Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants

Hernández-Bautista, René; Mahmoud, Ayman M.; Königsberg, Mina; Guerrero, Norma E. López Díaz

doi:10.1016/j.biopha.2018.12.108

Cited by 96 publications

(71 citation statements)

References 215 publications

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“…After LSG, L-glutamate degradation pathway increased. L-glutamate is used to produce monosodium glutamate (MSG), a commonly used food additive that contributes to metabolic disorders [41] , [42] , [43] , [44] . Our results suggested that glutamate biosynthesis of gut microbiota might be an influencing factor of visceral fat accumulation.…”

Section: Discussionmentioning

confidence: 99%

A metagenome-wide association study of gut microbiome and visceral fat accumulation

Nie

Chen

et al. 2020

Computational and Structural Biotechnology Journal

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Section: Discussionmentioning

confidence: 99%

A metagenome-wide association study of gut microbiome and visceral fat accumulation

Nie

Chen

et al. 2020

Computational and Structural Biotechnology Journal

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“…Obesity is associated with many comorbidities that sometimes may lead to death. Metabolic complications include glucose intolerance and insulin resistance, metabolic syndrome, oxidative stress, and low grade inflammation [21]. Scientists are looking for an effective treatment to improve the patient's condition and prevent comorbidities.…”

Section: Discussionmentioning

confidence: 99%

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

Haliński

Pakiet

Jabłońska

et al. 2019

JCM

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Bariatric surgery leads to metabolic benefits in patients with obesity, but their mechanisms are not well understood. The appropriate composition of serum amino acids (AA) is important for sufficient supply of these components into various tissues and organs. Obesity leads to alterations in serum AA concentrations. The aim of this study was to examine the effect of one anastomosis gastric bypass (OAGB), a promising type of bariatric surgery, on serum AA concentrations, which were assayed by LC-MS in serum of 46 bariatric patients prior to and 6–9 months after OAGB, as well as in 30 lean control subjects. The results were analyzed by principle components analysis and metabolic pathway analysis. PCA analysis showed that OAGB led to normalization of serum AA concentrations of patients with obesity to a pattern similar to the control subjects, and the concentrations of essential AA remained decreased after OAGB. Changes of individual AA and their associated metabolic pathways were also presented. OAGB caused normalization of the AA profile, which may contribute to improvement of glucose homeostasis and reduction of cardiovascular risk. Considering decreased essential AA concentrations after OAGB, increased intake of high protein food should be recommended to the patients after this type of bariatric surgery.

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“…Flavonoids possess multiple health benefits, including antioxidant and free radical scavenging, anti-inflammatory, and cytoprotective [45–48]. Given the role of oxidative stress and inflammation in the pathogenesis of obesity, diabetes, and CVD [4, 49–53], the antioxidant potential of flavonoids may play a key role in their beneficial therapeutic effects. The chemical structure of flavonoids indicates that they act as radical scavengers, oxygen quenchers, and hydrogen-donating antioxidants.…”

Section: Biological Activities Of Citrus Flavonoidsmentioning

confidence: 99%

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Mahmoud

Hernández-Bautista

Sandhu

et al. 2019

Oxidative Medicine and Cellular Longevity

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The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes. Although citrus flavonoids exerted multiple beneficial effects, their mechanisms of action are not completely established. In this review, we summarized recent findings and advances in understanding the mechanisms underlying the protective effects of citrus flavonoids against oxidative stress, inflammation, diabetes, dyslipidemia, endothelial dysfunction, and atherosclerosis. Further studies and clinical trials to assess the efficacy and to explore the underlying mechanism(s) of action of citrus flavonoids are recommended.

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Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants

Cited by 96 publications

References 215 publications

A metagenome-wide association study of gut microbiome and visceral fat accumulation

A metagenome-wide association study of gut microbiome and visceral fat accumulation

One Anastomosis Gastric Bypass Reconstitutes the Appropriate Profile of Serum Amino Acids in Patients with Morbid Obesity

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

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