Observation of Cyclosporin A: Sustained Release Intraocular Lens Implantation in Rabbit Eyes

Teng, Hui; Sun, Jing; Wen, Ke; Han, Guoge; Tian, Fang

doi:10.1080/02713683.2022.2110598

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…This review aims to summarize the effectiveness and safety of CsA delivery platforms in veterinary ophthalmology. However, it is important to highlight numerous studies and great progress in human ophthalmology such as the intracameral drug-delivery system for high-risk penetrating keratoplasty [ 6 , 7 ], modified intraocular lens to inhibit post-cataract surgery uveitis and preventing posterior capsular opacification [ 8 , 9 , 10 , 11 ], silica-thermogel nanohybrids sustainably releasing drugs after subconjunctival injection [ 12 , 13 ], or a glaucoma drainage device containing CsA and poly(lactic-co-glycolic acid) (PLGA) to prevent postoperative fibrosis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology

et al. 2022

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Cyclosporine A (CsA) is a selective and reversible immunosuppressant agent that is widely used as a medication for a wide spectrum of diseases in humans such as graft versus host disease, non-infectious uveitis, rheumatoid arthritis, psoriasis, and atopic dermatitis. Furthermore, the CsA is used to treat keratoconjunctivitis sicca, chronic superficial keratitis, immune-mediated keratitis and equine recurrent uveitis in animals. The selective activity of Cyclosporine A (CsA) was demonstrated to be an immunomodulation characteristic of T-lymphocyte proliferation and inhibits cytokine gene expression. Moreover, the lipophilic characteristics with poor bioavailability and low solubility in water, besides the side effects, force the need to develop new formulations and devices that will provide adequate penetration into the anterior and posterior segments of the eye. This review aims to summarize the effectiveness and safety of cyclosporine A delivery platforms in veterinary ophthalmology.

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Section: Introductionmentioning

confidence: 99%

Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology

et al. 2022

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Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Rykowska,

Michałkiewicz,

Nowak

et al. 2024

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The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.

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Observation of Cyclosporin A: Sustained Release Intraocular Lens Implantation in Rabbit Eyes

Cited by 2 publications

References 29 publications

Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology

Cyclosporine A Delivery Platform for Veterinary Ophthalmology—A New Concept for Advanced Ophthalmology

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

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