Background and Objectives: The gap in noise auditory brainstem responses (GIN-ABR) is a valuable assessment tool for auditory temporal processing, offering non-invasive and objective measurements encompassing the entire auditory system from the cochlea to the brainstem. This method has been utilized in investigating various factors, including age-related effects, hearing loss, and tinnitus. This systematic review was conducted to present a thorough examination of (GIN-ABR), encompassing its methodology, applications, and inherent limitations. Methods: This study was conducted based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Cochrane, PubMed, and Ovid databases were used to extract English articles from 1990 to June 2023. The search terms used were “gap in noise auditory brainstem response”, “ABR gap detection”, “ABR gap duration”, “ABR gap threshold”, and “ABR temporal processing”. Articles were included if gap-evoked ABR was used, investigating the effect of any factor on the responses, and using any gapped stimulus type. Articles whose evoked potentials did not include ABR waves were excluded. The outcome of interest was gap-evoked ABR in different participant groups. Results: A total of 10 studies were deemed suitable for inclusion in the review. The articles were reviewed that including the study population, the methods, and the results. Despite the variability in the results of the studies, in the aged group, longer latency shifts and decreased peak amplitude were reported compared to the young group. Correspondence of behavioral thresholds with GIN-ABR has also been mentioned in studies. Conclusion: The GIN-ABR method has been extensively utilized in investigating various factors, including age-related effects, hearing loss, and tinnitus. Notably, GIN-ABR has several clinical advantages, such as cost-effectiveness, shorter test duration, independence from alertness levels, attention, sleep depth fluctuations, or medication. Additionally, it has shown its compatibility with psychophysical tests. Further research is warranted to explore the impact of various factors on different components of GIN-ABR. Consequently, with its promising findings and growing body of research, the gap in noise test has the potential to be gradually integrated into the set of audiological clinical evaluations.