We show that an inhomogeneous defocusing nonlinearity that grows toward the periphery in the positive and negative transverse directions at different rates can support strongly asymmetric fundamental and multipole bright solitons, which are stable in wide parameter regions. In the limiting case when nonlinearity is uniform in one direction, solitons transform into stable domain walls (fronts), with constant or oscillating intensity in the homogeneous region, attached to a tail rapidly decaying in the direction of growing nonlinearity.OCIS Codes: 190.4360, 190.6135 Interest in the evolution of light beams in materials with spatially inhomogeneous parameters, such as refractive index or nonlinearity, is motivated by the possibility to control diffraction broadening for beam shaping and steering. For example, the strength and sign of the effective diffraction can be managed in periodic refractive-index landscapes, with the aim to create nonlinear modes and propagation regimes that are not possible in uniform media [1][2][3]. Modulation of the local strength of the nonlinearity can be also used to control the beam dynamics via effective pseudo-potentials whose impact on light propagation crucially depends on its intensity. Various types of solitons were predicted in nonlinear pseudo-potentials [4], including onedimensional solitons in nonlinear [5][6][7][8][9] and combined linear-nonlinear [10-12] lattices, exact modes supported by specially designed localized focusing nonlinearities [13], two-dimensional solitons supported by localized or periodic nonlinearities [14][15][16][17]. Formation of bright solitons in pseudo-potentials requires the presence of domains with focusing nonlinearity, assuming that the nonlinearity modulation depth is limited. However, it was recently shown that purely defocusing nonlinearities also support bright solitons with a finite total power, provided that the nonlinearity strength grows toward the periphery of the medium faster than D r , where D is the spatial dimension [18][19][20][21]. An unusual property of such solitons is that their symmetry and asymptotic form are determined by the nonlinearity profile, and do not depend on the propagation constant. Thus far, only symmetric solitons were predicted in settings of this type, while neither strongly asymmetric modes nor their limit form representing domain walls (DWs), which separate filled and empty domains, have been discovered. Such DWs have been studied only in materials with linear-refractiveindex landscapes [22][23][24][25].In this Letter we show that asymmetric defocusing nonlinearities characterized by different rates of the nonlinearity growth in the positive and negative transverse directions, can give rise to asymmetric bright solitons that may be stable. They turn into stable DWs if the nonlinearity becomes uniform in one direction.