Objective monitoring of nasal airway inflammation in rhinitis

Howarth, Peter H.; Persson, C. G. A.; Meltzer, Eli O.; Jacobson, Mikila R.; Durham, Stephen R.; Silkoff, Philip E.

doi:10.1016/j.jaci.2004.12.1134

Cited by 127 publications

(162 citation statements)

References 188 publications

(251 reference statements)

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“…Nasal biopsy studies have shown the phenotype of nasal tissue in allergic rhinitis (96,97). However, less is known about biopsies in NAR (11,26,98,99) although histological findings in NAR show a strong interaction between infiltrating mononuclear cells and the mucosal epithelium (100).…”

Section: Mechanisms: Inflammatory Mechanismsmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

170

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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Section: Mechanisms: Inflammatory Mechanismsmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

170

148

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that smoking decreased nasal NO levels. [14,15] Low levels of NO were also detected in patients with severe nasal obstruction and inflammation. [16][17][18] The association of asthma with AR is well known, and it is also well known that AR is a risk factor for asthma.…”

Section: Discussionmentioning

confidence: 99%

“…[13] Each patient remained in a sitting position, extended their neck gently backward to 30°from the horizontal, such that the nasal cavity was pointing upward, and instilled fluid would not be lost anteriorly because of gravity. [14] The posterior loss was limited by having subjects close their soft palate, hold their breath during the…”

Section: Outcome Parametersmentioning

confidence: 99%

“…The volume instilled within each nostril was 5.0 mL, and the fluid was left within the nasal cavity for 10 seconds. [14] The subject then leaned forward and expelled the fluid from the nostrils by gently exhaling into a container that had been washed with clean, distilled water. Fluid collected from both nasal cavities was transferred into a plastic tube resistant to -70°C and sent to a biochemistry research laboratory swiftly.…”

Section: Ent Updatesmentioning

confidence: 99%

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Nasal nitric oxide and its metabolites as potential biomarkers for the diagnosis and follow-up of allergic rhinitis

Çoşkun¹,

Arslan²,

İmamoğlu³

2017

ENT Updates

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“…Unfortunately, there are few effective treatments for episodic viral wheeze. Recent studies have demonstrated that, in contrast to asthma, oral steroid treatment is ineffective for acute episodes of episodic viral wheeze (10). Preventative treatment with montelukast gives modest protection against wheezing episodes (11), and inhaled steroids offer none (12).…”

Section: Birth Cohorts In Childhood Asthma: Lessons and Limitationsmentioning

confidence: 99%

The Pros and Cons of Airway Lining Fluid Composition Analysis

Johansson¹

2012

Am J Respir Crit Care Med

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Objective monitoring of nasal airway inflammation in rhinitis

Cited by 127 publications

References 188 publications

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Nasal nitric oxide and its metabolites as potential biomarkers for the diagnosis and follow-up of allergic rhinitis

The Pros and Cons of Airway Lining Fluid Composition Analysis

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Objective monitoring of nasal airway inflammation in rhinitis

Cited by 127 publications

References 188 publications

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Nasal nitric oxide and its metabolites as potential biomarkers for the diagnosis and follow-up of allergic rhinitis

The Pros and Cons of Airway Lining Fluid Composition Analysis

Contact Info

Product

Resources

About

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper