Obesity Management in Cardiometabolic Disease: State of the Art

Iwamoto, Sean J.; Abushamat, Layla A.; Zaman, Adnin; Millard, Anthony J.; Cornier, Marc‐Andre

doi:10.1007/s11883-021-00953-0

Cited by 18 publications

(12 citation statements)

References 88 publications

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“…Weight loss intervention among overweight and obese adults could improve others CMR profile (Liyana et al, 2018;Morris et al, 2021), suggesting that obesity management should be an integral part to modify the risk of cardiometabolic disorders (Iwamoto et al, 2021). However, this review found that digital-based intervention was not associated with decrease in others CMR profile, such as blood pressure, HbA1c, HDL cholesterol, triglyceride, and total cholesterol.…”

Section: Discussionmentioning

confidence: 83%

Digital Health Interventions to Improve Cardiometabolic Risk Profile among Adults with Obesity and Chronic Diseases: A Systematic Review

Nisa

Barsbay

2022

Nurs. Med. J. Nursing

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Background: The prevalence of chronic diseases is rapidly increasing globally. Ubiquitous digital technologies give an opportunity for digital health intervention to improve cardiometabolic risk (CMR) profile that may consequently decrease the risk of chronic diseases. However, evidence on digital health associated with chronic disease interventions remains controversial.Purpose: This systematic review aimed to determine the association of digital health intervention with improving CMR profile of adults with obesity and chronic diseases.Methods: A comprehensive search of Medline, CINAHL, Embase, and PubMed was performed using the following criteria: publication between 2016-2021, using digital health tools as interventions, adults with obesity or chronic diseases, cardiometabolic profile as outcomes, and randomized controlled trial (RCT) as the design. The search yielded 548 articles of which 13 studies met the inclusion criteria. The Joanna Briggs checklist for RCT was used to assess the quality of the studies. Data analysis was conducted according to the guidance for synthesis without meta-analysis.Results: There were 8 (61.5%) out of 13 studies assessed the relationship between digital health interventions and weight, of which 7 studies (88%) found positive findings. The association between digital health intervention and blood pressure were assessed in 7 (53.8%) out 13 studies, of which only two studies had positive findings related with systolic blood pressure. The intervention modalities included m-Health (apps) in 2 studies, text-messaging in 4 studies, and combinations of modalities in 8 studies. The interventions used different strategies, including education, self-management, and social support. More than a half of the studies (54%) were about weight-loss interventions and 10 (76.9%) studies used education for intervention components.Conclusions: Digital health intervention may be associated with decreased weight and BMI; however, only a few studies assessed other CMR profile, and the findings were inconsistent. Additional studies are needed to assess digital health interventions targeting other CMR profile, including blood pressure, glucose, and cholesterol level.

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Section: Discussionmentioning

confidence: 83%

Digital Health Interventions to Improve Cardiometabolic Risk Profile among Adults with Obesity and Chronic Diseases: A Systematic Review

Nisa

Barsbay

2022

Nurs. Med. J. Nursing

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“…Obesity is a risk factor for CVD and is closely related to other risk factors of CVD. Reducing obesity should be an important component of a CVD management strategy [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

The Chain-Mediating Effect of Obesity, Depressive Symptoms on the Association between Dietary Quality and Cardiovascular Disease Risk

Zhang

Limei

et al. 2023

Nutrients

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In order to explore the relationship between the Healthy Eating Index (HEI-2015) and cardiovascular disease (CVD), and the mediating role of obesity and depressive symptoms, we used the data from the 2011–2018 National Health and Nutrition Examination Survey (NHANES) for further study. A total of 12,644 participants were included in the study. The HEI was derived using NHANES personal food data and USDA Food Pattern Equivalence Database (FPED) dietary data. The risk of cardiovascular disease was determined using the Framingham Heart Study’s multifactorial calculation tool. The weighted multiple logistic regression model was used to explore the association between the HEI-2015 and CVD, and the generalized structural equation was used to explore the mediating effects of obesity and depression, respectively and jointly. Higher HEI-2015 scores were associated with a lower risk of CVD compared to lower quartiles. Obesity, depressive symptoms, and their chain effects all played significant mediating roles in the association between the HEI-2015 and CVD, with proportional mediations of 9.03%, 2.23% and 0.25%, respectively. Our results suggest that higher dietary quality is associated with a lower risk of CVD, mediated by obesity, depressive symptoms, and the chain effect of obesity and depressive symptoms.

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“…Among the major causes of CMD and related complications is DM. Obesity usually predisposes to DM, especially central obesity per se, and is associated with severe comorbidities, influencing every system of organs, particularly affecting cardiometabolic comorbidities (60). Moreover, obesity is associated with an increased risk for CVD independently from other CVD risk factors and is also considered a modulator of other CVD risk factors.…”

Section: Cmdmentioning

confidence: 99%

The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases

Obradović

Sudar-Milovanović²,

Gluvić³

et al. 2023

Front. Endocrinol.

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Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute to the development of multisystem diseases such as cardiovascular diseases and diabetes mellitus (DM). CMD has reached epidemic proportions worldwide. A sodium pump (Na+/K+-ATPase) is found in most eukaryotic cells’ membrane and controls many essential cellular functions directly or indirectly. This ion transporter and its isoforms are important in the pathogenesis of some pathological processes, including CMD. The structure and function of Na+/K+-ATPase, its expression and distribution in tissues, and its interactions with known ligands such as cardiotonic steroids and other suspected endogenous regulators are discussed in this review. In addition, we reviewed recent literature data related to the involvement of Na+/K+-ATPase activity dysfunction in CMD, focusing on the Na+/K+-ATPase as a potential therapeutic target in CMD.

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Obesity Management in Cardiometabolic Disease: State of the Art

Cited by 18 publications

References 88 publications

Digital Health Interventions to Improve Cardiometabolic Risk Profile among Adults with Obesity and Chronic Diseases: A Systematic Review

Digital Health Interventions to Improve Cardiometabolic Risk Profile among Adults with Obesity and Chronic Diseases: A Systematic Review

The Chain-Mediating Effect of Obesity, Depressive Symptoms on the Association between Dietary Quality and Cardiovascular Disease Risk

The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases

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