Obesity-related alterations in anticipatory postural mechanisms associated with gait initiation

Caderby, Teddy; Caron, Nathan; Verkindt, Chantal; Bonazzi, Bruno; Dalleau, Georges; Peyrot, Nicolas

doi:10.1007/s00221-020-05914-8

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…It is presently unclear whether this also applies to people with PD. Other work has shown that the effectiveness of an APA is not only determined by the APA amplitude but also COM velocity at toe-off plays an important role [ 35 ], which was not assessed in this study.…”

Section: Discussionmentioning

confidence: 99%

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Towards a better understanding of anticipatory postural adjustments in people with Parkinson’s disease

Seuthe,

Heinzel,

Hulzinga

et al. 2024

PLoS ONE

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Introduction Previous studies have shown that anticipatory postural adjustments (APAs) are altered in people with Parkinson’s disease but its meaning for locomotion is less understood. This study aims to investigate the association between APAs and gait initiation, gait and freezing of gait and how a dynamic postural control challenging training may induce changes in these features. Methods Gait initiation was quantified using wearable sensors and subsequent straight walking was assessed via marker-based motion capture. Additionally, turning and FOG-related outcomes were measured with wearable sensors. Assessments were conducted one week before (Pre), one week after (Post) and 4 weeks after (Follow-up) completion of a training intervention (split-belt treadmill training or regular treadmill training), under single task and dual task (DT) conditions. Statistical analysis included a linear mixed model for training effects and correlation analysis between APAs and the other outcomes for Pre and Post-Pre delta. Results 52 participants with Parkinson’s disease (22 freezers) were assessed. We found that APA size in the medio-lateral direction during DT was positively associated with gait speed (p<0.001) and stride length (p<0.001) under DT conditions at Pre. The training effect was largest for first step range of motion and was similar for both training modes. For the associations between changes after the training (pooled sample) medio-lateral APA size showed a significant positive correlation with first step range of motion (p = 0.033) only in the DT condition and for the non-freezers only. Conclusions The findings of this work revealed new insights into how APAs were not associated with first step characteristics and freezing and only baseline APAs during DT were related with DT gait characteristics. Training-induced changes in the size of APAs were related to training benefits in the first step ROM only in non-freezers. Based on the presented results increasing APA size through interventions might not be the ideal target for overall improvement of locomotion.

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Section: Discussionmentioning

confidence: 99%

“…effectiveness of an APA is not only determined by the APA amplitude but also COM velocity at toe-off plays an important role [35], which was not assessed in this study.…”

Section: Plos Onementioning

confidence: 94%

Towards a better understanding of anticipatory postural adjustments in people with Parkinson’s disease

Seuthe,

Heinzel,

Hulzinga

et al. 2024

PLoS ONE

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“…The changes in the kinematics of the linear gait parameters may negatively influence energy expenditure and exercise tolerance among individuals with obesity [ 6 ]. Studies in the broader literature have described the changes that affect obese individuals, ranging from changes in balance to a lack of performance [ 7 , 8 , 9 ]. Thus, individuals with a high body fat percentage are prone to fatigue.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gait Alteration on Fatigability during Walking in Adult Women with High Body Fat Composition

Aldhahi

2022

Medicina

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Background and Objective: The risk factors for injury due to alterations in gait efficiency and fatigability during walking are a rising concern. Therefore, the aims of this study were to characterize the changes in gait pattern and performance fatigability among adult women with a high body fat percentage and to study the association between the gait pattern and performance fatigability during walking. Materials and Methods: A total of 160 adult women were enrolled in the study and were divided into two groups: a high-body-fat percentage group (HBF; n = 80; fat% = 42.49 ± 3.51) and a comparison group with a normal body fat percentage (NBF; n = 80; fat% = 29.68 ± 4.30). The 10 min walking test (10-MWT) was used to measure performance fatigability. Treadmill-based gait analysis was used for the acquisition of gait parameters. The correlation between the variables was examined using Pearson’s correlation coefficient. Forward stepwise linear regression was carried out to examine the association between all independent variables, and performance fatigability was adjusted for age and height. The level of statistical significant was set at p-value < 0.05 in all analyses. Results: The mean performance fatigability during the 10-MWT was reported to be high (1.4 ± 0.13) among the participants with HBF, as compared with a fatigability of 1.25 ± 0.11 in the NBF group. The data analysis of the spatial parameters indicated that stride length and step length were statistically smaller in the participants with HBF, as compared with the NBF group. The effects of average maximum force, speed, cadence, step length, and stride length explained the variation in the performance fatigability by 61% (p = 0.007). Conclusion: The findings of this study showed that gait alteration due to excess body fat induced a reduction in performance, as reflected by the high fatigability performance during walking. The study demonstrated a significant association between the severity of performance fatigability and spatial gait parameters.

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A clinical application of gait quality patterns in osteoarthritis

Castro Mejia,

Gulde,

González Salinas

2024

Gait & Posture

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Obesity-related alterations in anticipatory postural mechanisms associated with gait initiation

Cited by 7 publications

References 57 publications

Towards a better understanding of anticipatory postural adjustments in people with Parkinson’s disease

Towards a better understanding of anticipatory postural adjustments in people with Parkinson’s disease

Effect of Gait Alteration on Fatigability during Walking in Adult Women with High Body Fat Composition

A clinical application of gait quality patterns in osteoarthritis

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