2019
DOI: 10.3892/ol.2019.9966
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Observation of clinical efficacy and toxic and side effects of pirarubicin combined with cytarabine on acute myeloid leukemia

Abstract: Efficacy and toxic and side effects of pirarubicin combined with cytarabine and mitoxantrone combined with cytarabine on the treatment of initially treated acute myeloid leukemia (AML) were compared. A retrospective analysis was performed on the medical records of 76 AML patients who were initially treated in Weifang People's Hospital. Among them, 36 patients (observation group) were treated with pirarubicin combined with cytarabine, and 40 patients (control group) were treated with mitoxantrone combined with … Show more

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Cited by 4 publications
(4 citation statements)
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References 28 publications
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“…[15] Chemotherapy has similar side effects and drug resistance possibilities. [16] Hematopoietic stem cell transplantation is one of the most used methods in the treatment of leukemia. There are significant risks in terms of recipient and donor for this treatment.…”
Section: Discussionmentioning
confidence: 99%
“…[15] Chemotherapy has similar side effects and drug resistance possibilities. [16] Hematopoietic stem cell transplantation is one of the most used methods in the treatment of leukemia. There are significant risks in terms of recipient and donor for this treatment.…”
Section: Discussionmentioning
confidence: 99%
“…The side effects of high doses of radiotherapy against our normal cells are prominent ( Shimada et al, 2014 ). Chemotherapy may have similar side effects and the possibility of drug resistance ( Lv et al, 2019 ). Hematopoietic stem cell transplants are one of the most frequently used methods in the treatment of leukemia.…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, purine analogs, 6-mercaptopurine and 6-thioguanine, obstruct the synthesis of purine 53 . Gemcitabine and cytarabine are nucleoside analogs competitively incorporated into replicating DNA internucleoside, thus inhibiting nucleotide chain elongation; they have been used extensively in treating leukemia 55, 56 . Recently, efforts have been made to target the metabolic enzymes or proteins that are differentially expressed in cancer.…”
Section: Targeting Metabolismmentioning
confidence: 99%