients endure due to stress placed on the body during transplant, nutrition can be an important factor in patient outcomes and a patient's BMI can help determine nutritional status before transplant. [18][19][20][21] The improved 100-day mortality in the obese group could be attributed to nutritional reserves that prevented malnutrition during the transplant process. Pretransplant assessment of performance status and comorbidities is an important aspect in determining a patient's ability to tolerate SCT.…”
Section: Discussionmentioning
confidence: 99%
“…Given the hypermetabolic state patients endure due to stress placed on the body during transplant, nutrition can be an important factor in patient outcomes and a patient's BMI can help determine nutritional status before transplant. [18][19][20][21] The improved 100-day mortality in the obese group could be attributed to nutritional reserves that prevented malnutrition during the transplant process. Pretransplant assessment of performance status and comorbidities is an important aspect in determining a patient's ability to tolerate SCT.…”
Section: Discussionmentioning
confidence: 99%
“…Nutritional well-being of post-HSCT patients has been measured relatively simply as body mass index (BMI), using height and weight, as muscle mass and fat tissue using mid-arm circumference and skinfold triceps measurements (Muscaritoli, Grieco, Capria, Iori, & Fanelli, 2002), or with bioelectrical impedance (Jaime-Pérez et al, 2013) or whole body dual-energy x-ray absorptiometry (Kyle et al, 2005). Among adults in two studies, significant weight loss of 12 kilograms occurred between transplant and engraftment (Jaime-Pérez et al, 2013), and significant lean BMI loss of 1.0 kg/m2 and a body fat mass loss of 1.2 kg/m2 occurred over 6 months that was not regained by one-year post HCST (Kyle et al, 2005), respectively. Children and adolescents experienced significant declines in weight, skinfold triceps, and mid-arm circumference measurements from baseline to 4 months post-HSCT, illustrating a significant loss of muscle mass and fat tissue (Rodgers et al, 2008).…”
Section: Significance and Backgroundmentioning
confidence: 99%
“…Jaime-Pérez and colleagues (2013) studied albumin levels between HSCT and engraftment in 77 adult patients and found no significant change. Uderzo and colleagues (1991) studied albumin and prealbumin levels during total parenteral nutrition (TPN) supplementation after HSCT in 25 pediatric patients.…”
Section: Significance and Backgroundmentioning
confidence: 99%
“…Although results for efficacy and tolerability of high-dose chemotherapy with HCT in overweight patients are inconsistent, the prevailing concept is that high-dose chemotherapy and HCT can be safely administered in overweight and obese patients without increased adverse effects or compromised outcomes. [9][10][11] In a recent perspective, we recommended dosing on the basis of adjusted body weight (Adj BW) to partially increase the dose relative to increased body mass and to then conduct studies to further increase dosing until full body weight is used as the basis for calculation, or dose-limiting toxicity is reached. 12 After a comprehensive literature review, the American Society of Blood and Marrow Transplantation Practice Guidelines Committee subsequently concluded that there was insufficient data to make evidence-based recommendations for how to dose high-dose chemotherapy in obese patients.…”
mentioning
confidence: 99%