Obesity-related systemic oxidative stress: An important factor of poor asthma control

To, Masako; Kono, Yuta; Ogura, Naoto; Mikami, Shintaro; Honda, Natsuki; Hitani, Akihiro; Kano, Ichino; Haruki, Kosuke; To, Yasuo

doi:10.1016/j.alit.2017.06.002

Cited by 19 publications

(15 citation statements)

References 10 publications

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“…5 could also promote ROS production in human lung alveolar epithelial A549 cells (Deng et al, 2013). ROS production is closely associated with neutrophilic and Th17 inflammation, which are involved in the development of asthma (Chesné et al, 2014;Ray and Kolls, 2017;Carr et al, 2018), and correlated to exacerbation and asthmatic patients with obesity (Suzuki et al, 2008;Kim et al, 2014;Ray and Kolls, 2017;To et al, 2018). Elevated ROS generation from neutrophils and macrophages in asthmatic subjects is correlated to increase of NLRP3 inflammation (Simpson et al, 2014), leading to airway hyperresponsiveness, and lung fibrosis (Kim et al, 2014;Sun et al, 2015).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Besides, calorie restriction can also ameliorate the circulating insulin growth factor 1 (IGF-1) level and mTOR activation, which could lead to premature senescence in cells (Fontana et al, 2018). Asthma coexistence with obesity tends to become more severe and difficult-totreat (Kim et al, 2014;To et al, 2018). To et al (2018) demonstrated that obesity-derived oxidative stress was to blame for the asthma outcomes.…”

Section: Caloric Restriction and Weight Lossmentioning

confidence: 99%

“…Asthma coexistence with obesity tends to become more severe and difficult-totreat (Kim et al, 2014;To et al, 2018). To et al (2018) demonstrated that obesity-derived oxidative stress was to blame for the asthma outcomes. Obesity is more associated with Th17 and neutrophilic inflammatory phenotypes, leading to NLRP3 inflammasome activation (Kim et al, 2014), which would induce cellular senescence and SASP (Davalli et al, 2016).…”

Section: Caloric Restriction and Weight Lossmentioning

confidence: 99%

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Potential Role of Cellular Senescence in Asthma

Wang

Yang

et al. 2020

Front. Cell Dev. Biol.

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Cellular senescence is a complicated process featured by irreversible cell cycle arrest and senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent cells, and low-grade inflammation. Cellular senescence not only occurs during the natural aging of normal cells, but also can be accelerated by various pathological factors. Cumulative studies have shown the role of cellular senescence in the pathogenesis of chronic lung diseases including chronic obstructive pulmonary diseases (COPD) and idiopathic pulmonary fibrosis (IPF) by promoting airway inflammation and airway remodeling. Recently, great interest has been raised in the involvement of cellular senescence in asthma. Limited but valuable data has indicated accelerating cellular senescence in asthma. This review will compile current findings regarding the underlying relationship between cellular senescence and asthma, mainly through discussing the potential mechanisms of cellular senescence in asthma, the impact of senescent cells on the pathobiology of asthma, and the efficiency and feasibility of using anti-aging therapies in asthmatic patients.

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Section: Oxidative Stressmentioning

confidence: 99%

Section: Caloric Restriction and Weight Lossmentioning

confidence: 99%

Section: Caloric Restriction and Weight Lossmentioning

confidence: 99%

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Potential Role of Cellular Senescence in Asthma

Wang

Yang

et al. 2020

Front. Cell Dev. Biol.

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“…Both eosinophils and neutrophils participate in the innate immune response and produce ROS and RNS in response to different stimuli [ 6 ]. There is strong evidence supporting a significant role for oxidative stress in asthma disease and development [ 17 , 34 , 43 , 44 ], ( Figure 2 ) which is further increased during asthma exacerbations and in obese subjects [ 45 , 46 ], two conditions that are also associated with increased airway neutrophilia [ 47 , 48 ].…”

Section: Oxidative Stress and Asthmamentioning

confidence: 99%

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

Bullone

Lavoie

2017

IJMS

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Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure and function that could contribute to asthma occurrence, and/or clinical presentation in the elderly. Also, naturally occurring equine asthma will be discussed as a possible model for studying the importance of oxidative stress and immun-aging/inflamm-aging in humans.

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“…Hyperleptinemia, tissue dysfunction, low antioxidant defenses, chronic inflammation, and the generation of postprandial ROS are factors involved in the development of obesity in which oxidative stress participates [75] (Figure 5). As the increase in oxidative stress in accumulated fat is, at least in part, the underlying cause of adipocytokine dysregulation and the development of the metabolic syndrome [76], it is known that obesity induces oxidative stress through various mechanisms such as chronic inflammation, endothelial dysfunction, and mitochondrial dysfunction [77].…”

Section: Oxidative Stress and Obesitymentioning

confidence: 99%

Adipose Tissue and Inflammation

Muñoz‐Carrillo¹,

Campo²,

Coronado³

et al. 2018

Adipose Tissue

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Adipose tissue is composed mainly by adipocytes and stromal-vascular fraction, which are composed by different cell types including macrophages. There are three types of adipose tissue: brown (BrAT), white (WAT), and beige (BeAT). BrAT is less abundant and is implicated in lipid oxidation and energy balance; BeAT has the pathway of adaptive thermogenesis, and WAT is endocrine in nature and lipid storage site and is implicated as an endocrine organ that secretes hormones and different molecules. These molecules are pro-inflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, leptin, adiponectin, and others, are involved with the development of adipose tissue inflammation and obesity. This pathological condition, together with other factors such as oxidative stress, may develop insulin resistance and the pathogenesis of type 2 diabetes mellitus (T2DM).

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Obesity-related systemic oxidative stress: An important factor of poor asthma control

Cited by 19 publications

References 10 publications

Potential Role of Cellular Senescence in Asthma

Potential Role of Cellular Senescence in Asthma

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

Adipose Tissue and Inflammation

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