Obesity paradox and aging

Bosello, O; Vanzo, Angiola

doi:10.1007/s40519-019-00815-4

Cited by 123 publications

(87 citation statements)

References 64 publications

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“…However, one should also consider the so-called "obesity paradox" (i.e. the potential protective effect of overweight against mortality and the negative effect of underweight) [9].…”

Section: General Considerationsmentioning

confidence: 99%

Aging and nutrition. Paving the way to better health

Molina-Molina

Garruti

Shanmugam

et al. 2020

Romanian Journal of Internal Medicine

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AbstractSufficient caloric intake is important to maintain the balanced health status, especially during the period of aging, as aging and sickness share paths. Maintaining adequate nutritional balance is the best preventive measure to counteract the risk of malnutrition. There are several causes for malnutrition in elderly people, and some techniques such as anthropometric measurements, laboratory and clinical parameters could help to diagnose malnutrition in these patients. The use of a simple validated questionnaire called the ‘Mini Nutritional Assessment’ measures the nutritional status of elderly patients. In this review, we discuss about the malnutrition in elderly people with and without a known cause and we present some of nutritional intervention. There are promising strategies that help overcoming malnutrition.

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“…However, one should also consider the so-called "obesity paradox" (i.e. the potential protective effect of overweight against mortality and the negative effect of underweight) [9].…”

Section: General Considerationsmentioning

confidence: 99%

Aging and nutrition. Paving the way to better health

Molina-Molina

Garruti

Shanmugam

et al. 2020

Romanian Journal of Internal Medicine

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“…In general, studies have shown that the distribution of body fat, and not the mass of body fat, is the key to explaining the obesity paradox [6]. Knowledge of the changes in body composition and fat distribution may help to understand the cause of obesity [7].…”

Section: Introductionmentioning

confidence: 99%

Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox

Koyama

Kuriyama

Uehara

2020

IJERPH

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Background: The aim of this study was to investigate whether plasma midregional proadrenomedullin (MR-proADM) reflected body composition, such as body mass index (BMI), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), VAT/SAT ratio, body fat mass (BFM), and skeletal muscle mass (SMM). Methods: A total of 2244 individuals (727 men and 1517 women) were included in the study. Multiple regression analysis was performed to assess the combined influence of variables: age, daily alcohol consumption, Brinkman index, sleeping time, metabolic equivalents, anamnesis for hypertension, dyslipidemia, diabetes, and body composition of MR-proADM, by using a stepwise forward selection method. Results: MR-proADM was significantly related to all anthropometric indices (BMI, VAT, SAT, VAT/SAT ratio, BFM, and SMM) in men and women. On the basis of a stepwise forward selection method, VAT (men: beta = 0.184, p < 0.001, women: beta = 0.203, p < 0.001) and BFM (beta = 0.181, p < 0.001) in women, were found to be significantly associated with MR-proADM. Conclusion: This study suggests that plasma MR-proADM concentration is a more reliable indicator of VAT for fat distribution, and thus, MR-proADM may help better understand the obesity paradox. Changes in circulating levels of MR-proADM could possibly reflect changes in body composition, endocrine, and metabolic milieu.

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“…For example, a study in Germany showed that the prevalence of overweight in people aged 80 years and over was lower than that in younger adults [23]. By contrast, a systematic review of 72 papers (1999-2019) showed that the prevalence of obesity increases among those aged 69 years in both men and women and then tends to decrease [73]. Future research should use longitudinal datasets to examine the association of obesity risk during ageing more rigorously.…”

Section: Discussionmentioning

confidence: 99%

A Reversal of the Association between Education Level and Obesity Risk during Ageing: A Gender-Specific Longitudinal Study in South Korea

Chung

Kim

2020

IJERPH

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This study aimed to examine and quantify obesity risk across different education levels during ageing using the dataset of a nationally representative longitudinal survey. A total of 45,391 observations of 9991 individuals aged ≥45 years were included in this study. Obesity was defined as a body mass index of ≥25, according to a guideline for Asians by the World Health Organization, and education level was grouped into three categories. Socio-demographics, lifestyles, and health conditions were used as covariates. Adjusted odds ratios and predicted probabilities of obesity were computed and adjusted for a complex survey design. With respect to gender, education level and age were significantly associated with obesity risk, and the association was stronger in women than in men. Furthermore, education level was negatively associated with obesity risk in the middle age in each gender. However, the association became positive in the old age, specifically among highly educated women. Therefore, policy efforts to reduce obesity risk and the resulting education gradients should be established based on studies considering their old age. Further longitudinal studies are required to examine whether these findings are valid in other socio-cultural or economic settings.

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Obesity paradox and aging

Cited by 123 publications

References 64 publications

Aging and nutrition. Paving the way to better health

Aging and nutrition. Paving the way to better health

Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox

A Reversal of the Association between Education Level and Obesity Risk during Ageing: A Gender-Specific Longitudinal Study in South Korea

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