Observance of Kassowitz law-late congenital syphilis: Palatal perforation and saddle nose deformity as presenting features

Abstract

Late congenital syphilis refers to the people with syphilis from the age of 2 to 30 years. We report a case of late congenital syphilis in a 9 year old girl with perforation of palate and saddle nose deformity. Kassowitz law was also observed (if a woman with untreated syphilis has series of pregnancies, the likelihood of infection of the fetus in later pregnancies becomes less). Venereal Disease Research Laboratory (VDRL) and Treponema pallidum hemagglutination (TPHA) were reactive. Computed tomography (CT) scan of paranasal sinus showed maxillary and nasal polyps. The case reported here is a rare presentation of late congenital syphilis with perforation of palate and saddle nose deformity.

Infections at the maternal–fetal interface: an overview of pathogenesis and defence

“…Congenital transmission occurs less frequently with subsequent pregnancies, an observation known as Kassowitz’s law. This observation suggests that the maternal immune response to T. pallidum can limit the frequency of congenital syphilis, but the vertical transmission risk is never eliminated 87 – 90 . This has also been shown in a guinea pig model of congenital syphilis, which is the best-described model for this phenomenon 90 .…”

Ausgewählte seltene rhinologische Krankheitsbilder Pathogenese – Klinik – Therapie

“…Die Diagnostik besteht in der klinischen, histopathologischen, mikroskopischen und serologischen Analyse. Die antibiotische Therapie erfolgt mit Penicillinen, bei Penicillinallergie mit Cephalosporinen, Makroliden oder Tetrazyklinen über Wochen [39][40][41][42][43][44][45][46][47][48]. Pseudomonas aeruginosa nachgewiesen, wobei in 25-44 % der Patienten mit sinunasalen Beschwerden eine multimikrobielle Infektion auftritt.…”

Orphan diseases of the nose and paranasal sinuses: Pathogenesis – clinic – therapy

“…Antibiotic therapy is applied with penicillin, and in cases of penicillin intolerance, cephalosporins, macrolides, or tetracyclines are administered for several weeks [ 29 ], [ 30 ], [ 31 ], [ 32 ], [ 33 ], [ 34 ], [ 35 ], [ 36 ], [ 37 ], [ 38 ].…”